个人简历

BA (Hons) Biochemistry - Oxford University (Pembroke College) - 1986
DPhil Biochemistry - Oxford University (Pembroke College) - 1990
MA - Oxford University (Pembroke College) - 1990
August 2006 - January 2011: Senior Lecturer, SIPBS, University of Strathclyde.
April 2005 - August 2006: Senior Lecturer, Department of Bioscience, University of Strathclyde.
September 2001 – April 2005: Lecturer, Department of Bioscience, University of Strathclyde.
September 1994 - August 2001: Glaxo-Jack Research Lecturer, Department of Immunology, University of Strathclyde.
April 1993 - to August 1994: SHHD funded postdoctoral research fellow in the Dept. of Pure and Applied Chemistry, Strathclyde, working with Prof. W.E. Smith. (An investigation of oxidative stress in preeclamptic erythrocytes using in vivo NMR and resonance Raman spectroscopy).
April 1992 - March 1993: AFRC funded postdoctoral research assistant to Dr C. Abell, Department of Chemistry, Cambridge. (The purification of kaurene synthase and related diterpene cyclases from Ricinus communis).
October 1989 - March 1992: AFRC funded postdoctoral research assistant to Dr B.C. Loughman and Dr R.G. Ratcliffe, Department of Plant Sciences, Oxford. (The application of in vivo NMR to the study of plant systems).

近期论文

Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. Verrastro I, Tveen-Jensen K, Woscholski R, Spickett CM, Pitt AR. Free Radic Biol Med. (2016) Jan 90: 24-34.
The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Greig FH, Ewart MA, McNaughton E, Cooney J, Spickett CM, Kennedy S (2015) Vascul Pharmacol. Nov 74:93-102.
Copper complexes as a source of redox active MRI contrast agents. Dunbar L, Sowden RJ, Trotter KD, Taylor MK, Smith D, Kennedy AR, Reglinski J, Spickett CM (2015) Biometals. Oct 28(5):903-12.
Protein lipoxidation: detection strategies and challenges. Aldini G, Domingues MR, Spickett CM, Domingues P, Altomare A, Sánchez-Gómez FJ, Oeste CL, Pérez-Sala D (2015) Redox Biol May 5:253-266.
Interfacing low-energy SAW nebulization with Liquid Chromatography-Mass Spectrometry for the analysis of biological samples. Tveen-Jensen K, Gesellchen F, Wilson R, Spickett CM, Cooper JM and Pitt AR (2015) Sci Reports In press
Mass Spectrometry-Based Methods for Identifying Oxidized Proteins in Disease: Advances and Challenges. Verrastro I, Pasha S, Tveen-Jensen K, Pitt AR and Spickett CM (2015) Biomolecules 5: (2):378-411
Exploring oxidative modifications of tyrosine: An update on mechanisms of formation, advances in analysis and biological consequences. Houée-Lévin C, Bobrowski K, Horakova L, Karademir B, Sch?neich C, Davies MJ, Spickett CM (2015) Free Radic Res. 49(4):347-73.
Oxidative Lipidomics Coming of Age: Advances in Analysis of Oxidized Phospholipids in Physiology and Pathology. Spickett CM, Pitt AR (2015) Antioxid Redox Signal. Mar 26. [Epub ahead of print]
Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation. Greig FH, Hutchison L, Spickett CM and Simon Kennedy S. (2015) Clin. Sci. 128(9):579-92.
Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease. Reis A, Rudnitskaya A, Chariyavilaskul P, Dhaun N, Melville V, Goddard J, Webb DJ, Pitt AR, Spickett CM. (2015) J Lipid Res. 56(2):413-22
Identification and relative quantification of tyrosine nitration in a model Peptide using two-dimensional infrared spectroscopy. Rezende Valim L, Davies JA, Tveen Jensen K, Guo R, Willison KR, Spickett CM, Pitt AR, Klug DR. (2014) J Phys Chem B. Nov 13;118(45):12855-64.
Oxidised LDL-lipids increase beta amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. Dias IH, Mistry J, Fell S, Reis A, Spickett CM, Polidori MC, Lip GY, Griffiths HR. (2014) Free Radic Biol Med. 75:48-59
HOCl-modified phosphatidylcholines induce apoptosis and redox imbalance in HUVEC-ST cells Archives of Biochemistry and Biophysics. Robaszkiewicz A, Bartosz G, Pitt AR, Thakker A, Armstrong RA, Spickett CM, Soszyński M (2014) Arch Biochem Biophys 548:1-10.
Detection of phosphatidylserine with a modified polar head group in human keratinocytes exposed to the radical generator AAPH. Maciel E, Neves BM, Santinha D, Reis A, Domingues P, Cruz MT, Pitt AR, Spickett CM, Domingues MRM (2014) Arch Biochem Biophys 548:38-45.
Post-translational Modifications and Mass Spectrometry Detection. Silva AM, Vitorino R, Domingues MR, Spickett CM, Domingues P. (2013) Free Radic Biol Med. 65: 925-41.
Joint Lipoxidation adducts with peptides and proteins: Deleterious modifications or signaling mechanisms? Domingues RM, Domingues P, Melo T, Pérez-Sala D, Reis A, Spickett CM. J Proteomics. 2013 92: 110-131.
Impairment of calcium ATPases by high glucose and potential pharmacological protection. Horakova L, Strosova MK, Spickett CM, Blaskovic D (2013) Free Radic Res. 47 Suppl 1: 81-92.
A comparison of five lipid extraction solvent systems for lipidomic studies of human LDL. Reis A, Rudnitskaya A, Blackburn GJ, Fauzi NM, Pitt AR, Spickett CM.J Lipid Res. 2013 54(7):1812-24.
Specific Lipidome Signatures in Central Nervous System from Methionine-Restricted Mice. .Jové M, Ayala V, Ramírez-Nú?ez O, Naudí A, Cabré R, Spickett CM, Portero-Otín M, Pamplona R. J Proteome Res. 2013 12(6): 2679-89.
Reporter ion-based mass spectrometry approaches for the detection of non-enzymatic protein modifications in biological samples. Tveen-Jensen K, Reis A, Mouls L, Pitt AR, Spickett CM. J Proteomics. 2013 Apr 17. doi:pii: S1874-3919(13)00180-2. 10.1016/j.jprot.2013.03.033.
The use of narrow mass-window, high-resolution extracted product ion chromatograms for the sensitive and selective identification of protein modifications. Spickett CM, Reis A, Pitt AR. Anal Chem. 2013 54(7):1812-24.
The lipid peroxidation product 4-Hydroxy-2-nonenal: advances in chemistry and analysis. Spickett C.M. (2013) Redox Biol 1(1): 145-152.
Reactions of copper macrocycles with antioxidants and HOCl: potential for biological redox sensing. Sowden RJ, Trotter KD, Dunbar L, Craig G, Erdemli O, Spickett CM, Reglinski J. (2013) Biometals 26(1) 85-96.