个人简历

EDUCATIONr
Ph.D. in Chemistry New York University, New York, NY August 2001 Advisor: Nadrian C. Seemanr
B.S. in Chemistry Shandong University, Jinan, P.R.China July 1993r
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EMPLOYMENT AND APPOINTMENTr
09/2013 to Present Director, Center for Molecular Design and Biomimetics Biodesign Institute, Arizona State University, Tempe, AZr
09/2015 to Present Milton D. Glick Distinguished Professor School of Molecular Sciences & Biodesign Institute, Arizona State University, Tempe, AZr
01/2012 to 08/2015 Milton D. Glick Distinguished Professor Department of Chemistry and Biochemistry & Biodesign Institute,Arizona State University, Tempe, AZr
08/2008 to 01/2012 Professor Department of Chemistry and Biochemistry & Biodesign Institute,Arizona State University, Tempe, AZr
08/2004 to 08/2008 Assistant Professor Department of Chemistry and Biochemistry & Biodesign Institute,Arizona State University, Tempe, AZr
09/2001 to 07/2004 Assistant Research Professor Department of Computer Science, Duke University, Durum, NCr
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ENTREPRENEURSHIPr
02/2021 to Present Co-founder, Exodigm Biosciences, Inc.

研究领域

"""The theme of our research is to use nature's design rules as inspiration to advance biomedical, energy-related, and other technological innovations through the use of self-assembling molecules and materials. We aim to create intelligent materials with better component controls at the molecular level. Our interdisciplinary team is interested in designing bio-inspired molecular building blocks and programming their higher order assembly into systems that will perform complex functions. Our ultimate goals are 1) to engineer an information guided self-assembling molecular system for the finest possible interactions of molecules in a three-dimensional space; and 2) to create man-made molecular machines/molecular robotics through molecular design, molecular programming, directed molecular evolution and molecular systems engineering."""

近期论文

D. Fu', R. Pradeep', A. Prasad', F. Zhang, D. Williams, J. Schreck, H. Yan* and J. Reif*. Automated design of 3D DNA origami with non-rasterized 2D curvature, Science Advances 8, eade445, (2022).r
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X. Zhou', D. Satyabola', H. Liu, S. Jiang, X. Qi, L. Yu, S. Lin, Y. Liu, N.W. Woodbury*, H. Yan*. Two-Dimensional Excitonic Networks Directed by DNA Templates as an Efficient Model Light-Harvesting and Energy Transfer System, Angew. Chem. Int. Ed. 61, e2022112, (2022).r
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R. Pradeep', J. Procyk', P. Nandi, A. Prasad, Y. Xu, E. Poppleton, D. Williams, F. Zhang, H. Yan, P. Chiu*, N. Stephanopoulos*, and P. Sulc*, Coarse-Grained Simulations for the Characterization and Optimization of Hybrid Protein-DNA Nanostructures, ACS Nano 16, 14086�14096, (2022).r
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L. Ma, Y. Liu, C. Han, A. Movsesyan, P. Li, H. Li, P. Tang, Y. Yuan, S. Jiang, W. Ni, H. Yan, A. Govorov, Z. Wang, X. Lan*, DNA-Assembled Chiral Satellite-Core Nanoparticle Superstructures: Two-State Chiral Interactions from Dynamic and Static Conformations, Nano Letters 22, 4784−4791, (2022).r
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K. Chen, F. Xu, Y. Hu, H. Yan*, L. Pan*, DNA Kirigami Driven by Polymerase-Triggered Strand Displacemen, Small 18, 2201478, (2022).r
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X. Zhou, H. Liu, F. Djutanta, D. Satyabola, S. Jiang, X. Qi, L. Yu, S. Lin, R.F. Hariadi, Y. Liu, N.W. Woodbury*, H. Yan*, DNA-Templated Programmable Excitonic Wires for Micron-Scale Exciton Transport, Chem. 8, 2442-2459, (2022).r
