个人简历

张建民，2003年毕业于中国协和医科大学基础医学院免疫学系，获免疫学博士学位。 2004年2月到耶鲁大学生物免疫生物学系做博士后，2005年8月转到约翰霍普金斯大学医学院神经病学系做博士后，2009 - 2013年约翰霍普金斯大学医学院神经病学系任讲师、助理教授。现任中国医学科学院/北京协和医学院免疫学系“协和学者”特聘教授、博士生导师。

研究领域

""其主要从事神经性疾病的免疫调控研究，主要研究成果发表在Cell, PNAS等知名杂志上。 """"

近期论文

1) Jia Yang, Qi Yang, Menghua Cai, Chao Li, Fei Gao, Huaishan Wang, Dongdong Wang, Yi Fu, Yu Zhou, Hui Chen, Yu Hu, Xuan Zhang, Wei He*, Jianmin Zhang*. ATPase Thorase Regulates Mitochondrial Quality Control and Pathogenesis of Neurodegenerative Diseases. (Under revision on Neuron)\r
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2) Huaishan Wang, Fei Gao, Jia Yang, Yi Fu, Yingchao Xue, Qi Yang, Menghua Cai, Xue Zhang, Yu Zhou, Kangle Zhai, Yu Hu, Hui Chen, Fang Liu, Yi Xu, Chao Ma, Wei He* and Jianmin Zhang*. TSPO/PBR Knockout Promotes Amyloid Pathology and Neuroinflammation by Affecting Microglia Phagocytosis. (Under revision on Neurobiology of ageing)\r
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3) Yi Fu, Dongdong Wang, Huaishan Wang, Junwen Zhang, Hui Chen, Yu Hu, Xuan Zhang, Mingyao Ying, Wei He*, Jianmin Zhang*. TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis and a growth-promoting metabolic shift towards glycolysis in glioblastoma. Neuro Oncol. 2019 Sep 29. pii: noz183. doi: 10.1093/neuonc/noz183.\r
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4) Yuxia Li, Xinfeng Wang, Da Teng, Hui Chen, Maoshui Wang, Junjing Wang, Jianmin Zhang*, Wei He.Identification of the Ligands of TCRγδ by Screening the Immune Repertoire of γδT Cells from Patients with Tuberculosis. Front. Immunol., 24 September 2019 https://doi.org/10.3389/fimmu.2019.02282\r
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5) Menghua Cai, Yan Zhu, Zinan Li, Yu Zhou, Yu Hu, Hui Chen, Yun Liu *, Wei He * and Jianmin Zhang*. Profiling the Gene Expression and DNA Methylation in the Mouse Brain after Ischemic Preconditioning. Neuroscience. 406 (2019) 249–261\r
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6) Fei Gao, Jianmin Zhang *. Mitochondrial quality control and neurodegenerative diseases. Neuronal Signalling. (2018) https://doi.org/10.1042/NS20180062\r
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7) Yingchao Xue, Xiping Zhan, Shisheng Sun, Senthilkumar S. Karuppagounder, Shuli Xia, Valina L. Dawson, Ted M. Dawson, John Laterra, Jianmin Zhang* and Mingyao Ying*. Synthetic mRNAs drive highly efficient iPSC cell differentiation into dopaminergic neurons. Stem Cell Translational Medicine. 2018 Nov 1. doi: 10.1002/sctm.18-0036\r
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8) Peng Dong, Xiangwu Ju, Yiwu Yan, Siya Zhang, Menghua Cai, Huaishan Wang, Hui Chen, Yu Hu, Lianxian Cui, Jianmin Zhang*, Wei He*. γδ T cells provide protective function in highly pathogenic avian H5N1 influenza A virus infection. 2018 Dec 4;9:2812. doi: 10.3389/fimmu.2018.02812. eCollection 2018..\r
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9) Xue Zhang, Fei Gao, Dongdong Wang, Chao Li, Yi Fu, Wei He*, Jianmin Zhang*. Tau pathology in Parkinson’s disease. Front. Neurol., October 2, 2018; https://doi.org/10.3389/fneur.2018.00809\r
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10) Jianmin Zhang, Jia Yang, Huaishan Wang, Omar Sherbini, Matthew J. Keuss, George K. E. Umanah, Emily Ling-Lin Pai , Zhikai Chi, Kaisa M. A. Paldanius, Wei He, Hong Wang, Shaida A. Andrabi, Ted M. Dawson, and Valina L. Dawson The AAA + ATPase Thorase is neuroprotective against ischemic injury. J Cereb Blood Flow Metab. 2018 Jan 1:271678X18769770. doi: 10.1177/0271678X18769770\r
