个人简历

汪阳明教授于2000年本科毕业于北京大学生物技术系, 获理学学士学位，2006年获美国伊利诺斯大学(Urbana-Champaign)生物化学专业博士学位。2006-2010年在加州大学（San Francisco）从事博士后研究，现任北京大学分子医学研究所全职教授。

研究领域

主要从事非编码小核酸在胚胎干细胞中功能的研究。建立microRNA 全敲除小鼠胚胎干细胞，率先证明了microRNA 作为一个群体对于胚胎干细胞增殖与分化具有重要功能，从而为这个领域的进一步研究指明了方向。 随后，利用这些microRNA 敲除小鼠胚胎干细胞，发展了一套筛选microRNA功能的新方法， 并发现了调控胚胎干细胞的增殖与细胞周期的重要microRNA 簇。 这个发现直接启发了其它与此microRNA簇相关的功能的研究， 包括它们对胚胎干细胞全能性以及体细胞重编程成为诱导多能干细胞过程中的作用

近期论文

29. #Wang, X.W., #Hu, L.F., Hao, J., Liao, L.Q., Chiu, Y.T., Shi, M.and *Wang Y. (2019) A microRNA-inducible CRISPR-Cas9 platform serves as a microRNA sensor and cell-type-specific genome regulation tool. Nature Cell Biology 21, 522-530.
28. #Li, Y.P., #Duan, F.F., Zhao, Y.T., Gu, K.L., Liao, L.Q., Su, H.B., Hao, J., Zhang, K., Yang, N. and *Wang Y. (2019) A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells. Nature Communications 10, 1368.
27. Guo, W.T. and *Wang Y. (2019) Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo. Cellular and Molecular Life Sciences doi: 10.1007/s00018-019-03020-9.
26. Wu, D.R., Gu, K.L., Yu, J.C., Fu, X., Wang, X.W., Guo, W.T., Liao, L.Q., Zhu, H., Zhang, X.S., *Hui J and *Wang Y. (2018) Opposing roles of miR-294 and MBNL1/2 in shaping the gene regulatory network of embryonic stem cells. EMBO Reports 19, e45657.
25. Bao, X., Guo, X., Yin, M., Tariq, M., Lai, Y., Kanwal, S., Zhou, J., Li, N., Lv, Y., Pulido-Quetglas, C., Wang, X., Ji, L., Khan, M.J., Zhu, X., Luo, Z., Shao, C., Lim, D.H., Liu, X., Li, N., Wang, W., He, M., Liu, Y.L., Ward, C., Wang, T., Zhang, G., Wang, D., Yang, J., Chen, Y., Zhang, C., Jauch, R., Yang, Y.G., Wang, Y., Qin, B., Anko, M.L., Hutchins, A.P., Sun, H., Wang, H., Fu, X.D., Zhang, B., Esteban, M.A. (2018) Capturing the interactome of newly transcribed RNA. Nature Methods 15，213-220.
24. Chen, X., Wang, L., Huang, R., Qiu, H., Wang, P., Wu, D., Zhu, Y., Ming, J., Wang, Y., Wang, J. and *Na, J. (2018) Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program. Protein & Cell doi: 10.1007/s13238-018-0572-1.
23. Jiang, L., Shao, C., Wu, Q.J., Chen, G., Zhou, J., Yang, B., Li, H., Gou, L.T., Zhang, Y., Wang, Y., Yeo, G.W., Zhou, Y., Fu, X.D. (2017) NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing. Nature Structural and Molecular Biology 24，816-824.
22. Wang, X.W., Hao, J., Guo, W.T., Liao, L.Q., Huang, S., Guo, X., Bao, X., Esteban, M.A. and *Wang, Y. (2017) DGCR8-independent stable microRNA expression strategy reveals important functions of miR-290 and miR-183~182 families in mouse embryonic stem cells. Stem Cell Reports 9，1618-1629.
21. Wei, W., Liu, Y., Zhang, Q., Wang, Y., Zhang, X. and *Zhang H. (2017) Danshen-Enhanced Cardioprotective Effect of Cardioplegia on Ischemia Reperfusion Injury in a Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Model. Artificial Organs 41:452-460.
