个人简历

Diploma (MSc), Ruhr-Universit?t, Bochum, Germany, 1991
Ph.D. in Biochemistry, Ruhr-Universit?t, Bochum, Germany, 1995
2015 – Current: Senior Research Fellow (Senior Lecturer), Aston Medical School, Aston University
2011 – 2015: Associate Professor, Warwick Medical School, University of Warwick
2008 – 2011: Assistant Professor, Warwick Medical School, University of Warwick
2004 – 2008: Group Leader, North West Cancer Research Fund Institute, Bangor University, UK
1998 – 2004: Senior Research Fellow, National Cancer Institute, National Institutes of Health, USA
1995 – 1998: Postdoctoral Scientist, Columbia University, New York, USA

近期论文

Zhou, L.; Lyons-Rimmer, J.; Ammoun, S.; Müller, J.; Lasonder, E.; Sharma, V.; Ercolano, E.; Hilton, D.; Taiwo, I.; Barczyk, M.; Hanemann, C.O. (2015) The Scaffold Protein KSR1, A Novel Therapeutic Target for the Treatment of Merlin-Deficient Tumors Oncogene, doi: 10.1038/onc.2015.404. [Epub ahead of print]
Hogg, E.L.; Müller, J.; Corrêa, S.A.L. (2015) “Does the MK2-Dependent Production of TNFα Regulate mGluR-Dependent Synaptic Plasticity?“ Current Neuropharmacology, doi: 10.2174/1570159X13666150624165939. [Epub ahead of print]
Eales, K.L.; Palygin, O.; O’Loughlin, T.; Rasooli-Nejad, S.; Gaestel, S.; Müller, J.; Collins, D.R.; Pankratov, Y; Corrêa, S.A.L. (2014) “The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility” Nature Communications 5:4701
Nithianandarajah-Jones, G.N.; Wilm, B.; Goldring, C.E.P.; Müller, J.; Cross, M.J. (2014) “The role of ERK5 in endothelial cell function” Biochemical Society Transactions 42, 1584-1589
Shaheen, F.; Müller, J.; Zammit, V.; Lehnert, H; Grammatopoulos, D. (2014) “Extra-nuclear Telomerase Reverse Transcriptase (TERT) Regulates Glucose Transport in Skeletal Muscle Cells” BBA - Molecular Basis of Disease 1842, 1762-1769
Nithianandarajah-Jones, G.N.; Wilm, B.; Goldring, C.E.; Müller, J.; Cross, M.J. (2012) “ERK5: structure, regulation and function” Cellular Signalling 24 (11), 2187-2196
Sarkar, D.; Shields, B.; Davies, M.L.; Müller, J.; Wakeman, J.A. (2012) “Brachyury confers cancer stem cell characteristics on colorectal cancer cells” International Journal of Cancer 130 (2), 328-337
Canal, F.; Palygin, O.; Pankratov, Y; Corrêa, S.A.L; Müller, J. (2011) “Compartmentalization of the MAPK scaffold protein KSR1 modulates synaptic plasticity in hippocampal neurons” FASEB Journal 25 (7), 2362-2372
Roberts, O.L.; Holmes, K; Müller, J.; Cross, D.A.L. Cross, M.J. (2010) “ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells” Journal of Cell Science 123, 3189-3200.
Price N.T.; Jackson, V.N.; Müller J.; Moffat, K.; Matthews, K.L.; Orton, T.; Zammit, V.A. (2010) “Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues” Journal of Biological Chemistry 285, 7857-7865
Corrêa, S.A.; Müller, J.; Collingridge, G.L.; Marrion, N.V. (2009) “Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons” Journal of Cell Science 122, 4186-4194
Roberts O.L., Holmes K., Müller J., Cross D.A., Cross M.J. (2009) “ERK5 and the regulation of endothelial cell function” Biochemical Society Transactions 37, 1254-1259
Dougherty M.K.*; Müller J.*; Ritt D.A.; Zhou M.; Zhou X.Z.; Copeland T.D.; Conrads T.P.; Veenstra T.D.; Lu K.P.; Morrison D.K. (2005) “Regulation of Raf-1 by Direct Feedback Phosphorylation” Molecular Cell 17, 215-224 *These authors contributed equally to this work
Müller, J.; Ritt, D.A.; Copeland, T.D.; Morrison, D.K. (2003) “Functional Analysis of C-TAK1 Substrate Binding and Identification of PKP2 as a New C-TAK1 Substrate” EMBO Journal 22, 4431-4442
Müller, J.; Morrison, D.K. (2002) “Assay of Raf-1 activity” Methods in Enzymology 345, 490-498
Müller, J.; Ory, S.; Copeland, T.; Piwnica-Worms, H.; Morrison, D.K. (2001) “C-TAK1 Regulates Ras Signalling by Phosphorylating the MAPK Scaffold, KSR1” Molecular Cell 8, 983-993
Müller, J.*; Cacace, A.M.*; Lyons, W.E.; McGill, C.B.; Morrison, D.K. (2000) “Identification of B-KSR1, a Novel Brain-Specific Isoform of KSR1 that Functions in Neuronal Signalling” Molecular and Cellular Biology, 20, 5529-5539 *These authors contributed equally to this work