个人简历

余佳，男，1978年生，研究员，博士生导师，北京协和医学院长聘教授（首批）、RNA与干细胞生物学课题组组长，中国医学科学院RNA与造血调控研究重点实验室主任，医学分子生物学国家重点实验室PI。获得国家杰出青年科学基金(2017，生命科学部)，长江学者奖励计划(2017)，百千万人才工程国家级人选（2019），国务院政府特殊津贴（2020）等人才项目支持。担任科技部十三五“发育编程及其代谢调节”重点研发专项首席科学家，十四五“发育编程及其代谢调节”重点研发专项总体专家组、指南编写组成员。2006年7月毕业于中国医学科学院/北京协和医学院基础医学研究所生化与分子生物学系，理学博士。2006-2007年在美国伊利诺伊大学芝加哥分校工作(Post-doc)。2007-2009年在美国西北大学Feinberg医学院工作(Post-doc)。2009年10月回国加入中国医学科学院基础医学研究所生化系及医学分子生物学国家重点实验室。作为负责人承担国家自然科学基金委重大研究计划、重点项目及面上项目等；作为负责人承担科技部国家重点研发计划、973子课题及国家重大研究计划。余佳博士同时担任中国医学科学院-以色列Weizmann研究所联合实验室PI，中国医学科学院“医学与健康科技创新工程”创新团队项目首席科学家，人血细胞分子图谱（ABC）研究联盟首批倡议及参加成员。余佳实验室主要兴趣集中在造血调控、干细胞命运及转化医学，综合运用多种组学及计算生物学方法，干细胞培养及基因操纵等体外实验技术，干细胞移植、基因敲除小鼠及谱系示踪等体内技术，结合生化与分子生物学手段，研究RNA、互作蛋白质及相关遗传信息传递过程在干细胞或疾病中的功能和调控机理。在组织器官发育与疾病的细胞图谱、非编码RNA生成与加工新机理、干细胞命运调控新机制等方面取得突出成果，相关研究成果作为通讯作者（含共同）在Cell Stem Cell、Developmental Cell、EMBO Journal（2015，2021）、Cell Research、Genome Research、Blood、Nature Communications（2017，2019）、Genome Biology 、Cancer Research（2010，2015，2020）、Nucleic Acids Research（2013，2014，2017，2020）、Autophagy、Oncogene、MCB等国际主流学术期刊上发表SCI论文30余篇，被引用3000余次。获教育部自然科学二等奖（2018）。

研究领域

""RNA与干细胞生物学""""

近期论文

1.Yanni Ma*, Zhongyang Chen, Jia Yu*. Pseudogenes and their potential functions in hematopoiesis. Experimental Hematology. 2021 Sep 10:S0301-472X(21)00292-7. doi: 10.1016/j.exphem.2021.09.001.\r
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2.Rue Ren†, Yue Huo†, Weiqian Li†, Manman He, Siqi Liu, Jiabing Yang, Hongmei Zhao, Lingjie Xu, Yuehong Guo, Yanmin Si, Hualu Zhao, Shuan Rao, Jing Wang, Yanni Ma, Xiaoshuang Wang*, Jia Yu*, Fang Wang*. Nuclear fractionation reveals chromatin-enriched RNA-binding proteins and transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biology. 2021 Oct 14;22(1):290. doi: 10.1186/s13059-021-02508-7.\r
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3.Fengjiao Wang†, Jiahuan He†, Siqi Liu†, Ai Gao, Liu Yang, Guohuan Sun, Wanqiu Ding, Chuanyun Li, Fanglin Gou, Manman He, Fang Wang, Xiaoshuang Wang, Xiangnan Zhao, Ping Zhu, Shao Hao, Yanni Ma*, Hui Cheng*, Jia Yu*, Tao Cheng*. Comprehensive RNA editome reveals edited Azin1 as a novel DDX1 partner to facilitate hematopoietic stem cell differentiation. Blood. 2021 August 13. Advanced published online. doi:10.1182/blood.2021011314.\r
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4.Jingnan Pi†, Wen Wang†, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang*, Jia Yu*. YTHDF1 promotes gastric carcinogenesis through controlling the translation of FZD7. Cancer Research. 2021 May 15. 81(10): 2651-2665. doi: 10.1158/0008-5472.CAN-20-0066.\r
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5.Xue Wang†, Changyun Ping†, Puwen Tan†, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*, Jia Yu*, Yanni Ma*, Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. The EMBO Journal. 2021 Feb 15. 40(4):e104729. doi: 10.15252/embj.2020104729. \r
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6.Yanni Ma†*, Siqi Liu†, Jie Gao†, Chunyan Chen†, Xin Zhang†, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Fanqi Zhou, Yi Shao, Qian Liu, Jiayue Xu, Li Cheng, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Yanmin Si, Hualu Zhao, Haipeng Li, Graham L Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi*, Yong E Zhang*, Jia Yu*. Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia. Developmental Cell. 2021 Jan 12. 56(4):478–493.e11. doi: 10.1016/j.devcel.2020.12.019.\r
