个人简历

Education\r
2005-2009 Ph.D. Organic Chemistry/Biochemistry，Department of Biochemistry，University of Texas Southwestern Medical Center at Dallas (Advisor: Joseph M. Ready)\r
2001-2004 M.S. Organic Chemistry, Department of Chemistry, Tongji University\r
1997-2001 B.S. Applied Chemistry, School of Chemistry and Chemical Engineering, University of Jinan\r
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Professional Experience\r
2013- Director of Chemistry Center, National Institute of Biological Sciences, Beijing, China\r
Principal investigator, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University\r
2010-2013 Postdoctoral Fellow, Organic Chemistry and Medicinal Chemistry, University of Texas Southwestern Medical Center at Dallas.(Advisors: Uttam Tambar/David Chuang)\r
2009-2010 Postdoctoral Fellow, Organic Chemistry，University of Illinois at Urbana-Champaign.\r
2004-2005 Research Assistant, Organic synthesis/Medicinal chemistry，Shanghai Institute of Organic Chemistry, Chinese Academy of Science. (Advisor: Prof. Dawei Ma)

研究领域

"""""Our lab is focused on the interface of biocatalysis

近期论文

Yadong Gao, Chao Yang, Sonlin Bai, Xiaolei Liu, Qingcui Wu, Chao jiang*, Xiangbing Qi*, “Visible-light-induced Nickel-catalyzed Cross-coupling with Alkylzirconocenes from Unactivated Alkenes” Chem, Dec.12, 2019. DOI:10.1016/j.chempr.2019.12.010\r
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Ran Cao, Li Li, Zhengxin Ying, Zichen Cao, Yongfen Ma, Xiaoxu Mao,Jiaojiao Li, Xiangbing Qi, Zhiyuan Zhang, and Xiaodong Wang*.”A small molecule protects mitochondrial integrity by inhibiting mTOR activity” Proceedings of the National Academy of Sciences, Latest Articles. October 21, 2019.\r
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Xiaofei Shen#, Lin Zhao#, Peihao Chen#, Yanqiu Gong, Dingdong Liu, Xia Zhang, Lunzhi Dai, Qingxiang Sun, Jizhong Lou, Zhong Jin, Baohua Zhang, Dawen Niu, Ceshi Chen, Xiangbing Qi, Da Jia* “A thiazole-derived oridonin analog exhibits antitumor activity by directly and allosterically inhibiting STAT3” DOI: 10.1074/jbc.RA119.009801 (# Equal Contribution)\r
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Qiqi Chu, Changfu Yao, Xiangbing Qi, Barry Raymond Stripp, Nan Tang* “STK11 is required for the normal program of ciliated cell differentiation in airways” Cell Discovery (2019) 5:36, 1-16. DOI: https://doi.org/10.1038/s41421-019-0104-z\r
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Dianrong Li, Jie Chen, Youwei Ai, Xiaoqiong Gu, Li Li, Di Che, Zhaodi Jiang, Lin Li, She Chen, Huangwei Huang, Jiawen Wang, Tao Cai, Yang Cao, Xiangbing Qi, Xiaodong Wang*, “Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover” Molecular Cell,2019, 1103. DOI: https://doi.org/10.1016/j.molcel.2019.06.040\r
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Meiyi Zhou, Shao Jing, Cheng-Yang Wu, Le Shu, Weibing Dong, Yunxia Liu, Mengping Chen, R. Max Wynn, Jiqiu Wang, Ji Wang, Wen-Jun Gui, Xiangbing Qi, Aldons J. Lusis, Zhaoping Li, Weiqing Wang, Guang Ning, Xia Yang, David T. Chuang, Yibin Wang, Haipeng Sun*, “Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance” Diabetes 2019 Jun; db180927. https://doi.org/10.2337/db18-0927\r
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Lei Zhang, Ye Zhang, Wenting Li, Xiangbing Qi*, “Total Synthesis of (-)-Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade” Angew. Chem. Int. Ed. 2019, https://doi.org/10.1002/anie.201900156.\r
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Hang Fu, Nan Liu, Qiang Dong, Chunxiao Ma, Jing Yang, Jun Xiong, Zhuqiang Zhang, Xiangbing Qi, Chang Huang & Bing Zhu*. “SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization” Cell Research 2019, 254-257\r
