个人简历

教育经历\r
1994 兰州大学医学院 医学学士学位\r
1997 兰州生物制品研究所 免疫学硕士学位\r
2001 中国协和医科大学中国医学科学院 病原生物学博士学位\r
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工作经历\r
2015.3- 北京生命科学研究所资深研究员\r
2007.10-2015.2 北京生命科学研究所研究员\r
2004.6-2007.9 哈佛大学医学院 Instructor\r
2001.9-2004.5 哈佛大学医学院 博士后

研究领域

""本实验室的研究兴趣集中于重要病毒感染的分子机制及其防治。近年来，我们主要致力于乙肝病毒（HBV）研究。乙型肝炎是危害人类健康的严重传染病。全球估计有HBV感染者2.4亿人，其中我国约有9300万人。慢性HBV感染是导致肝硬化、肝癌的重要病因。丁型肝炎病毒（HDV）是HBV的卫星病毒,在所有HBV感染者中，约有1500万人同时感染HDV。我们发现HBV及HDV感染肝细胞的关键受体是钠离子-牛磺胆酸共转运蛋白（NTCP）；稳定表达人NTCP的HepG2细胞系(HepG2-NTCP)已成为HBV相关基础病毒学研究和抗病毒药物研发的重要平台。目前，对乙肝感染的科学研究及药物开发已进入一个充满生机的新时代。本实验室综合运用病毒学，生物化学，免疫学，化学生物学等多学科方法深入剖析HBV及HDV感染过程的分子基础，以帮助理解其病理机制。我们也希望研发新的抗病毒药物，为最终有效解除患者的病痛而努力。此外，我们也与相关实验室合作研究NTCP/胆酸等分子在感染及机体代谢过程中的相关作用。""""

近期论文

He, W.,B.Ren, F.Mao,Z.Jing,Y.Li,Y.Liu,B.Peng, H. Yan,Y.Qi,Y.Sun, J-T.Guo,J.Sui,F.Wang, andW.Li*. Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide.PLOS Pathog, 10.1371/journal.ppat.1004840, 2015.\r
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Yan, H., B. Peng, Y. Liu, G. Xu, W. He, B. Ren, Z. Jing, J. Sui, and W. Li*. Viral entry of hepatitis B and d viruses and bile salts transportation share common molecular determinants on sodium taurocholatecotransporting polypeptide. Journal of virology, 88(6): p. 3273-84, 2014.\r
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Sun, Y*., Y. Qi, C. Liu, W. Gao, P. Chen, L. Fu, B. Peng, H. Wang, Z. Jing, G. Zhong, and W. Li*. Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus. Journal of virology, 88(1):237-48, 2014.\r
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Xu, G., Z. Gao, W. He, Y. Ma, X. Feng, T. Cai, F. Lu, L. Liu, and W. Li*. microRNA expression in hepatitis B virus infected primary treeshrew hepatocytes and the independence of intracellular miR-122 level for de novo HBV infection in culture. Virology, 448: 247-54, 2014.\r
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Zhong, G., H. Yan, H. Wang, W. He, Z. Jing, Y. Qi, L. Fu, Z. Gao, Y. Huang, G. Xu, X. Feng, J. Sui, and W. Li*. Sodium taurocholatecotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes. Journal of virology, 87(12): 7176-84, 2013.\r
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Yan, H., B. Peng, W. He, G. Zhong, Y. Qi, B. Ren, Z. Gao, Z. Jing, M. Song, G. Xu, J. Sui, and W. Li*. Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholatecotransporting polypeptide. Journal of virology, 87(14): 7977-91, 2013.\r
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Liu, F., M. Campagna, Y. Qi, X. Zhao, F. Guo, C. Xu, S. Li, W. Li, T.M. Block, J. Chang, and J.T. Guo*. Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNAminichromosomes.PLoSPathog, 9(9): p. e1003613, 2013.\r
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Lin, S., H. Yan, L. Li, M. Yang, B. Peng, S. Chen, W. Li*, and P.R. Chen*. Site-Specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus. AngewandteChemie International Edition, 52(52): 13970-13974, 2013.\r
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Jemielity, S., J.J. Wang, Y.K. Chan, A.A. Ahmed, W. Li, S. Monahan, X. Bu, M. Farzan, G.J. Freeman, D.T. Umetsu, R.H. Dekruyff, and H. Choe*. TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. PLoSPathog, 9(3): e1003232, 2013.\r
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Yan, H., G. Zhong, G. Xu, W. He, Z. Jing, Z. Gao, Y. Huang, Y. Qi, B. Peng, H. Wang, L. Fu, M. Song, P. Chen, W. Gao, B. Ren, Y. Sun, T. Cai, X. Feng, J. Sui, and W. Li*. Sodium taurocholatecotransporting polypeptide is a functional receptor for human hepatitis B and D virus.eLife, 1: e00049, 2012.\r
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Chen, P., Z. Song, Y. Qi, X. Feng, N. Xu, Y. Sun, X. Wu, X. Yao, Q. Mao, X. Li, W. Dong, X. Wan, N. Huang, X. Shen, Z. Liang, and W. Li*. Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B 2. J BiolChem, 287(9): 6406-20, 2012.\r
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Huang, Z., Y. Feng, D. Chen, X. Wu, S. Huang, X. Wang, X. Xiao, W. Li, N. Huang, L. Gu, G. Zhong, and J. Chai*. Structural basis for activation and inhibition of the secreted chlamydia protease CPAF. Cell Host Microbe, 4(6):529-42, 2008.\r
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Huang, I.-C., W. Li, J. Sui, W. Marasco, H. Choe, and M. Farzan*. Influenza A virus neuraminidase limits viral superinfection. Journal of virology, 82(10): 4834-4843, 2008.\r
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Radoshitzky, S.R., J. Abraham, C.F. Spiropoulou, J.H. Kuhn, D. Nguyen, W. Li, J. Nagel, P.J. Schmidt, J.H. Nunberg, N.C. Andrews, M. Farzan, and H. Choe*. Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. Nature, 446(7131): p. 92-6, 2007.\r
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Li, W., J. Sui, I. Huang, J.H. Kuhn, S.R. Radoshitzky, W.A. Marasco, H. Choe, and M. Farzan*. The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2. Virology, 367(2): 367-374, 2007.\r
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Zhang, L., F. Zhang, W. Yu, T. He, J. Yu, C.E. Yi, L. Ba, W. Li, M. Farzan, Z. Chen, K.Y. Yuen, and D. Ho*. Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals. J Med Virol, 78(1): 1-8, 2006.\r
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Li, F., M. Berardi, W. Li, M. Farzan, P.R. Dormitzer, and S.C. Harrison*. Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain. Journal of virology, 80(14): 6794-6800, 2006.\r
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Kuhn, J.H., S.R. Radoshitzky, A.C. Guth, K.L. Warfield, W. Li, M.J. Vincent, J.S. Towner, S.T. Nichol, S. Bavari, H. Choe, M.J. Aman, and M. Farzan*. Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor. J BiolChem, 2006. 281(23): 15951-8.\r
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Huang, I.-C., B.J. Bosch, F. Li, W. Li, K.H. Lee, S. Ghiran, N. Vasilieva, T.S. Dermody, S.C. Harrison, and P.R. Dormitzer*. SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J BiolChem, 281(6): 3198-3203, 2006.\r
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He, Y., J. Li, W. Li, S. Lustigman, M. Farzan, and S. Jiang*. Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein. Journal of Immunology, 176(10): 6085-6092, 2006.