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7.Kai Li†, Jiayue Xu†, Yanyun Luo†, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26. doi: 10.1101/gr.264333.120.\r
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8.Tao Liu†, Qinglv Wei†, Jing Jin†, Qingya Luo, Yi Liu, Yu Yang, Chunming Cheng, Lanfang Li, Jingnan Pi, Yanmin Si, Hualiang Xiao, Li Li, Shuan Rao, Fang Wang, Jianhua Yu, Jia Yu*, Dongling Zou*, Ping Yi*. The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Nucleic Acids Research. 2020 Apr 17. 48(7):3816-3831. doi: 10.1093/nar/gkaa048.\r
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9.Xinjie Bao†, Gengchao Wang†, Shan Yu†, Jian Sun, Hualu Zhao, Yanni Ma, Fang Wang, Xiaoshuang Wang*, Renzhi Wang*, Jia Yu*. Transcriptomic analysis reveals a tumor subtype-mRNA classifier for invasive non-functioning pituitary adenoma diagnostics. Theranostics. 2020 Jan 1. 11(1):132-146. doi: 10.7150/thno.47525.\r
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10.Jie Zhou†, Jiayue Xu†, Lingling Zhang†, Siqi Liu†, Yanni Ma†, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, and Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2): 285-298. doi: 10.1016/j.stem.2018.11.023.\r
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11.Dong L†, Zhang Z†, Xu J, Wang F, Ma Y, Li F, Shen C, Liu Z, Zhang J, Liu C*, Yi P*, Yu J*. Consistency analysis of microRNA-arm expression reveals microRNA-369-5p/3p as tumor suppressors in gastric cancer. Molecular Oncology. 2019 Jul. 13(7):1605-1620. doi: 10.1002/1878-0261.12527.\r
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12.Zhengyi Zhang†, Jingnan Pi†, Dongling Zou†, Xiaoshuang Wang†, Jiayue Xu†, Shan Yu, Ting Zhang, Feng Li, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance partially from targets-mediated decay promotes gastric cancer progression. Nature Communications. 2019 Sep 27. 10(1):4397. doi: 10.1038/s41467-019-12292-5.\r
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13.Lintao Zhao, Ran He, Haixia Long, Bo Guo, Qingzhu Jia, Diyuan Qin, Si-Qi Liu, Zhongyu Wang, Tong Xiang, Jue Zhang, Yulong Tan, Jiani Huang, Junying Chen, Fang Wang, Minglu Xiao, Jianbao Gao, Xinxin Yang, Hao Zeng, Xinxin Wang, Chunyan Hu, Peter B. Alexander, Alistair L. J. Symonds, Jia Yu, Yisong Wan, Qi-Jing Li, Lilin Ye, Bo Zhu. Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. Nature Medicine. 2018 Oct. 24(10):1536–1544. doi: 10.1038/s41591-018-0205-5.\r
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14.Weiqian Li, Yue Ren, Yanmin Si, Fang Wang*, Jia Yu*. Long non-coding RNAs in hematopoietic regulation. Cell Regen (London). 2018 Oct 11. 7(2):27-32. doi: 10.1016/j.cr.2018.08.001. (Review)\r
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15.Hongmei Zhao†, Xiaoshuang Wang†, Ping Yi†, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*, Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature Communications. 2017 Nov 10. 8(1):1428. doi: 10.1038/s41467-017-01425-3.\r
