个人简历
Professional Experience\r2017.11-Current Assistant Investigator, National Institute of Biological Sciences, Beijing\r2014.10-2017.10 Post-doctoral Fellow, The Scripps Research Institute, La Jolla, San Diego, CA, USA.Advisor: Prof. Phil S. Baran\r2013.7-2014.9 Post-doctoral Fellow, National Institute of Biological Science (NIBS), Beijing, China. Advisor: Prof. Xiaoguang Lei\r\rEducation\r2008-2013 Ph.D. in Organic Synthesis, National Institute of Biological Science (NIBS), Beijing, China. & Tianjin University, Tianjin, China. Advisor: Prof. Xiaoguang Lei\r2004-2008 B.S. in Pharmaceutical Engineering, Qingdao University of Science and Technology, Qingdao, China. Advisor: Prof. Fengke Yang\r\rHonors\r2020 Thieme Chemistry Journals Award\r2013 Storm International Diversity (CSID) Fellowship for Gordon Research Conference\r2012 National Scholarship for Excellence in Scientific Research\r2012 Graduate Student Award Sponsored by Baoshan Iron and Steel Company
研究领域
"""""化学小分子在认知，干扰与调节生物过程中发挥着重要的作用。我们课题组致力于在开拓合成化学空间的基础上，利用获得的活性小分子发现与人类重大疾病相关的药物作用靶标和先导化合物。同时设计合成具有重要生物学利用价值的化学工具分子。具体的研究内容包括：\r\r（1）利用新型催化体系研究新颖的化学键构建方法，为化学分子的合成提供更理想的策略。\r（2）选择与重大疾病相关的天然产物进行合成及活性优化，进而推动创新药物的研究;\r（3）探索活性天然小分子的生物学作用机制和其作用靶标;\r（4）设计合成能够选择性标记，追踪生物大分子或识别其相互作用的化学工具分子。"
近期论文
Zhuo, J.; Zhu, C.; Wu, J.; Li, Z.; Li, C. “Reductive Radical Annulation Strategy toward Bicyclo[3.2.1]octanes: Synthesis of ent-Kaurane and Beyerane Diterpenoids” J. Am. Chem. Soc. ASAP.\r\rYang, S.;# Chen, C.;# Chen, J.#; Li, C. “Total Synthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin” J. Am. Chem. Soc. ASAP\r\rLi, Y.; Wang, Z.; Li, L.; Tian, X.; Shao, F.; Li, C. “Chemoselective and Diastereoselective Synthesis of C-Aryl-Nucleoside Analogues by Nickel-Catalyzed Cross-Coupling of Furanosyl Acetates with Aryl Iodides” Angew. Chem. Int. Ed. DOI: 10.1002/anie.202110391.\r\rZhang, Y.; Sun, W.; Li, C. “Nickel-Catalyzed Paired Electrochemical Cross-Coupling of Aryl Halides with Nucleophiles” Synthesis DOI: 10.1055/a-1581-0934.\r\rLi, Z.; Sun, W.; Wang, X.; Li, L; Zhang, Y.; Li, C. “Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides” J. Am. Chem. Soc. 2021, 143, 3536-3543.\r\rXu, G.;# Wu, J.;# Li, L.; Lu, Y.; Li, C. “Total Synthesis of (-)-Daphnezomines A and B” J. Am. Chem. Soc. 2020, 142, 15240–15245.\r\rZhuo, J.;# Zhang, Y.; # Li, Z.; Li, C. “Nickel-Catalyzed Direct Acylation of Aryl and Alkyl Bromides with Acylimidazoles” ACS Catal. 2020, 10, 3895-3903.\r\rZhang, J.;# Li, Z.;# Zhuo, J.; Cui, Y.; Han, T.; Li, C. “Tandem Decarboxylative Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (-)-Longirabdolactone, and (-)-Effusin” J. Am. Chem. Soc. 2019, 141, 8372-8380.\r\rTakahira, Y.; Chen, M.; Kawamata, Y.; Mykhailiuk, P.; Nakamura, H. Peters, B. K.; Reisberg, S. H.; Li, C.; Chen, L.; Hoshikawa, T.; Shibuguchi, T.; Baran, P. S. Electrochemical C(sp3)-H Fluorination. Synlett. 