个人简历

肖瑞平教授，现任北京大学分子医学研究所所长，国家杰出青年基金获得者，北京大学终身讲席教授。\r
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肖瑞平教授于1987年在同济医科大学生理学系获医学硕士学位；1995年获得马里兰大学生物学博士学位，2003年获聘NIH 终身资深研究员，2006年获NIH 首批女科学家顾问研究员奖。2010年3月辞去美国NIH终身资深研究员职位，全时在北京大学工作。肖瑞平教授兼具分子生物学和转化医学背景，长期从事心血管及代谢疾病药物靶点研究；迄今已在国际一流学术刊物上发表论文100余篇，引用9000余次。担任包括《新英格兰医学杂志》副主编在内的多个国际权威杂志副主编/编委

研究领域

""长期从事心血管及代谢疾病药物靶点研究""""

近期论文

1. Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by β2-adrenergic signaling in adult mouse cardiac myocytes. Proc Nat Acad Sci USA. 98: 1607-1612, 2001.\r
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2. Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kolbilka BK, Cheng H, Xiao RP. Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/Calmodulin Kinase II. J Clin Invest. 111: 617-625, 2003.\r
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3. Xiao RP, Zhang SJ, Chakir K, Avdonin P, Zhu W, Bond RA, Balke CW, Lakatta EG, Cheng H. Enhanced Gi signaling selectively negates β1-AR but not β1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation. 108: 1633-1639, 2003. \r
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4. Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature. 494: 375-379, 2013.\r
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5. Liu F, Song R, Feng Y, Guo J, Chen Y, Zhang Y, Chen T, Wang Y, Huang Y, Li CY, Cao C, Zhang Y, Hu X, Xiao RP. Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of PPAR α. Circulation. 131: 795-804, 2015.\r
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6. Zhang T, Zhang Y, Cui M, Jin L, Wang Y, Lv F, Liu Y, Zheng W, Shang H, Zhang J, Zhang M, Wu HK, Guo J, Zhang X, Hu X, Cao CM, Xiao RP. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med. 22: 175-182, 2016.