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X. Zhou, S. Lin, H. Yan*, Interfacing DNA nanotechnology and biomimetic photonic complex: advances and prospects in energy and biomedicine, J. Nanobiotechnology 20, 257, (2022).r
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C. Simmons', T. MacCulloch', M. Krepl, M. Matthies, A. Buchberger, I. Crawford, J. Sponer, P. Sulc, N. Stephanopoulos*, H. Yan*, The influence of Holliday junction sequence and dynamics on DNA crystal self-assembly, Nat. Commun. 13, 3112, (2022).r
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L. Liu, F. Hong, H. Liu, X. Zhou, S. Jiang, P. Sulc, J. Jiang*, H. Yan*, A localized DNA Finite State Machine with Temporal Resolution, Science Advances 8, eabm9530, (2022).r
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J. Bohlin', E. Poppleton', M. Matthies', J. Procyk', A. Mallya, H. Yan, P. Sulc*, Design and simulation of DNA, RNA, and hybrid protein-nucleic acid nanostructures with OxView, Nature Protocols 17, 1762�1788, (2022).r
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C. Zhang*, X. Ma, X. Zheng, Y. Ke, K. Chen, D. Liu, Z. Lu, J. Yang*, H. Yan*, Programmable Allosteric DNA Regulations for Molecular Networks and Nanomachines, Science Advances 8, eabl4589, (2022).r
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S. Dey', A. Dorey', L. Abraham', Y. Xing, I. Zhang, F. Zhang, S. Howorka*, H. Yan*, A Reversibly Gated Protein-Transporting Membrane Channel Made of DNA, Nat. Commun. 13, 2271, (2022).r
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H. Liu, F. Hong, F. Smith, J. Goertz, T. Ouldridge, M. Stevens, H. Yan, P. Sulc*, Kinetics of RNA and RNA:DNA hybrid strand displacement, ACS Synth. Biol. 10, 3066-3073, (2021).r
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Y. Liu, L. Ma, S. Jiang, C. Han, P. Tang, H. Yang, X. Duan, N. Liu*, H. Yan*, X. Lan*, DNA Programmable Self-Assembly of Planar, Thin-Layered Chiral Nanoparticle Superstructures with Complex Two-Dimensional Patterns, ACS Nano 15, 16664-16672, (2021).r
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T. Yuan, Y. Shao, X. Zhou, Q. Liu, Z. Zhu, B. Zhou, Y. Dong, N. Stephanopoulos, S. Gui*, H. Yan*, D. Liu*, Highly Permeable DNA Supramolecular Hydrogel Promotes Neurogenesis and Functional Recovery after Completely Transected Spinal Cord Injury, Advanced Materials 33, 2102428, (2021).r
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Y. Zhang, Z. Qu, . Jiang, Y. Liu, R. Narayanan, D. Williams, X. Zuo, L. Wang, H. Yan, H. Liu* & C. Fan, Prescribing Silver Chirality with DNA Origami, J. Am. Chem. Soc 143, 8639-8646, (2021).r
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S. Jiang, N. Pal, F. Hong, N. E. Fahmi, H. Hu, M. Vrbanac, H. Yan*, N. G. Walter*, Y. Liu*, Regulating DNA Self-Assembly Dynamics with Controlled Nucleation, ACS Nano 15, 5384-5396, (2021).r
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S. Dey, C. Fan*, K. V. Gothelf*, J. Li*, C. Lin*, L. Liu, N. Liu*, M. A. D. Nijenhuis, B. Sacca*, F. C. Simmel*, H. Yan* & P. Zhan, DNA Origami, Nat. Rev. Methods Primers 1, 13, (2021).r
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S. Jiang, Z. Ge, S. Mou, H. Yan*, C. Fan*, Designer DNA Nanostructures for Therapeutics, Chem 7, 1156-1179, (2020).r
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G. Yao', F. Zhang', F. Wang', T. Peng, H. Liu, E. Poppleton, P. Sulc, S. Jiang, L. Liu, C. Gong, X. Jing, X. Liu, L. Wang, Y. Liu, C. Fan*, H. Yan*, Meta-DNA Structures, Nat. Chem. 12, 1067-1075, (2020).r