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Yu Zhou, Yuanxun Wang, Pengfei Li, Xi-Ping Huang, Xiangbing Qi, Yunfei Du*, and Niu Huang*. “Exploring Halogen Bonds in 5-Hydroxytryptamine 2B Receptor–Ligand Interactions” ACS Med. Chem. Lett., 2018, 9 (10), pp 1019-1024.\r
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Chao Wei, Xiao Han, Danwei Weng, Qiru Feng, Xiangbing Qi, Jin Li & Minmin Luo*. “Response dynamics of midbrain dopamine neurons and serotonin Interactions neurons to heroin, nicotine, cocaine, and MDMA” Cell Discovery，4 : 60 (2018) 1019-1024.\r
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Aaron Nash, Xiangbing Qi, Pradip Maity, Kyle Owens, and Uttam K. Tambar*. “Development of the Vinylogous Pictet-Spengler Cyclization and Total Synthesis of (±)‐Lundurine A” Angew. Chem. Int. Ed., 2018, 57, 6888-6891.\r
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Rui Lin, Qiru Feng, Peng Li, Ping Zhou, Ruiyu Wang, Zhe Liu, Zhiqiang Wang, Xiangbing Qi, Nan Tang, Feng Shao, Minmin Luo*, “A hybridization-chain-reaction-based method for amplifying immunosignals” Nature Methods, 2018 (4), 275\r
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Cheng-Yang Wu, Santhosh Satapati, Wenjun Gui, R Max Wynn, Gaurav Sharma, Mingliang Lou, Xiangbing Qi, Shawn C Burgess, Craig Malloy, Chalermchai Khemtong, A Dean Sherry, David T Chuang*, Matthew E Merritt*, “A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity”, The Journal of Biological Chemistry, 2018, 293, 9604-9613\r
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Cheng-Yang Wu, Shih-Chia Tso, Jacinta L Chuang, Wen-Jun Gui, Mingliang Lou, Gaurav Sharma, Chalermchai Khemtong, Xiangbing Qi, R Max Wynn, David T Chuang*，“Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice”，Molecular Metabolism, 2018, （12）12-24\r
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Xuekai Zhang, Gang Lu, Meng Sun, Madhu Mahankali, Yanfei Ma, Mingming Zhang, Wangde Hua, Yuting Hu, Qingbing Wang, Jinghuo Chen, Gang He, Xiangbing Qi*, Weijun Shen*, Peng Liu*, Gong Chen*，“A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp 3 C− H arylation”, Nature Chemistry，2018（10）, 540-548\r
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Xueyan Ma, Peixue Li, Peihao Chen, Jinhui Li, Hongling Huang, Chao Wang, Wenjing Li, Jianping Ding, Yun Zhao, Fa-Xing Yu, Xiangbing Qi*, Lei Zhang*，“Staurosporine targets the Hippo pathway to inhibit cell growth” Journal of Molecular Cell Biology, 2018, 10, 267-269\r
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Jingjing Fu, Yadong Gao, Xiangbing Qi*, Chao Jiang* “Synthesis of Polysubstituted Pyridines and Indoles by a Palladium-Catalyzed Catellani-type Alkylation-Alkenylation Sequence” ChemistrySelect, 2018,10164\r
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Yanli Wang, Yuze Sun, Ran Cao, Dan Liu, Yuting Xie, Li Li, Xiangbing Qi*, Niu Huang*，“In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery” J. Med. Chem., 2017, 60 (20), pp 8552-8564\r
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Yaling Wu, Dingbin Tang, Na Liu, Wei Xiong, Huanwei Huang, Yang Li, Zhixiong Ma, Haijiao Zhao, Peihao Chen, Xiangbing Qi and Eric Erquan Zhang*. “Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals”, Cell Metabolism,2017, 25 (1), 73-85.\r
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Shih-Chia Tso, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Xiangbing Qi, Kristen J. Skvorak, Kenneth Dorko, Amy L. Wallace, Lorraine K. Morlock, Brendan H. Lee, Susan M. Hutson, Stephen C. Strom, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, and David T. Chuang*. “Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase” J. Biol. Chem., 2014, 289, 20583-20593.\r