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16.Fang Wang†, Wei Song†, Hongmei Zhao†, Yanni Ma, Yuxia Li, Di Zhai, JingnanPi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu*. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research. 2017 Mar. 27(3):416-439. doi: 10.1038/cr.2017.26.\r
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17.Yongfei Hu, Yan Huang, Ying Yi, Hongwei Wang, Bing Liu*, Jia Yu*, Dong Wang*. Single-cell RNA sequencing highlights transcription activity of autophagy-related genes during hematopoietic stem cell formation in mouse embryos. Autophagy. 2017 Apr 3. 13(4):770-771. doi: 10.1080/15548627.2016.1278093.\r
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18.Ying Yi, Yue Zhao, Chunhua Li, Lin Zhang, Huiying Huang, Yana Li, LanlanLiu, Ping Hou, Tianyu Cui, Puwen Tan, Yongfei Hu, Ting Zhang, Yan Huang, Xiaobo Li*, Jia Yu*, Dong Wang*. RAID v2.0: an updated resource of RNA-associated interactions across organisms. Nucleic Acids Research. 2017 Jan 4. 45(D1):D115-D118. doi: 10.1093/nar/gkw1052.\r
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19.Rui Su†, Lei Dong†, Dongling Zou, Hongmei Zhao, Yue Ren, Feng Li, Ping Yi, Lanfang Li, Yong Zhu, Yanni Ma, Jing Wang, Fang Wang*, Jia Yu*. MicroRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. Oncogene. 2016 Nov 17. 35(46):6001-6014. doi: 10.1038/onc.2016.127.\r
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20.Wang W, Zhao L, Wei X, Wang L, Liu S, Yang Y, Wang F, Sun G, Zhang J, Ma Y*, Zhao Y*, and Yu J*. MicroRNA-320a promotes 5-FU resistance in human pancreatic cancer cells. Scientific Reports. 2016 Jan 9. 6:27641. doi: 10.1038/srep27641.\r
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21.Yanni Ma†, Nan Yao†, Guang Liu†, Lei Dong, Fang Wang, Bin Wang, He Dong, Xueju Wei, Meili Zhang, Shaowei Ji, Yufang Liu, Junwu Zhang, Yangming Wang, Yue Huang*, Jia Yu*. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cell. The EMBO Journal. 2015 Feb 3. 34(3):361–378. doi: 10.15252/embj.201489957.\r
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22.Yuxuan Wang†, Changzheng Liu†, Min Luo†, Zhengyi Zhang†, Jianan Gong, Jingjing Li, Lei Dong, Haishuang Lin, Yanni Ma, Fang Wang, Yi Wang, Jie Chen, Junwu Zhang, Hongyan Jia, Yan Kong, Jia Yu*. Chemotherapeutic drugs induced miR-29s-cateninδsignaling suppresses metastasis in gastric cancer. Cancer Research. 2015 April 1. 75(7):1332-44. doi: 10.1158/0008-5472.\r
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23.Fang Wang†, Yong Zhu†, Lihua Guo†, Lei Dong, Huiwen Liu, Haixin Yin, Zhongzu Zhang, Y Li, Changzheng Liu, Yanni Ma, Wei Song, Aibin He, Qiang Wang, Linfang Wang, Junwu Zhang, Jianxiong Li, Jia Yu*. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Research. 2014 Jan. 42(1):442-457. doi: 10.1093/nar/gkt848.\r
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24.Gong J, Li J, Wang Y, Liu C, Jia H, Jiang C, Wang Y, Luo M, Zhao H, Dong L, Song W, Wang F, Wang W, Zhang J*, and Yu J*. Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer. Carcinogenesis. 2014. 35(2):497-506. doi: 10.1093/carcin/bgt337. (Cited by 37)\r
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25.Yong Zhu†, Dongsheng Wang†, Fang Wang†, Tingting Li, Lei Dong, Huiwen Liu, Yanni Ma, Fengbing Jiang, Haixin Yin, Wenting Yan, Ming Luo, Z Tang, Guoyuan Zhang, Qiang Wang, Junwu Zhang, Jingguo Zhou, Jia Yu*. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Research. 2013 Apr. 41(7):4129-43. doi: 10.1093/nar/gkt093.\r