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C.R. Simmons', T. MacCulloch', F. Zhang, Y. Liu, N. Stephanopoulos & H. Yan, A Self-Assembled Rhombohedral DNA Crystal Scaffold with Tunable Cavity Sizes and High Resolution Structural Detail, Angew. Chem. Int. Ed. 59, 18619-18626, (2020).r
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S. Jiang, F. Zhang, H. Yan, Complex assemblies and crystals guided by DNA, Nat. Mater. 19, 694-700, (2020).r
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J. Georges, X. Qi, X. Liu, Y. Zhou, E. C. Woolf, A. Valeri, Z. Al-Atrache, E. Belykh, B. Feuerstein, M. Preul, A. C. Scheck, M. Reiser, T. Anderson, J. Gopez, D. Appelt, S. Yocom, J. Eschbacher, H. Yan, P. Nakaji, A Fluorescent Aptamer Provides Rapid and Specific Ex Vivo Diagnosis of Central Nervous System Lymphoma from Rodent Xenograft Biopsies, J. Neurosurg. 134, 1728-1737, (2020).r
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J. Li', J. Dai', S. Jiang', M. Xie', T. Zhai, L. Guo, S. Cao, S. Xing, Z. Qu, Y. Zhao, F. Wang, Y. Yang, L. Liu, X. Zuo, L. Wang*, H. Yan*, C. Fan*, Encoding quantized fluorescence states with fractal DNA frameworks, Nat. Commun. 11, 2185, (2020).r
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X. Qi, X. Liu, L. Matiski, R. Rodriguez Del Villar, T. Yip, F. Zhang, S. Sokalingam, S. Jiang, L. Liu, H. Yan, Y. Chang, RNA Origami Nanostructures for Potent and Safe Anti-Cancer Immunotherapy, ACS Nano 14, 4727-4740, (2020).r
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F. Hong, D. Ma, K, Wu, L.A. Mina, R.C. Luiten, Y. Liu, H. Yan*, A.A. Green*, Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators, Cell 180, 1018-1032, (2020).r
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G. Yao, J. Li, Q. Li, X. Chen, X. Liu, F. Wang, Z. Qu, Z. Ge, R.P. Narayanan, D. Williams, H. Pei, X. Zuo, L. Wang, H. Yan, B.L. Feringa*, C. Fan*, Programming nanoparticle valence bonds with single-stranded DNA encoders, Nature Materials 19, 781-788, (2020).r
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C. Zhang*, Z. Wang, Y. Liu, J. Yang, X. Zhang, Y. Li, L. Pan, Y. Ke*, H. Yan*, Nicking-Assisted Reactant Recycle to Implement Entropy-Driven DNA Circuit, J. Am. Chem. Soc. 141, 17189-17197, (2019).r
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Z. Zhao, C. Wang, H. Yan,* Y. Liu*, Soft Robotics Programmed with Double Crosslinking DNA Hydrogels, Advanced Functional Materials 1905911, (2019).r
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X. Jing, F. Zhang, P. Pan, X. Dai, J. Li, L. Wang, H. Yan, C. Fan, Solidifying framework nucleic acids with silica, Nature Protocols 14, 2416-2436, (2019).r
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X. Wang, A. Chandrasekaran, R. Arun, Z. Shen, Y. Ohayon, T. Wang, M. Kizer, R. Sha, C. Mao, H. Yan, X. Zhang, S. Liao, B. Ding, B. Chakraboty, N. Jonoska, D. Niu, H. Gu, J. Chao, X. Gao, Y. Li, T. Ciengshin, N. Seeman, Paranemic Crossover DNA: There and Back Again, Chemical Reviews 119, 6273-6289, (2019).r
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Y. Zhou, X. Qi, Y. Liu, F. Zhang, H. Yan, DNA Nanoscaffold-Assisted Selection of Femtomolar Bivalent Aptamers for Human-Thrombin with Potent Anticoagulant Activity, ChemBioChem 20, 2494-2503 (2019).r
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S. Mandal', X. Zhou', S. Lin, H. Yan, N. Woodbury, Directed Energy Transfer through DNA-Templated J-aggregates, Bioconjugate Chemistry 30, 1870-1879, (2019).r
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X. Zhou', S. Mandal', S. Jiang, S. Lin, J. Yang, Y. Liu, D. Whitten, N. Woodbury, H. Yan, Efficient Long-rnage, Directional Energy Transfer through DNA-Templated Dye Aggregates, J. Am. Chem. Soc. 141, 8473-8481, (2019).r
