个人简历

Education\r
Ph.D. Biochemistry, March 1991, University of Texas Southwestern Medical Center, Dallas, Texas, USA\r
B.S. Biology, July 1984, Beijing Normal University, Beijing, China\r
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Professional Experience\r
2004 NAS Award in Molecular Biology, elected to National Academy of Sciences, USA\r
2003- Investigator, National Institute of Biological Sciences,Beijing, China\r
2002- present Investigator, Howard Hughes Medical Institute\r
2001- present George L. MacGregor Distinguished Chair Professor in Biomedical Science, UT-Southwestern\r
1999-2001 Associate Professor, Department of Biochemistry, Universityof Texas Southwestern Medical Center at Dallas\r
1997-2002 Assistant Investigator, Howard Hughes Medical Institute\r
1996-1999 Assistant Professor, Department of Biochemistry, Universityof Texas Southwestern Medical Center at Dallas\r
1995-1996 Assistant Professor, Department of Biochemistry, Emory University School of Medicine, studies on the biochemical pathway of apoptosis in mammalian cells\r
1991-1995 Postdoctoral research with Drs. Joseph L. Goldstein and Michael S. Brown, UT-Southwestern, studies on sterol regulation of gene expression\r
1986-1991 Ph.D.dissertation research with Dr. Richard A. Padgett, UT-Southwestern. Studies on mammalian pre-messenger RNA splicing\r
1984-1985 Undergraduate thesis with Professor Shaobai Xue, BeijingNormal University. Studies on mammalian cell cycle control\r
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AWARDS AND FELLOWSHIPS\r
2006 The Shaw Prize in Life Science and Medicine\r
2004 NAS Award in Molecular Biology, The National Academy of Sciences, USA\r
2004 Outstanding Achievement Award, American Association of Cancer Research\r
2003 Norman Hackerman Award, The Welch Foundation\r
2001 Paul Marks Prize, Memorial Sloan-Kettering Cancer Center\r
2000 Eli Lilly Award, American Chemical Society\r
2000 Schering-Plough Award, American Society of Biochemistry and Molecular Biology\r
1999 Young Investigator Award, Society of Chinese Biomedical Scientist in America\r
1998 Wilson S. Stone Memorial Award, MD-Anderson Cancer Center\r
1991 Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellowship\r
1984 CUSBEA (Chinese-United States Biochemistry and Molecular Biology

研究领域

""我们目前的研究是过去15年来对细胞凋亡，一种由细胞内的Caspases执行的细胞死亡形式的系统研究的延伸。这些研究经历使我们认识到细胞凋亡仅仅只是细胞自我灭亡的形式之一，另外还有一些细胞死亡的其它方式，它们通过与细胞凋亡相似而又不同的细胞内成份和调节机制来完成。这其中包括我们目前注意到的由肿瘤坏死因子受体诱发的细胞坏死。我们发现了一种在肿瘤坏死因子受体下游的激酶Rip3在这种细胞死亡形式中起着关键作用。我们正在研究Rip3是如何杀死细胞，以及这个过程与细胞凋亡以及其它形式的细胞死亡间有何联系。""""

