个人简历

日本东京农工大学获得博士学位，美国宾西法尼亚州立大学博士后研究员。北京大学生命科学学院教授，博士生导师，学位委员会委员。担任国家自然科学基金医学科学领域学科评审组成员，北京市自然科学基金生物学科组会议评审专家。中国生物化学与分子生物学会酶学专业委员会委员、常务委员，中国生物物理学会女科学家分会理事。北京市生物化学与分子生物学学会副理事长。 研究组主要利用生化分子生物学、细胞生物学、免疫学和结构生物学等技术方法，鉴定新的调控肿瘤细胞生长、炎症和固有免疫性疾病的蛋白，包括影响肿瘤转移和耐药的外泌体蛋白，研究这些蛋白发挥作用的信号通路和分子机制。探讨泛素化、类泛素化和磷酸化等蛋白质翻译后修饰在DNA 损伤应答、炎症、肿瘤发生发展中的调控作用及机制，明确蛋白质功能的失调与炎症、肿瘤等重大疾病的发生和发展的关系。 先后主持、承担了20余项国家自然科学基金重点项目、面上项目，国际合作ICGEB课题，教育部博士点基金和优先发展基金、国家“重大科学研究计划”课题，科技部863课题、973课题等多项课题的研究。教育经历: 1994 - 1998 , 理学博士 , 生化与分子生物学 , 东京农工大学 工作经历: 2008年6月 - 至今 , 教授 , 北京大学 生命科学学院 2002年5月 - 2008年5月 , 副教授 , 北京大学 生命科学学院 1998年4月 - 2002年4月, 博士后研究员 , 美国 宾夕法尼亚州大学

研究领域

1. 炎症和肿瘤发生发展重要调控蛋白的鉴定和作用机制。2. 蛋白质的泛素化、类泛素化、磷酸化等修饰对NF-κB、p53等信号通路以及DNA损伤应答的调节作用及其机制。3. 流感、乙肝等病毒重要蛋白的结构和功能研究。

近期论文

1.Yang CZ, Zang WC, Tang ZF, Ji YP, Xu RD, Yang YF, Luo AP, Hu B, Zhang ZM, Liu ZH, Zheng XF*. (2018) A20 regulates the DNA damage response and mediates tumor cell resistance to DNA damaging therapy. Cancer Research. 78, 1069-1082. Doi: 10.1158/0008-5472.CAN-17-2143. 2.Guan JH, Yu SY, Zheng XF*. (2017) NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage. Protein Cell. DOI 10.1007/s13238-017-0455-x. 3.Ji YP, Yang CZ, Tang ZF, Yang YF, Tian YL, Yao HW, Zhu X, Zhang ZM, Ji JF, Zheng XF*. (2017) Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells in a glycolysis-dependent manner by facilitating LDHA phosphorylation. Nature Communications. 8:15308. Doi.10.1038/ncomms15308. 4. Dong XD, GuanJH, ZhengCF, Zheng XF*. (2017) Herpes simplex virus-1 UL36USP suppresses translesion synthesis pathway by deubiquitinating PCNA. J Biol Chem. Accepted. 5. Bai DM, Zheng XF*. (2017) PML-RARA mutations confer varying arsenic trioxide resistance. Protein & Cell. 8(4):296–301. DOI: 10.1007/s13238-016-0356-4. 6. Bai DM, Zhang J, Li T, Hang R, Liu Y, TianY, Huang D, Qu L, Cao XF, Ji J-F, Zheng XF*. (2016) The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumor growth. Nature Communications.7: 12310. 7. Severin C,, Rocha de Moura T, Liu Y, Li K, Zheng XF*, Luo M*. (2016) The cap binding site of influenza virus protein PB2 as a drug target. Acta Cryst. D72, 245-253. 8. Qu LL, Ji YP, Zhu X, Zheng XF*. (2015) hCINAP Negatively Regulates NF-κB Signaling by Recruiting the Phosphatase PP1 to Deactivate the IKK Complex. Journal of Molecular Cell Biology. 7 (6): 529-542. doi: 10.1093/jmcb/mjv041. 9. Liu Y, Yang YF, Fan JL, He RN, Luo M, Zheng XF*. (2015) The Crystal Structure of PB2 Cap-binding Domain of Influenza B Virus Reveals a Novel Cap Recognition Mechanism. J Biol. Chem. 290(14): 9141-9149. 10. Li TT, Guan J, Li SZ, Zhang XD, Zheng XF*. (2014) HSCARG downregulates TNF-induced NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination. Cell Difference & Diseases.5: e1229. Doi: 10.1038/cddis.2014.197. 11. Hu B, Li SZ, Zhang XD, Zheng XF*. (2014) HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. Nucleic Acid Res. 42, 5582-5593 12. Li G, Qu L, Ma S, Wu Y, J CW, Zheng XF*. (2014) Structures determination of human Fas Apoptosis Inhibitory Molecule and identification of the critical residues linking the interdomain interaction to the anti-apoptotic activity. Acta crystallographica section D. D70, 1812-1822. 13. Peng YY, Xu RD, Zheng XF*. (2014) HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. PloS Pathogens. 10(4): e1004041. 14. Li TT, Guan JH, Huang ZJ, Hu X, Zheng XF*. (2014) RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair. J Cell Sci. 127: 2238-2248. 15. Zhang JF, Bai DM, Ma XW, Guan JH, Zheng XF*. (2014) hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14. Oncogene. 33, 246-254. doi: 10.1038/onc.2012.560. 16. Xiao W, Meng G, Zhao Y, Yuan H, Li T, Peng Y, Zhao Y, Luo M, Zhao, WM, Li Z, Zheng XF*. (2014) Human SI-CLP aggravates the inflammation of the arthritis and is a potential macrophage inflammatory regulator. Arthritis Rheumatol. 66(5):1141-1152. 17. Bai DM, Zhang J, Xiao WC, Zheng XF*. (2014) Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress. Nucleic Acid Res. 42(3):1799-1811. 18. Meng G, An X, Ye, S, Liu Y, Zhu W, Zhang R, Zheng XF*. (2013) The crystal structure of LidA, a translocated substrate of the Legionella pneumophila Type IV secretion system, reveals a novel folding. Protein & Cell. 4(12):897-900. 19. Bai XY, Zheng XF*. (2013) Tip-to-tip interaction in the crystal packing of PACSIN 2 is important in regulating tubulation activity. Protein & Cell. 4(3): 211–219. 20. Xiao WC, Peng YY, Liu Y, Li Z, Li SL, Zheng XF*. (2013) HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox. PLoS One. 8(3): e59301.