近期论文

Qi, X., D.R. Rand, J.D. Podlevsky, Y. Li, A. Mosig, P.F. Stadler and J.J.-L. Chen (2015) Prevalent and distinct spliceosomal 3'-end processing mechanisms for fungal telomerase RNA. Nature Communications 6, 6105r
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Stanley, S.E., J.J.-L. Chen, J.D. Podlevsky, J.K. Alder, N.N. Hansel, R. Mathias, X. Qi, N.N. Rafaels, R.A. Wise, E.K. Silverman, K.C. Barnes and M. Armanios (2014) Telomerase mutations in smokers with emphysema. The Journal of Clinical Investigation 125(2), 563-70r
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Brown, A.F., J.D. Podlevsky, X. Qi, Y. Chen, M. Xie, and J.J.-L. Chen (2014) A self-regulating template in human telomerase. Proc. Natl. Acad. Sci. U.S.A. 111(31): 11311-11316r
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Huang, J., A.F. Brown, J. Wu, J. Xue, C.J. Bley, D.P. Rand, L. Wu, R. Zhang, J.J.-L. Chen* and M. Lei* (2014) Structural basis for protein-RNA recognition in telomerase. Nature Structural and Molecular Biology 21:507-512r
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Brown, A.F., J.D. Podlevsky and J.J.-L. Chen (2014) Telomerase: A eukaryotic DNA polymerase specialized in telomeric repeat synthesis. In Nucleic Acid Polymerases-1st edition, M. Trakselis and K. Murakami, eds., Springer Press. p.215-236.r
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Li, Y., J.D. Podlevsky, M. Marz, X. Qi, S. Hoffmann, P.F. Stadler and J.J.-L. Chen (2013) Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach. RNA 19(6): 852-860r
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Gramatges, M.M., X. Qi, G.S. Sasa, J.J.-L. Chen and A.A. Bertuch (2013) A homozygous telomerase T motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome. Blood 121(18):3586-3593r
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Qi, X., Y. Li, S. Honda, S. Hoffmann, M. Marz. A. Mosig, J.D. Podlevsky, P.F. Stadler, E. Selker and J.J.-L. Chen (2012) The common ancestral core of vertebrate and fungal telomerase RNAs. Nucleic Acids Research 41(1): 450-462r
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Qi, X., M. Xie, A.F. Brown, C.J. Bley, J.D. Podlevsky and J.J.-L. Chen (2012) RNA/DNA hybrid binding affinity determines telomerase template translocation efficiency. EMBO J. 31: 150-161r
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Tzfati, Y. and J.J.-L. Chen (2012) Telomerase RNA: Structure, function, and molecular mechanisms. In Telomerases: Chemistry, Biology and Clinical Applications-1st edition, N. Lue and C. Autexier, eds., John Wiley & Sons, Inc. p.23-51.r
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Podlevsky, J.D. and J.J.-L. Chen (2012) It all comes together at the ends: Structure, function, and biogenesis of telomerase. Mutation Research 730: 3-11r
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Bley, C.J., X. Qi, D.P. Rand, C.R. Borges, R.W. Nelson and J.J.-L. Chen (2011) RNA-protein binding interface in the telomerase ribonucleoprotein. Proc. Natl. Acad. Sci. U.S.A. 108(51): 20333-20338r
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Parry, E.M., J.K. Alder, X. Qi, J.J.-L. Chen and M.Y. Armanios (2011) Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood 117(21): 5607-5611r
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Alder, J.K., J.D. Cogan, A.F. Brown, C.J. Anderson, W.E. Lawson, P.M. Lansdorp, J.A. Phillips 3rd, J.E. Loyd, J.J.-L. Chen, and M.Y. Armanios (2011) Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PLoS Genetics 7(3): e1001352r
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Lawrence, R.M., B. Varco-Merth, C.J. Bley, J.J.-L. Chen, and P. Fromme (2011) Recombinant production and purification of the subunit c of chloroplast ATP synthase. Protein Expression and Purification 76: 15-24.r
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Xie, M., J.D. Podlevsky, X. Qi, C.J. Bley and J.J.-L. Chen (2010) A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity. Nucleic Acids Research 38: 1982-1996r
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Stadler,P.F., J.J.-L. Chen, J. Hackermuller, S. Hoffmann, P. Khaitovich, A. Kretzschmar, A. Mosig, S.J. Prohaska, X. Qi, K. Schutt and K. Ullmann (2009) Evolution of vault RNAs. Molecular Biology and Evolution 26: 1975-1991.r
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Alder, J.K., J.J.-L Chen, L. Lancaster, S. Danoff, S.C. Su, M. Prince, I. Vulto, M. Xie, X. Qi, R.M. Tuder, J.A. Phillips, P.M. Lansdorp, J.E. Loyd and M.Y. Armanios (2008) Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc. Natl. Acad. Sci. U.S.A. 105: 13051-13056r
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Ye, Y., W. Wen, Y. Xiang, X. Qi, J.T. LaBelle, J.J.-L. Chen and J. Wang (2008) Direct electrochemical monitoring of RNase activity. Electroanalysis 20: 919-922.r
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Xie, M., A. Mosig, X. Qi, Y. Li, P.F. Stadler and J.J.-L. Chen (2008) Structure and function of the smallest vertebrate telomerase RNA from teleost fish. Journal of Biological Chemistry 283: 2049-2059
Podlevsky, J.D., C.J. Bley, R.V. Omana, X. Qi and J.J.-L. Chen (2008) The telomerase database. Nucleic Acids Research 36: D339-D343