近期论文

Min Fang, Zhirong Shen, Song Huang, Liping Zhao, She Chen, Tak W. Mak and Xiaodong Wang (2010) The ER UDPase ENTPD5 promotes protein N-Glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell 143, 711-724.\r
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Shang L, Chen S, Du F, Li S, Zhao L, Wang X. (2011). Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc. Natl. Acad. Sci. USA.\r
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Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X. (2012). Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148(1-2):213-27.\r
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Wang Z, Jiang H, Chen S, Du F, Wang X. (2012). The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148(1-2):228-43.\r
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Gelin Wang, Xiaoming Wang, Hong Yu, Shuguang Wei, Noelle Williams, Daniel L Holmes, Randal Halfmann, Jacinth Naidoo, Lai Wang, Lin Li, She Chen, Patrick Harran, Xiaoguang Lei, and Xiaodong Wang (2013). Small-molecule activation of the TRAIL receptor DR5 inhuman cancer cells. Nature Chem. Biol. 9, 84–89\r
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Wang H, Sun L, Su L, Rizo J, Liu L, Wang LF, Wang FS, and Wang X, Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3 Molecular Cell, DOI: 10.1016/j.molcel.2014.03.003, Apr. 10, 2014\r
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Xian Jiang, Hui Jiang, Zhirong Shen, Xiaodong Wang.(2014). Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis. Proc Natl Acad Sci U S A 2014 Oct 1;111(41):14782-7.\r
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Li D, Xu T, Cao Y, Wang H, Li L, Chen S, Wang X, Shen Z.(2015). A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc Natl Acad Sci U S A 2015 Apr 7;112(16):5017-22.\r
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Xian Jiang, Li Li, Zhengxin Ying, Chenjie Pan, Shaoqiang Huang, Lin Li, Miaomiao Dai, Bo Yan, Ming Li, Hui Jiang, She Chen, Zhiyuan Zhang, Xiaodong Wang.A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway .Molecular Cell, DOI: http://dx.doi.org/10.1016/j.molcel.2016.06.016, July 21, 2016\r
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Li Li,Xian Jiang,Shaoqiang Huang,Zhengxin Ying, Zhaolan Zhang, Chenjie Pan,Sisi Li, Xiaodong Wang, Zhiyuan Zhang.Discovery of Highly Potent 2‑ Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment.ACS Medicinal Chemistry Letter,DOI:10.1021/acsmedchemlett.6b00489, March 1,2017\r
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Bo Yan, Lei Liu, Shaoqiang Huang, Yan Ren, Huayi Wang, Zhenglin Yao, Lin Li, She Chen, Xiaodong Wang and Zhiyuan Zhang.Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein.Chem. Commun., DOI: 10.1039/c7cc00667e, April 4, 2017\r
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Dianrong Li, LingjunMeng, Tao Xu, YaningSu, Xiao Liu, Zhiyuan Zhang,Xiaodong Wang.RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system.eLife, DOI: 10.7554/eLife.27692, August 15,2017\r
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Ying Z, Pan C, Shao T, Liu L, Li L, Guo D, Zhang S, Yuan T, Cao R, Jiang Z, Chen S, Wang F, Wang X.Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury.Molecular cell, DOI：10.1016/j.molcel.2018.09.011, Oct. 18, 2018\r
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Sitao Zhang S, Yaning Su, Zhengxin Ying, Dejia Guo, Chenjie Pan, Jia Guo, Ziye Zou, Lei Wang, Ze Zhang, Zhaodi Jiang, Zhiyuan Zhang, and Xiaodong Wang (2019).RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation.Proc. Natl. Acad. Sci. USA 116:5675-5680. doi: 10.1073.\r
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Ran Cao, Li Li, Zhengxin Ying, Zichen Cao, Yongfen ma, Xiaoxu Mao, Jiaojiao Li, Xiangbing Qi, Zhiyuan Zhang, and Xiaodong Wang (2019).A small molecule protects mitochondrial integrity by inhibiting mTOR activity.Proc. Natl. Acad. Sci. USA 116:23332-23338. doi: 10.1073/pnas.1911246116.\r
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Dianrong Li, Jie Chen, Youwei Ai, Xiaoqiong Gu, Li Li, Di Che, Zhaodi Jiang, Lin Li, She Chen, Huangwei Huang, Jiawen Wang, Tao Cai, Yang Cao, Xingbin Qi, and Xiaodong Wang (2019).Estrogen-related hormones induce apoptosis by stabilizing Schlafen-12 protein turnover.Mol. Cell 75, 1103-1116.\r
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Dianrong Li, Youwei Ai, Jia Guo, Baijun Dong, Lin Li, Gaihong Cai, She Chen, Dan Xu, Fengchao Wang, and Xiaodong Wang (2020).Casein kinase 1G2 suppresses necroptosis- promoted testis aging by inhibiting receptor-interacting kinase 3.eLife 9: e61564 doi: 10.7554/eLife.61564\r
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Bo Yan, Youwei Ai, Ze Zhang, Qi Sun, Yan Ma, Zhiyuan Zhang and Xiaodong Wang (2020).Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1.Mol. Cell Dec 8; S1097-2765(20)30802-9. doi: 10.1016/j.molcel.2020.11.024.