个人简历

教育经历: 1999-2005, 理学博士, 生命科学, 北京大学 1995-1999, 理学学士, 生命科学, 北京大学 工作经历: 2011 - 至今 , 研究员 , 北京大学，生命科学学院 2005 - 2011 , 博士后 , 美国国立卫生研究院（National Institutes of Health，NIH ）

研究领域

""建立与DNA修复相关的蛋白相互作用网络。\r
寻找与DNA修复和（/或）人类疾病相关的新蛋白，并研究其功能。\r
了解RNA拓扑异构酶在RNA代谢中的功能，及与精神分裂症和自闭症等神经发育疾病的关系。""""

近期论文

1. Xu R, Xu Y, Huo W, Lv Z, Yuan J, Ning S, Wang Q, Hou M, Gao G, Ji J, Chen J, Guo R#, Xu D#. A mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation. Proc Natl Acad Sci U S A. 2018. pii: 201806665. doi: 10.1073/pnas.1806665115. [Epub ahead of print] 2. Gao S, Feng S, Ning S, Liu J, Zhao H, Xu Y, Shang J, Li K, Li Q, Guo R#, Xu D#. An OB-fold complex controls the repair pathways for DNA double-strand breaks. Nature Communications 2018;9(1):3925. 3.Xu Y, Ning S, Wei Z, Xu R, Xu X, Xing M, Guo R#, Xu D#. 53BP1 and BRCA1 control pathway choice for stalled replication restart.Elife. 2017 Nov 6;6. pii: e30523. This work was recommended in F1000 `Access 4.Ahmad M, Shen W, Li W, Xue Y, Zou S, Xu D#, Wang W#. Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction. Nucleic Acids Res. 2017 Mar 17;45(5):2704-2713 (# co-corresponding author) 5.Feng S, Zhao Y, Xu Y, Ning S, Hou W, Hou M, Gao G, Ji J, Guo R, Xu D#. Ewing Tumor-Associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks. J Biol Chem. 2016 Oct 14;291(42):21956-21962 This work was selected as `Highlights of 2016` of J Biol Chem. 6. Ahmad M, Xue Y, Lee SK, Martindale JL, Shen W, Li W, Zou S, Ciaramella M, Debat H, Nadal M, Leng F, Zhang H, Wang Q, Siaw GE, Niu H, Pommier Y, Gorospe M, Hsieh TS, Tse-Dinh YC, Xu D#, Wang W#. RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. Nucleic Acids Res. 2016 Jul 27;44(13):6335-49 (# co-corresponding author) 7. Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D# , Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nature Communications, 2015, 6:6233 8. Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D#, Durocher D.A# , A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice. Mol Cell. , 2013 , 49(5):872-83 (# co-corresponding author) Highlighted by: Science（2013;339:652），Nat Cell Biol. （2013;15:240）and Mol Cell.（2013;49:840） 9. Xu D.*, Shen W.*, Guo R., Xue Y., Yang J., Sharov A., Srikantan S., Yang J., Fox D., Peng W., Qian Y., Martindale J., Piao Y., Machamer J., Joshi S., Mohanty S., Shaw A., Lloyd T., Brown G., Ko M., Gorospe M., Zou S., Wang W. , Top3β is an RNA topoisomerase that interacts with Fragile X syndrome protein to promote synapse formation. Nature Neuroscience , 2013 , 16, 1238–1247(*co-1st author) Highlighted by: Nature（v500, page125）and The Scientist（August 6, 2013） 10. Xu D, Muniandy P, Leo E, Yin J, Thangavel S, et al. , Rif1 provides a new DNA binding interface for the Bloom syndrome complex to maintain normal replication. , EMBOJ , 2010 , 29:3140-3155 11. Hoadley K.A., Xu D, Xue Y, Satyshur K.A., Wang W, and Keck J.L. , Structure and cellular roles of the RMI core complex from the Bloom syndrome dissolvasome. , Structure , 2010 , 18:1149-1158 13. Guo R*, Xu D*, Wang W , Identification and analysis of new proteins involved in the DNA damage response network of Fanconi anemia and Bloom syndrome. , Methods , 2009 , 48: 72-79(*co-1st author) 14. Xu D*, Guo R*, Sobeck A, Bachrati CZ, Yang J, et al. , RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. , Genes Dev , 2008 , 22: 2843-2855(*co-1st author) Highlighted by：Nature（456:453-454, 2008）， Nature Rev. Mol. Cell.Biol. (9:920, 2008) and Genes & Dev. （22:2737-2742, 2008） 15. Xu D, Yu X, Guo C, Zhao J , Construction of a non-antibiotic expression system in a marine cyanobacterium Synechococcus sp PCC 7002 and its application in production of oral vaccine against enterotoxin of Escherichia coli. , Journal of Applied Phycology , 2006 , 18: 127-134. 16. Xu D, Liu X, Guo C, Zhao J , Methylglyoxal detoxification by an aldo-keto reductase in the cyanobacterium Synechococcus sp. PCC 7002. , Microbiology , 2006 , 152: 2013-2021. 17. Xu D, Liu X, Zhao J , FesM, a membrane iron-sulfur protein, is required for cyclic electron flow around photosystem I and photoheterotrophic growth of the cyanobacterium Synechococcus sp. PCC 7002. , Plant Physiol , 2005 , 138: 1586-1595.