个人简历

李隽，籍贯河北，本科毕业于北京大学医学部基础医学专业，2010年在美国Texas A&M University 获得生物化学与生物物理博士学位。2010-2018年师从于哈佛医学院遗传系David Sinclair教授进行博士后研究。2018年8月至今，受聘于中国医学科学院基础医学研究所/北京协和医学院基础医学院，目前担任生物化学与分子生物学系课题组长，研究员。2018年入选中国医学科学院/北京协和医学院 “高端科技人才”引进专项支持计划“优秀青年人才”。\r
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本课题组主要从事衰老的分子机制和抗衰老干预方法的研究和应用。具体研究方向包括：\r
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（1）NAD代谢对衰老进程的调控\r
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（2）细胞衰老的发生机制及调控\r
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（3）DNA损伤/修复对细胞及机体水平衰老的影响和调控

研究领域

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近期论文

1. Evandro F. Fang, Chenglong Xie, Joseph A. Schenkel, Chenkai Wu, Qian Long, Honghua Cui, Yahyah Aman, Johannes Frank, Jing Liao, Huachun Zou, Ninie Y. Wang, Jing Wu, Xiaoting Liu, Tao Li, Yuan Fang, Zhangming Niu, Guang Yang, Jiangshui Hong, Qian Wang, Guobing Chen, Jun Li, Hou-Zao Chen, Lin Kang, Huanxing Su, Brian C. Gilmour, Xinqiang Zhu, Hong Jiang, Na He, Jun Tao, Sean Xiao Leng, Tanjun Tong, Jean Woo. A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks, Ageing Research Reviews, 2020;101174,\r
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2. Bolderson E, Burgess JT, Li J, et al. Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage. Nature Communication. 2019;10(1):5501.\r
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3. Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J.Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn and David A. Sinclair. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science, 2017, 355(6331): 1312-1317.\r
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4. Evandro Fei Fang, Henok Kassahun, Deborah L. Croteau, Morten Scheibye-Knudsen, Huiming Lu, Raghavendra A. Shamanna, Sumana Kalyanasundaram, Ravi Chand Bollineni, Mark A. Wilson, Wendy B. Iser, Bradley N. Wollman, Marya Morevati, Jun Li, Jesse S. Kerr, Qiping Lu, Tyler B. Waltz, Jane Tian, David A. Sinclair, Mark P. Mattson, Hilde Nilsen, Vilhelm A. Bohr. NAD+ replenishment significantly improves outcomes in Ataxia telangiectasia models via mitophagy and DNA repair, Cell Metabolism, 2016, 24(4): 566-581.\r
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5. Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism, Cell cycle. 2013,12(14): 2233-2240.\r
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6. Hubbard, P., Gomes, A., Dai, H., Li, J., Case, A., Considine, T., Riera, T., Lee, J., Yen, ES, Lamming, D., Pentelute, B., Schuman, E., Stevens, L., Ling, A., Armour, S., Michan, S., Zhao, H., Jiang, Y., Sweitzer, S., Blum, C., Disch, J., Ng, PY., Howitz, K., Hamaro, Y., Moss, J., Perni, R., Ellis, J., Vlasuk, G. and Sinclair, D.A. Evidence for a common mechanism of Sirt1 activation by small molecules. Science, 2013, 339(6124): 1216-1219.\r
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7. Jun Li and Paul Fitzpatrick. Regulation of Phenylalanine Hydroxylase: Conformational changes upon phosphorylation detected by H/D exchange and mass spectrometry, Arch Biochem Biophys. 2013, 535(2): 115-119.\r
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8. Jun Li, Udayar Ilangovan, Susan Daubner, Andy Hinck, Paul Fitzpatrick. Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase. Arch Biochem Biophys. 2011, 505(2): 250-255.\r
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9. Jun Li, Larry Dangott, and Paul Fitzpatrick. Regulation of Phenylalanine Hydroxylase: Conformational changes upon phenylalanine binding detected by H/D exchange and mass spectrometry. Biochemistry. 2010, 49(15): 3327-3335.\r
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10. Jun Li and Paul Fitzpatrick. Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad. Arch Biochem Biophys. 2008, 475: 164-168.\r
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11. Shu-yan Li, Zeng-Gang Li, Jun Li, Ju-hua Ni, and Hong Ti Jia. Expression and Editing Status of Glutamate Receptor GluR2 Subunit in Audiogenic Seizure-Susceptible P77PMC Rats. Chinese Journal of Biochemistry and Molecular Biology. 2005, 21 (1): 78-83.\r
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