个人简历

王晓月，2010年博士毕业于约翰霍普金斯大学医学院生物化学系。2010年到2013年在芝加哥大学基因组学和系统生物学研究所进行博士后研究。2014年被聘为“协和学者”特聘教授。现任基础医学研究所生物信息中心主任，课题组隶属于医学分子生物学国家重点实验室。\r
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课题组研究方向为功能基因组学和生物信息学，主要致力于开发新的方法高通量研究肿瘤中基因变异的功能，为癌症风险预测和精确诊疗提供新的依据。一方面通过整合已有的大量基因组学和临床数据，挖掘与癌症风险、癌症治疗相关的突变位点；另一方面开发并使用高通量实验方法检测肿瘤中变异的功能，研究突变与基因间、基因与基因间以及基因与药物间的相互作用，寻找可能的药物靶点和治疗方法。

研究领域

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近期论文

课题组近期部分发表论文：\r
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#co-first authors, *co-corresponding authors\r
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[1] Changcai Huang#, Guangyu Li#, Jiayu Wu, Junbo Liang*, Xiaoyue Wang*. Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. Genome Biology, 2021, 22:80\r
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[2] Hongchao Liu, Huihui Yin, Guangyu Li, Junling Li*, Xiaoyue Wang*. Aperture: Alignment-free detection of structural variations and viral integrations in circulating tumor DNA. Briefings in Bioinformatics, 2021, (accepted).\r
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[3] Junbo Liang#, Hong Zhao#, Bill H. Diplas#, Song Liu#, Jianmei Liu, Dingding Wang, Yan Lu, Qing Zhu, Jiayu Wu, Wenjia Wang, Hai Yan, Yi-Xin Zeng, Xiaoyue Wang*, Yuchen Jiao*. Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX -Mutant Cancers to WEE1 Inhibition. Cancer research, 2020, 80(3):510-523.\r
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[4] Junbo Liang#, Hongchao Liu#, Guangyu Li, Jun Qian, Ran Gao, Yanchi Zhou, Xiaoyue Wang*. Global changes in chromatin accessibility and transcription following ATRX inactivation in human cancer cells. FEBS Letters, 2020, 594(1).\r
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[5] Bing Zhao#*, Chao Ni#, Ran Gao#, Yuyan Wang, Li Yang, Jinsong Wei, Ting Lv, Jianqing Liang, Qisheng Zhang, Wei Xu, Youhua Xie, Xiaoyue Wang, Zhenghong Yuan, Junbo Liang*, Rong Zhang*, and Xinhua Lin*. Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein & Cell, 2020.\r
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[6] Yinghao Cao, Xiaoyue Wang*, Gongxin Peng*. SCSA: A cell type annotation tool for single-cell RNA-seq Data. Frontiers in Genetics. 2020.11:490.\r
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[7] Song Liu#, Yuwen Liu#, Qin Zhang, Jiayu Wu, Junbo Liang, Shan Yu, Gong-Hong Wei, Kevin P. White*, Xiaoyue Wang*. Systematic identification of regulatory variants associated with cancer risk. Genome Biology, 2017, 18(1):194.\r
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[8] Xiaoyue Wang#, Audrey Q. Fu#, Megan E. McNerney, Kevin P. White*. Widespread genetic epistasis among cancer genes. Nature communications, 2014, 5:4828.