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11) Zinan Li, Siya Zhang, Ying Wan, Weiqing Wang, Yuli Zhu, Zhen Li, Yu Hu, Huaishan Wang, Hui Chen, Lianxian Cui, Xuan Zhang, Jianmin Zhang*, Wei He*. miR-146a Regulates the Positive Selection During T Cell Development. Front Immunol.2018 Jan 23;8:2006. doi: 10.3389/fimmu.2017.02006\r
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12) Yuli Zhu, Siya Zhang, Zinan Li, Huaishan Wang, Zhen Li, Yu Hu, Hui Chen, Xuan Zhang, Lianxian Cui, Denian Ba, Jianmin Zhang*, Wei He*. MiR-125b-5p and miR-99a-5p regulate the activation and cytotoxicity of gd T cells. Cell Mol Immunol.2018 Feb 12. doi: 10.1038/cmi.2017.164\r
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13) Hui Chen, Mingjin Zou, Da Teng, Yu Hu, Jianmin Zhang*, Wei He1*. Profiling the pattern of the human T cell receptor γδ complementary determinant region 3 repertoire in patients with lung carcinoma. Cell Mol Immunol. 2018 Feb 5. doi: 10.1038/cmi.2017.157\r
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14) Fei Gao, Jia Yang, Chao Li, Huaishan Wang, Wei He*, Jianmin Zhang*. Mitophagy in Parkinson Disease: Pathogenic Roles and Therapeutic Implications. Front. Neurol., 2017; doi.org/10.3389/fneur.2017.00527\r
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15) Wen-Xiu Mo, Shan-Shan Yin, Hua Chen, Chen Zhou, Jia-Xin Zhou, Li-Dan Zhao, Yun-Yun Fei, Hua-Xia Yang, Jing-Bo Gou, Yu-Jia Mao, Lin-Fang Huang, Wen-Jie Zheng, Wen Zhang, Jian-Min Zhang, Wei He*, Xuan Zhang*. Chemotaxis of Vδ2 T cells to the joints contributes to the pathogenesis of Rheumatoid Arthritis. Ann Rheum Dis. 2017 Dec;76(12):2075-2084. doi: 10.1136/annrheumdis-2016-211069\r
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16) Chen H, Zou M, Teng D, Zhang J*, He W. Characterization of the diversity of T cell receptor γδ complementary determinant region 3 in human peripheral blood by Immune Repertoire Sequencing. J Immunol Methods. 2017 Jan 31. pii: S0022-1759(16)30291-5. doi: 10.1016/j.jim.2017.01.009.\r
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17) Wang H, Zhai K, Xue Y, Yang J, Yang Q, Fu Y, Hu Y, Liu F, Wang W, Cui L, Chen H, Zhang J*, He W*. Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile. PLoS One. 2016 Dec 1;11(12):e0167307. doi: 10.1371/journal.pone.0167307\r
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18) Jianmin Zhang, Huaishan Wang, Omar Sherbini, Emily Ling-lin Pai, Sung-Ung Kang, Ji-Sun Kwon, Jia Yang, Wei He, Hong Wang, Stephen M. Eacker, Zhikai Chi, Xiaobo Mao, Jinchong Xu, Haisong Jiang, Shaida A. Andrabi, Ted M. Dawson, Valina L. Dawson. High Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death. eNEURO. 2016 Oct 7. DOI: 10.1523/ENEURO.0185-16.2016\r
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6. 课题组近5年专利\r
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1) γδT淋巴细胞中δ1链互补决定域3的优势序列及其TCR受体转染细胞与应用。授权公告日：2014.07.09；专利号：ZL 2011 1 0126369.3。\r
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2) 基因修饰CDR3δ移植型γδT淋巴细胞及其抑癌用途。授权公告日：2014.08.13；专利号：ZL 2010 1 0518490.6。\r
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3) 抗人γδTCR单克隆抗体的重组单链抗体G5-4ScFv及其编码基因与应用。专利申请日：2011.11.30；授权公告日：2017.04.12。专利号/申请号：201110139150.3。\r
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4) 肿瘤结合特异性gdTCR基因修饰的αβT细胞及其抑癌用途。专利申请日：2015.11.26；授权公告日：2018.10.09；专利号/申请号：201510846740.1。\r
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5) 一种检测过敏原的新型蛋白质芯片。专利申请日：2017.04.28;申请号 201710293500.2. （正在审理中）