20. #Gu, K.L., #Zhang, Q., #Yan, Y., #Li, T.T., Duan, F.F., Hao, J., Wang, X.W., Shi, M., Wu, D.R., Guo, W.T., *Wang, Y. (2016) Pluripotency Associated miR-290/302 Family of microRNAs Promote the Dismantling of Naive Pluripotency. Cell Research 26, 350-366.
19. #Cao, Y., #Guo, W.T., Tian, S., He, X., Wang, X.W., Liu, X., Gu, K.L., Ma, X., Huang, D., Cai, Y.P., Zhang, H., *Wang, Y. and *Gao, P. (2015) miR-290/371-Mbd2-Myc Circuit Regulates Glycolytic Metabolism to Promote Pluripotency. EMBO Journal 34, 609-623.
18. #Yan, Y., #Yang, X., Li, T.T., Gu, K.L., Hao, J., Zhang, Q., *Wang, Y. (2017) Significant Differences of Function and Expression of microRNAs between Ground State and Serum-Cultured Pluripotent Stem Cells. Journal of Genetics and Genomics 44，179-189.
17. Guo, W.T., Wang, X.W., Yan, Y.L., Li, Y.P., Yin, X., Zhang, Q., Melton, C., Shenoy, A., Reyes, N.A., Oakes, S.A., *Blelloch, R. and *Wang Y. (2015) Suppression of Epithelial-Mesenchymal Transition and Apoptotic Pathways by miR-294/302 Synergistically Blocks let-7-induced Silencing of Self-renewal in Embryonic Stem Cells. Cell Death and Differentiation 22, 1158-1169.
16. #Ma, Y., #Yao, N., #Liu, G., Dong, L., Wang, F., Wang, B., Dong, H., Wei, X., Zhang, M., Ji, S., Liu, Y., Zhang, J., Wang Y, *Huang Y. and *Yu J. (2015) Functional Screen Reveals Essential Roles of miR-27a/24 in Differentiation of Embryonic Stem Cells. EMBO Journal 34, 361-378.
15. *#Wang, Y., #Melton, C., Li, Y.P., Shenoy, A., Zhang, X.X., Subramanyam, D. and *Blelloch, R. (2013) miR-294/miR-302 Promotes Proliferation, Suppresses G1-S Restriction Point, and Inhibits ESC Differentiation through Separable Mechanisms. Cell Reports 4, 99-109.
14. Wang, Y., Baskerville, S., Shenoy, A., Babiarz, J.E., Baehner, L. and *Blelloch, R. (2008) Embryonic Stem Cell Specific microRNAs Regulate the G1/S Transition and Promote Rapid Proliferation. Nature Genetics 40, 1478-1483. (Highlighted in Nature Reports Stem Cells ; in News and Views in Nature Genetics , 2008, 40, 1391-1392; and in Cell Stem Cell , 2009, 4, 9-10)
13. Babiarz, J.E., Ruby, J.G., Wang, Y., *Bartel, D.P. and *Blelloch, R. (2008) Endogenous shRNAs, siRNAs, and Other Microprocessor-independent, Dicer-dependent Small RNAs in Mouse ES cells. Genes & Development 22, 2773-2785.
12. Wang, Y., Medvid, R., Melton, C., Jaenisch, R. and *Blelloch, R. (2007) DGCR8 is Essential for microRNA Biogenesis and Silencing of Embryonic Stem Cell Self-Renewal. Nature Genetics 39, 380-385.
11. Wang, Y. and *Silverman, S.K. (2006) Experimental Tests of Two Proofreading Mechanisms for 5′-Splice Site Selection. ACS Chemical Biology 1, 316-324.
10. Wang, Y. and *Silverman, S.K. (2006) Efficient RNA 5'-Adenylation By T4 DNA Ligase to Facilitate Practical Applications. RNA 12, 1142-1146.