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26.Yanni Ma†, Bin Wang†, Fengbing Jiang†, Dongsheng Wang†, Huiwen Liu, Yunmeng Yan, He Dong, Fang Wang, Bei Gong, Yong Zhu, Lei Dong, Haixin Yin, Zhongzu Zhang, Hualu Zhao, Zhikui Wu, Junwu Zhang, Jingguo Zhou, Jia Yu, Jia Yu*. A Feedback Loop Consisting of MicroRNA 23a/27a and the Beta-Like Globin Suppressors KLF3 and SP1 Regulates Globin Gene Expression. Molecular and Cellular Biology. 2013 Oct. 33(20):3994-4007. doi: 10.1128/MCB.00623-13.\r
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27.Jia Yu*, Fang Wang. Recent progress in microRNA study: Benefits from technique advance. SCIENCE CHINA Life Sciences. 2012 July. 55(7):649-650. doi: 10.1007/s11427-012-4342-7. (Invited comment)\r
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28.Xiaoshuang Wang†, Jianan Gong†, Jia Yu, Fang Wang, Xinhua Zhang, Xiaolin Yin, Zhenqing Tan, Zimian Luo, Guihua Yang, Chao Shen, Junwu Zhang. MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood. 2012 May 24. 119(21):4992-5004. doi: 10.1182/blood-2011-10-385716. (Cited by 90)\r
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29.Fang Wang, Jia Yu, Guihua Yang, Xiaoshuang Wang, Junwu Zhang. Regulation of erythroid differentiation by miR-376a and its targets. Cell Research. 2011 Aug. 21(8):1196-209. doi: 10.1038/cr.2011.79.\r
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30.Shuangni Yu, Zhaohui Lu, Changzheng Liu, Yunxiao Meng, Yihui Ma, Wugan Zhao, Jianping Liu, Jia Yu*, Jie Chen *. MiRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer Research. 2010 Jul 15. 70(14):6015-25. doi: 10.1158/0008-5472.CAN-09-4531. (Cited by 271)\r
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31.Changzheng Liu†, Jia Yu†, Shuangni Yu, Robert M.Lavker, Lei Cai, Wei Liu, Kegong Yang, Xiaodong He, Songsen Chen. MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. Journal of Hepatology. 2010 Jul. 53(1):98-107. doi: 10.1016/j.jhep.2010.02.021. (Cover story, Cited by 182) \r
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32.Jia Yu†, Han Peng†, Qing Ruan, Anees Fatima, Spiro Getsios, and Robert M. Lavker. MicroRNA-205 promotes keratinocyte migration via the lipidphosphatase SHIP2. The FASEB Journal. 2010 Oct. 24(10):3950-9. doi: 10.1016/j.jhep.2010.02.021. (Cited by 118) \r
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33.Robert M. Lavker, Jia Yu and David G Ryan. The Tiny World of MicroRNAsin the Cross Hairs of the Mammalian Eye. Human Genomics. 2009 Jul. 3(4):332-348. doi: 10.1186/1479-7364-3-4-332. (Review)\r
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34.Jia Yu†, David G. Ryan†, Spiro Getsios, Michelle Oliveira-Fernandes, Anees Fatima, and Robert M. Lavker. MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proceedings of the National Academy of Sciences of the USA. 2008 Dec 9. 105(49):19300-5. doi: 10.1073/pnas.0803992105. (Cited by 239)
现担任北京市生化协会理事；中国生理学会血液生理专业委员会理事，血液表观遗传学组组长；中华预防医学会生物信息学专业委员会常委；抗癌协会血液肿瘤分会青委会副主任；担任Blood, Nature Communications, Nucleic Acids Research, Oncogene, Cancer Research, MCB, JBC等杂志特邀审稿人。