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L. Xin, M. Lu, S. Both, M. Pfeifer, M. Urban, C. Zhou, H. Yan, T. Weiss, N. Liu, K. Lindfors, Watching a Single Fluorofphore Molecule Walk into a Plasmonic Hotspot, ACS Photonics 6, 985-993, (2019).r
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Y. Xu, S. Jiang, C. Simmons, R. Narayanan, F. Zhang, A. Aziz, H. Yan, N. Stephanopoulos*, Tunable Nanoscale Cages from Self-Assembling DNA and Protein Building Blocks, ACS Nano 13, 3545-3554, (2019).r
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H. Jun', F. Zhang', T. Shepherd, S. Ratanalert, X. Qi, H. Yan, M. Bathe*, Autonomously designed free-form 2D DNA origami, Science Advances 5, eaav0655, (2019).r
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Z. Ge, J. Fu, M. Liu, S. Jiang, A. Andreoni, X. Zuo, Y. Liu, H. Yan*, C. Fan*, Constructing Submonolayer DNA Origami Scaffold on Gold Electrode for Wiring of Redox Enzymatic Cascade Pathways, ACS Appl. Mater. Interfaces 11, 13881-13887 (2019).r
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Z. Ge, Z. Su, C. R. Simmons, J. Li, S. Jiang, W. Li, Y. Yang, Y. Liu*, W. Chiu, C. Fan*, H. Yan*, Redox Engineering of Cytochrome c using DNA Nanostructure-Based Charged Encapsulation and Spatial Control, ACS Appl. Mater. Interfaces 11, 13874-13880 (2019).r
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F. Hong, S. Jiang, X. Lan, R. Narayanan, P. Sulc, F. Zhang*, Y. Liu*, H. Yan*, Layered-Crossover Tiles with Precisely Tunable Angles for 2D and 3D DNA Crystal Engineering, J. Am. Chem. Soc. 140, 14670-14676, (2018).r
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X. Qi', F. Zhang'*, Z. Su', S. Jiang, D. Han, B. Ding, Y. Liu, W. Chiu, P. Yin, H. Yan*, Programing Molecular Topologies from Single-stranded Nucleic Acids, Nature Commun. 9, 4579, (2018).r
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D. Jiang', Z. Ge', H. Im, C. England, D. Ni, J. Hu, L. Zhang, C. Kutyreff, Y. Yan, Y. Liu, S. Cho, J. Engle, J. Shi, P. Huang, C. Fan*, H. Yan*, W. Cai*, DNA-origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury, Nature Biomed. Eng. 2, 865-877, (2018).r
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X. Lan*, T. Liu, Z. Wang, A. Govorov*, H. Yan, Y. Liu*, DNA-Guided Plasmonic Helix with Switchable Chirality, J. Am. Chem. Soc. 140, 11763-11770, (2018).r
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F. Zhang', C. Simmons', J. Gates, Y. Liu, H. Yan*, Self-Assembly of a 3D DNA Crystal Structure with Rationally Designed Six-Fold Symmetry, Angew Chem Int Ed. 57, 12504-12507, (2018).r
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X. Liu', F. Zhang', X. Jing', M. Pan, P. Liu, W. Li, B. Zhu, J. Li, H. Chen, L. Wang, J. Lin, Y. Liu, D. Zhao, H. Yan* and C. Fan*, Complex silica composite nanomaterials templated with DNA origami, Nature 559, 593-598, (2018).r
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J. Li, A. Johnson-Buck, Y. Yang, W. Shih, H. Yan, N. Walter*, Exploring the speed limit of toehold exchange with a cartwheeling DNA acrobat, Nature Nanotechnol. 13, 723-729, (2018).r
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S. Li, Q. Jiang, S. Liu, Y. Zhang, Y. Tian, C. Song, J. Wang, Y. Zou, G. J. Anderson, J. Han, Y. Chang, Y. Liu, C. Zhang, L. Chen, G. Zhou, G. Nie*, H. Yan*, B. Ding*, Y. Zhao*, A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo, Nature Biotechnology 36, 258-264, (2018).r
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E. Boulais, N. Sawaya, R. Veneziano, A. Andreoni, J. Banal, T. Kondo, S. Mandal, S. Lin, G. Schlau-Cohen, N. Woodbury, H. Yan*, A. Aspuru-Guzik*, M. Bathe*, Programmed coherent coupling in a synthetic DNA-based excitonic circuit, Nature Materals 17, 159-166, (2018).