2019, 30, 1178.\r\rKawamata, Y.; Vantourout, J. C.; Hickey, D. P.; Bai, P.; Chen, L.; Hou, Q.; Qiao, W.; Barman, K.; Edwards, M. A.; Garrido-Castro, A. F.; deGruyter, J. N.; Nakamura, H.; Knouse, K.; Qin, C.; Clay, K. J.; Bao, D.; Li, C.; Starr, J. T.; Garcia-Irizarry, C.; Sach, N.; White, H. S.; Neurock, M.; Minteer, S. D.; Baran, P. S. Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications. J. Am. Chem. Soc. 2019, 141, 6392.\r\rLi, C.#; Kawamata, Y.#; Nakamura, H.; Vantourout, J. C.; Liu, Z.; Hou, Q.; Bao, D.; Star, J. T.; Chen, J.; Yan, M.; Baran, P. S.* “Electrochemically Enabled, Ni-Catalyzed Amination” Angew. Chem. Int. Ed. 2017, 56, 13088.\r\rLi, C.#; Wang, J.#; Barton, L. M.; Yu, S.; Tian, M.; Peters, D. S.; Kumar, M.; Yu, A. W.; Johnson, K. A.; Chatterjee, A. K.; Yan, M.; Baran, P. S.* “Decarboxylative Borylation” Science, 2017, eaam7355. (Article).\r\rQin, T.#; Cornella, J.#; Li, C.#; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.;Eastgate, M. D.; Baran, P. S.* “A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents” Science, 2016, 352, 801-805. (Highlighted in Angew. Chem. Int. Ed. 2016, 55, 11340; Synfacts 2016, 12, 0723)\r\rLi, C.; Jones, A. X.; Lei, X.* “Synthesis and mode of action of oligomeric sesquiterpene lactones” Nat. Prod. Rep. 2016, 33, 602-611.\r\rLi, D.#; Li, C.#; Li, L.; Chen, S.; Wang, L.; Li, Q.; Wang, X.; Lei, X.*; Shen, Z.* “Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis” Cell Chemical Biology, 2016, 23, 257-266. (Featured Article)\r\rHong, B.#; Li, C.#; Wang, Z.; Chen, J.; Li, H.*; Lei, X.* “Enantioselective Total Synthesis of (−)-Incarviatone A” J. Am. Chem. Soc. 2015, 137, 11946-11949. (News story describing this work was highlighted in Chem. & Eng. News 2015, 93, 35)\r\rDao, H. T.; Li, C.; Michaudel, Q.; Maxwell, B. D.; Baran, P. S.* “Hydromethylation of Unactivated Olefins” J. Am. Chem. Soc. 2015, 137, 8046-8049.\r\rDong, T.#; Li, C.#; Wang, X.; Dian, L.; Zhang, X.; Li, L.; Chen, S.; Cao, R.; Li, L.; Huang, N.; He, S.;* Lei, X.* “Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine” Nature Commun. 2015, 6, 6522.(News story describing this work was highlighted in Chem. & Eng. News 2015, 15, 39)\r\rLi, C.#; Dong, T.#; Li, Q.; Lei, X.* “Probing the Anticancer Mechanism of (−)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation” Angew. Chem. Int. Ed. 2014, 53, 12111-12115.\r\rLi, C.; Lei, X.* “Strategies toward the Biomimetic Syntheses of Oligomeric Sesquiterpenoids” J. Org. Chem. 2014, 79, 3289-3295.\r\rLi, C.; Dong, T.; Dian, L.; Zhang, W.; and Lei, X.* “Biomimetic Syntheses and Structural Elucidation of the Apoptosis-Inducing Sesquiterpenoid Trimers: (-)-Ainsliatrimers A and B” Chem. Sci. 2013, 4, 1163-1167.
