Rathbone,Dan
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2007 to date Senior Lecturer, Aston University1999-2007 Lecturer in Pharmaceutical Sciences, Aston University1996-99 Research Fellow, Aston University1990-95 Senior Chemist, Aston Molecules Ltd1989 Postdoctoral Fellow, Warwick University1988 Postdoctoral Fellow, Institut fur Organische Chemie und Biochemie, Bonn1984-87 PhD, University of Warwick1980-84 BA, Chemistry, St. Edmund Hall, University of Oxford近期论文
Eduard Badarau, Zhuo Wang, Dan L. Rathbone, Andrea Costanzi, Thomas Thibault, Colin E. Murdoch, Said El Alaoui, Milda Barkeviciute, Martin Griffin (2015)Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological ConditionsChemistry and Biology, 22 (10), 1347 - 1361, doi:10.1016/j.chembiol.2015.08.013Hay DL, Harris PW, Kowalczyk R, Brimble MA, Rathbone DL, Barwell J, Conner AC, Poyner DR (2014)Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation.British Journal of Pharmacology, 171, 415-426 (doi: 10.1111/bph.12464)Badarau, E., Mongeot, A., Collighan, R., Rathbone, D. & Griffin, M. (2013)Imidazolium-based warheads strongly influence activity of water-soluble peptidic transglutaminase inhibitorsEuropean Journal of Medicinal Chemistry, 66; 526-530 (DOI: 10.1016/j.ejmech.2013.05.018)Watkins, H. A., Rathbone, D. L., Barwell, J., Hay, D. L. & Poyner, D. R.(2013)Structure-activity relationships for alpha calcitonin gene-related peptideBritish Journal of Pharmacology, 170, 1308-1322 (DOI:10.1111/bph.12072)Nooshin Daneshpour, Russell Collighan, Yvonne Perrie, Peter Lambert, Dan Rathbone, Deborah Lowry, Martin Griffin (2013)Indwelling catheters and medical implants with FXIIIa inhibitors: A novel approach to the treatment of catheter and medical device-related infectionsEur. J. Pharmaceutics and Biopharmaceutics, 83: 106–113 (DOI:10.1016/j.ejpb.2012.09.005)Wang Z, Collighan RJ, Pytel K, Rathbone DL, Li X, Griffin M. (2012)Characterization of Heparin-binding Site of Tissue Transglutaminase: ITS IMPORTANCE IN CELL SURFACE TARGETING, MATRIX DEPOSITION, AND CELL SIGNALING.J. Biol. Chem. 287: 13063-13083 (doi:10.1074/jbc.M111.294819)Richard J. Bailey, Joshua W.I. Bradley, David R. Poyner, Dan L. Rathbone, Debbie L. Hay (2010)Functional characterization of two human receptor activity-modifying protein 3 variantsPeptides, 31, 579–584 (DOI:10.1016/j.peptides.2009.12.016)Tao Qi, John Simms, Richard J. Bailey, Mark Wheatley, Dan L. Rathbone, Debbie L. Hay and David R. Poyner (2010)Structure-Function Analysis of RAMP1-RAMP3 ChimerasBiochemistry, 49, 522–531 (DOI: 10.1021/bi9019093)Martin Griffin, Alexandre Mongeot, Russell Collighan, Robert E. Saint, Richard A. Jones, Ian G.C. Coutts, Daniel L. Rathbone (2008)Synthesis of potent water-soluble tissue transglutaminase inhibitorsBioorg. Med. Chem. Lett., 18, 5559–5562Cait Costello, Tarja Karpanen, Peter A. Lambert, Preena Mistry, Katy J. Parker, Daniel L. Rathbone, Jiangmeng Ren, Laura Wheeldon and Tony Worthington (2008) Thiosemicarbazones active against Clostridium difficile Bioorg. Med. Chem. Lett., 18, 1708–1711Daniel L. Rathbone, Katy J. Parker, Michael D. Coleman, Peter A. Lambert and David C. Billington (2006)Discovery of a potent phenolic N1-benzylidene-pyridinecarboxamidrazone selective against Gram-positive bacteriaBioorg. Med. Chem. Lett., 16, 879-883M.D. Coleman, R. Aerry, E. Wanogho, N.B. Khan, P.A. Lambert and D.L. Rathbone (2006) Effects of GSH and NAC on the antimicrobial efficacy of INH on M. fortuitum in vitro. J. Chemother. 18, 665-666Daniel L. Rathbone (2005) Molecularly imprinted polymers in the drug discovery processAdvanced Drug Delivery Reviews, 57, 1855-1875Daniel L. Rathbone, Aisha Ali, Polyxeni Antonaki, Sarah Cheek (2005) Towards a polymeric binding mimic for cytochrome CYP2D6Biosensors and Bioelectronics, 20, 2353-2363Daniel L. Rathbone and Ajeet Bains (2005) Tools for fluorescent molecularly imprinted polymersBiosensors and Bioelectronics, 20, 1438-1442Michael D. Coleman, Nazish Khan, Graham Welton, Peter A. Lambert, Katy J. Tims and Daniel L. Rathbone (2004)Effects of glutathione, N-acetyl-cysteine, α-lipoic acid and dihydrolipoic acid on the cytotoxicity of a 2-pyridylcarboxamidrazone antimycobacterial agent in human mononuclear leucocytes in vitroEnviron. Tox. Pharmacol., 17, 143-148Simpson, J., Forrester, R., Tisdale, M.J., Billington, D.C. and Rathbone, D.L. (2003) Effect of Catechol Derivatives on Cell Growth and Lipoxygenase ActivityBioorg. Med. Chem. Lett., 13, 2435-2439Coleman, M.D., Tims, K.J. and Rathbone, D.L., (2003)The use of computational QSAR analysis in the toxicological evaluation of a series of 2-pyridylcarboxamidrazone candidate anti-tuberculosis compounds. Environ. Tox. Pharmacol., 14, 33-42Gokhale, N.H.,? Padhye, S.B., Billington, D.C., Rathbone, D.L., Croft, S.L., Kendrick, H.D., Anson, C.E. and Powell, A.K. (2003)Synthesis and characterization of copper(II) complexes of pyridine-2-carboxamidrazones as potent antimalarial agents. Inorganica Chimica Acta, 349C, 23-29Thanh, N.T.K., Rathbone, D.L., Billington, D.C. and Hartell, N.A. (2002)Selective Recognition Of Cyclic GMP Using A Fluorescence-Based Molecularly Imprinted Polymer. Analytical Letters, 35, 2499-2509Sandbhor, U., Padhye, S., Billington, D.C.B., Rathbone, D.L., Franzblau, S., Anson, C.E. and Powell, A.K. (2002) Metal complexes of carboxamidrazone analogs as antitubercular agents 1. Synthesis, X-ray crystal-structures, spectroscopic properties and antimycobacterial activity against Mycobacterium tuberculosis H Rv 37. Journal of Inorganic Biochemistry, 90, 127-136标签: 阿斯顿大学
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- Rathbone,Dan 09-22
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