个人简历

石磊，中国医学科学院基础医学研究所、北京协和医学院 “协和学者”特聘教授，博士生导师。2001年毕业于武汉大学生命科学学院，获学士学位，2006年毕业于中国协和医科大学基础医学研究所生化及分子生物学专业，获博士学位。2007-2012年在耶鲁大学、纽约大学进行博士后研究，2014回国加入基础所工作，获国自然基金委“优青”基金、面上基金支持，并获2015年度“求是杰出青年学者奖”。担任中国生物物理学会生物膜生物学专业分会理事。近年来一直从事膜蛋白的功能与机制、囊膜病毒感染复制的相关研究。

研究领域

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近期论文

1. Zika NS1–induced ER remodeling is essential for viral replication. Yali Ci, ZhongYu Liu, NaNa Zhang, Yuqiang Niu, Yang Yang, Caimin Xu, Wei Yang#, ChengFeng Qin#, and Lei Shi#. J. Cell Biol. 2020, 219 (2): e201903062.\r
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2. Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase. Shan Xu, Yali Ci, Leijie Wang, Yang Yang, Leiliang Zhang , Caimin Xu Chengfeng Qin and Lei Shi#. Nucleic Acids Research. 2019, Vol. 47, No. 16 8693–8707.\r
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3. Zika NS2B is a crucial factor recruiting NS3 to the ER and activating its protease activity. Huaipeng Xing, Shan Xu, Fangfei Jia, Yang Yang, Caimin Xu, Chengfeng Qin#，Lei Shi#. Virus Research. 275 (2020) 197793.\r
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4. Vesicular stomatitis virus G protein transmembrane region is crucial for the hemi-fusion to full fusion transition. Yali Ci, Yang Yang, Caimin Xu, Lei Shi#. Sci Rep. 2018 Jul 13;8(1):10669.\r
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5. ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells. Ci Y, Shi K, An J, Yang Y, Hui K, Wu P, Shi L#, Xu C#. Cell Death Dis. 2014 Nov 27;5:e1542.\r
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6. Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo. Yang Y, Luo H, Hui K, Ci Y, Shi K, Chen G, Shi L#, Xu CM#.\r
Oncol Rep. 2015 Dec 10. doi: 10.3892/or.2015.4484.\r
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7. SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open. Shi L, Shen QT, Alexander Kiel, Wang J, Wang HW, Melia TJ, Rothman JE, Frédéric Pincet. Science. 2012 Mar 16, 355:1355-1359. (由美国《科学家》杂志（The Scientist）报道，并被Faculty 1000推荐)\r
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8. Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores. Shi L*, Kevin Howan*, Qing-tao Shen, Yong Jian Wang, James E. Rothman, Frédéric Pincet.\r
Nature Protocols. 2013 May;8(5):935-48. ( * these authors contribute equally).\r
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9. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Shi L, Kümmel D, Coleman J, Melia TJ, Giraudo CG. \r
Mol Biol Cell. 2011 Nov;22(21):4150-60.\r
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10. Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons. Li W*, Shi L*, You Y, Gong Y, Yin B, Yuan J, Peng X.\r
BMC Biol. 2010 Jun 18;8:86. ( * these authors contribute equally).\r
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11. Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation. Shi L, Yue J, You Y, Yin B, Gong Y, Xu C, Qiang B, Yuan J, Liu Y, Peng X.\r
Cell Signal. 2006 Nov;18(11):1995-2003.