个人简历

教育经历\r
1996年 北京大学技术物理系应用化学专业学士\r
1999年 中国科学院生物物理所分子生物学硕士\r
2003年 美国密西根大学医学院生物化学博士\r
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工作经历\r
2012-present 北京生命科学研究所资深研究员\r
2009-2012年 北京生命科学研究所高级研究员\r
2005-2009年 北京生命科学研究所研究员\r
2004-2005年 哈佛大学医学院博士后\r
2003-2004年 美国加洲大学圣地亚哥分校医学院博士后

研究领域

"""""我们实验室的研究兴趣集中在病原细菌感染宿主和宿主先天性免疫防御的分子机制。对于细菌感染来说，通过特殊的分泌系统向宿主细胞中注入毒素效应蛋白是病原细菌普遍采用的重要致病机制。这些效应蛋白往往以非常有效的方式作用于宿主信号转导中的关键分子，使其发生功能紊乱。效应蛋白的作用有利于细菌在宿主中的生存和进一步感染"

近期论文

Ding J, Pan X, Du L, Yao Q, Xue J, Yao H, Wang D, Li S, Shao F. (2019) Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector, Molecular Cell, 74, 1-14.\r
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Rathinam V, Zhao Y, Shao F. (2019) Innate immunity to intracellular LPS, Nature Immunology, 20, 527-533.\r
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Xu H, Shi J, Gao H, Liu Y, Yang Z, Shao F, Dong N. (2019) The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin, EMBO, 38(13):e101996.\r
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Liu W, Zhou Y, Peng T, Zhou P, Ding X, Li Z, Chen S, Hang HC, and Shao F. (2018) Ne-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function, Nature Microbiology, 3, 996-1009.\r
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Adanitsch F, Shi J, Shao F, Beyaert R, Heine H, and Zamyatina A. (2018) Synthetic glycan-based TLR4 agonists targeting Caspase-4/11 for the development of adjuvants and immunotherapeutics, Chem. Sci., 9, 3957-3963.\r
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Yang J, Zhao Y, Li P, Yang Y, Zhang E, Zhong M, Li Y, Zhou D, Cao Y, Lu M, Shao F#, Yan H#. (2018) Sequence determinants of specific pattern-recognition of bacterial ligands by the NAIP-NLRC4 inflammasome, Cell Discovery,4: 22. doi: 10.1038/s41421-018-0018-1 (# corresponding authors).\r
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Lin R, Feng Q, Li P, Zhou P, Wang R, Liu Z, Wang Z, Qi X, Tang N, Shao F, Luo M. (2018). A hybridization-chain-reaction-based method for amplifying immunosignals, Nature Methods, 15, 275-278.\r
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Xu B, Jiang M, Chu Y, Wang W, Chen D, Li X, Zhang Z, Zhang D, Fan D, Nie Y, Shao F, Wu K, Liang J. (2018) Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice, J Hepatol., 68, 773-782.\r
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Zhou Y, Huang C, Yin L, Wan M, Wang X, Li L, Liu Y, Wang Z, Fu P, Zhang N, Chen S, Liu X, Shao F, Zhu Y. (2017). Nε-Fatty acylation of Rho GTPases by a MARTX toxin effector, Science. 358, 528-531.\r
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Sheng X, You Q, Zhu H, Chang Z, Li Q, Wang H, Wang C, Wang H, Hui L, Du C, Xie X, Zeng R, Lin A, Shi D, Ruan K, Yan J, Gao GF, Shao F, Hu R. (2017) Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK, PLoS Pathogen,13(7): e1006534.\r
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Litvak Y, Sharon S, Hyams M, Zhang L, Kobi S, Katsowich N, Dishon S, Nussbaum G, Dong N, Shao F, and Rosenshine I. (2017) Epithelial cells detect functional type III secretion system of enteropathogenic Escherichia coli through a novel NF-κB signaling pathway. PLoS Pathogen, 13(7): e1006472.\r
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Dong N, Niu M, Hu L, Yao Q, Zhou R, and Shao F. (2016) Modulation of membrane phosphoinositide dynamics by the phosphatidylinositide 4-kinase activity of the Legionella LepB effector, Nature Microbiology, 2:16236.\r
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Thurston TL, Matthews SA, Jennings E, Alix E, Shao F, Shenoy AR, Birrell MA, Holden DW. (2016) Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death, Nature Communications, 7:13292.\r
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Gao W, Yang J, Liu W, Wang Y, Shao F. (2016) Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation, Proc. Natl. Acad. Sci., 113, E4857-66.\r
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Zhang Q, Zhou A, Li S, Ni J, Tao J, Lu J, Wan B, Li S, Zhang J, Zhao S, Zhao GP, Shao F, Yao YF (2016) Reversible lysine acetylation is involved in DNA replication initiation by regulating activities of initiator DnaA in Escherichia coli, Sci Rep., 6: 30837.\r
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Aubert DF, Xu H, Yang J, Gao W, Li L, Chen S, Valvano MA, Shao F. (2016) A Burkholderia type VI effector deamidates Rho GTPases to activate the Pyrin inflammasome, Cell Host & Microbe, 19, 664-674.\r
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Zhao Y, Shi J, Shi X, Wang Y, Wang F & Shao F. (2016) Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice, Journal of Experimental Medicine, 213(5), 647-56.\r
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Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. (2016) An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells, Science, 352(6290), 1232-6.\r
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Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai J. (2015) Structural and biochemical basis for induced self-propagation of NLRC4, Science, 350, 399-404.\r
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Lu Q, Xu Y, Yao Q, Niu M and Shao F. (2015) A polar-localized iron-binding protein determines the polar targeting of Burkholderia BimA autotransporter and actin tail formation, Cellular Microbiology, 17, 408–424.