个人简历

宋伟，理学博士，研究员、博士生导师。课题组研究方向：雄性生殖及相关重大疾病（男性不育与肿瘤）的分子机理与转化应用研究。主要应用现代分子生物学与细胞生物学方法，从分子到整体动物水平研究在精子发生的关键过程中表达的编码/长非编码基因的功能，并开展雄性生精障碍的基因治疗研究，为精子发生障碍所导致的不育症诊治和预防提供理论与应用基础。同时，开展“从雄性生殖角度探寻恶性肿瘤原始起源”的研究工作，发现新的肿瘤特异性基因并开展机制与转化研究，为恶性肿瘤的诊断与治疗提供全新靶标与候选药物。

研究领域

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近期论文

1. Kai Li, Jiayue Xu, Yanyun Luo, et al. Panoramic transcriptome analysis and functional screening of long non-coding RNAs in mouse spermatogenesis. Genome Research, 2020, 31(1)：13-26.\r
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2. Shangze Li, Qipeng Shu, Yang Song, et al. Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nature Communications, 2019, 10: 3233.\r
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3. Fang Wang, Wei Song, Hongmei Zhao, et al. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research, 2017, 27(3): 416-439.\r
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4. Wei Song, Wenjie Liu, Hong Zhao, et al. Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signaling pathway. Nature Communications, 2015, 6: 8022.\r
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5. Xiaojuan Wang; Fan Wu; Han Wang; et al. PDCD6 Cooperates with C-Raf to Facilitate Colorectal Cancer Progression via Raf/MEK/ERK Activation. J Exp Clin Cancer Res.2020, 39: 147.\r
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6. Yuechao Zhao, Yiran Li, Jie Sheng, et al. P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs. J Exp Clin Cancer Res, 2019, 38(1): 379. \r
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7. Kai Li, Shunshun Zhong, Yanyun Luo, et al. A long noncoding RNA binding to QKI-5 regulates germ cell apoptosis via p38 MAPK signaling pathway. Cell Death Dis, 2019, 10:699.\r
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8. Xin Zhang, Yuechao Zhao, Changjun Wang, et al. Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels. Cell Communication and Signaling, 2018, 16: 65.\r
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9. Mengmeng Zhang, Fei Miao, Rong Huang, et al. RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1. J Exp Clin Cancer Res, 2018, 37:22.\r
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10. Longchang Xu, Yanlan Lu, Deqiang Han, et al. Rnf138 deficiency promotes apoptosis of spermatogonia in juvenile male mice. Cell Death Dis, 2017, 18; 8(5): e2795.\r
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申请专利：\r
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1. 源自RHBDD1的蛋白及其在制备用于检测结直肠癌或乳腺癌的单克隆抗体中的用途\r
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（201110310766.6）（已授权）\r
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2. 抗ACTL7a和GAPDH-2抗体的检测方法、试剂盒极其用途（201510164713.6）\r
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（已授权）\r
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3. 一种重组人白血病抑制因子的制备方法（201610642110.7）（已授权）\r
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4. 一种抗RNF138单克隆抗体的制备方法及其应用（202010452272.0）（已授权）\r
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5. 检测RHBDD1蛋白的ELISA方法及试剂盒（201610979636.4）\r
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6. 一种以RHBDD1 为靶点的抗肿瘤药物筛选模型及其方法（201811234898.3）\r
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7．RNF138作为预测结直肠癌对SC75741治疗敏感性的生物标志物的应用（2020112672310.0）