个人简历

简介
　　植物叶片是植物光合作用的重要器官，与功能相适应，在长期的进化过程中许多植物形成了能够捕获最大光能的扁平的叶片，叶子的扁平形态对于植物发育来说并不是简单容易的过程，该过程涉及到叶边缘细胞和叶中间细胞的分化和生长的协调，如果不能有效协调，叶子扁平的生长平衡将不能维持，出现非扁平的表型。为了揭示叶片发育的分子机理，我们从拟南芥T-DNA插入激活突变体库中筛选并获得多个叶片发育异常的突变体包括叶片卷曲的突变体，通过分析一个卷叶突变体iamt1-D，我们发现植物生长素的甲基化修饰通过影响TCP转录因子来调控植物叶片的扁平发育。目前正在用遗传学和分子生物学的方法对其他一些新的叶片发育缺陷的突变体进行分析，通过这些研究，将加深我们对植物叶片发育的调控机理的理解，最终可利用这些叶片发育相关的基因调控植物的生长模式来为农业生产服务。

研究领域

植物叶片发育保守转录调控分子机制的研究： 叶片是光合作用的主要器官。叶片在地球上的出现彻底改变了地球表面和大气的环境，也改变了植物和动物的进化方向。早在300多年前，德国著名的自然科学家兼哲学家戈特弗里德•威廉•莱布尼茨 (Gottfried Wilhelm Leibniz) 就指出世界上没有两片完全相同叶片的自然现象，叶片形态的多样性使其成为重要的分类依据，但叶片也有统一性，比如很多叶片都是平整的。叶片如何进化而来？叶片如何根据不同的环境形成多种多样的大小和形态？又怎样形成平整的结构为进行光合作用来高效捕获光能？这些科学问题还远没有研究清楚。本课题组的研究方向主要是根据这些科学问题，以模式植物拟南芥和水稻为材料，利用遗传学、分子生物学和生物化学的方法，寻找和克隆调控叶片发育相关的重要保守关键基因，研究重要转录因子TCP、EXB蛋白家族、转录抑制因子TIE蛋白家族以及与染色质重塑因子相关的TPL/TPRs蛋白家族在调控叶片和其他器官发育中的保守分子机制，完善调控叶片发育的分子调控网络，为叶片与侧枝间的进化关系提供可能的分子证据，加深理解叶片形成平整以及不同形态和大小的分子机理，为通过分子设计育种改造植物株型和叶片大小和形态来提高农作物产量提供理论基础。"研究领域：植物器官发育的分子机理"

近期论文

1. Rongrong Yuan, Jingqiu Lan, Yuxing Fang, Hao Yu, Jinzhe Zhang, Jiaying Huang and Genji Qin* (2018) The Arabidopsis USL1 controls multiple aspects of development by affecting late endosome morphology. New Phytologist 219(4):1388-1405. 2. Yan Yang#, Michael Nicolas#, Jinzhe Zhang, Hao Yu, Dongshu Guo, Rongrong Yuan, Tiantian Zhang, Jianzhao Yang, Pilar Cubas*, Genji Qin* (2018) The TIE1 transcriptional repressor controls shoot branching by directly repressing BRANCHED1 in Arabidopsis. PLoS Genetics 14(3): e1007296. 3. Shaoman Zhang, Cong Li, Yangyang Zhou, Xiaoji Wang, Hong Li, Ziyi Feng, Haodong Chen, Genji Qin, Dan Jin, William Terzaghi, Hongya Gu, Li-Jia Qu, Dingming Kang, Xing Wang Deng, Jigang Li (2018) TANDEM ZINC-FINGER/PLUS3 Is a Key Component of Phytochrome A Signaling. Plant Cell 30(4): 835-852. 4. Wenxing Han, Danlu Han, Zhipeng He, Huan Hu, Qian Wu, Juanjuan Zhang Jieming Jiang, Genji Qin, Yuhai Cui, Jianbin Lai, Chengwei Yang (2018). The SWI/SNF subunit SWI3B regulates IAMT1 expression via chromatin remodeling in Arabidopsis leaf development. Plant Science 271: 127-132. 5. Jinzhe Zhang, Baoye Wei, Rongrong Yuan, Jianhui Wang, Mingxin Ding, Zhuoyao Chen, Hao Yu, Genji Qin* (2017). The Arabidopsis RING-type E3 ligase TEAR1 controls leaf development by targeting the TIE1 transcriptional repressor for degradation. Plant Cell 29(2): 243-259. 6. Dongshu Guo, Genji Qin* (2016). EXB1/WRKY71 transcription factor regulates both shoot branching and responses to abiotic stresses. Plant Signaling & Behavior. 11(3): e1150404. 7. Shibai Li, Xiaochen Wang, Shan He, Jieru Li, Qingpei Huang, Takato Imaizumi, Leqing Qu, Genji Qin, Li-Jia Qu, and Hongya Gu* (2016). CFLAP1 and CFLAP2 Are Two bHLH Transcription Factors Participating in Synergistic Regulation of AtCFL1-Mediated Cuticle Development in Arabidopsis. PLoS Genetics. 12(1): e1005744. 8. Dongshu Guo, Jinzhe Zhang, Xinlei Wang, Xiang Han, Baoye Wei, Jianqiao Wang, Boxun Li, Hao Yu, Qingpei Huang, Hongya Gu, Li-Jia Qu, Genji Qin* (2015). The WRKY transcription factor WRKY71/EXB1 controls shoot branching by transcriptionally regulating RAX genes in Arabidopsis. Plant Cell 27: 3112-3127. (cover story) 9. Qing Liu, Gezhi Shen, Keqin Peng, Zhigang Huang, Jianhua Tong, Mohammed Humayun Kabir, Jianhui Wang, Jingzhe Zhang, Genji Qin* and Langtao Xiao* (2015). The alteration in the architecture of a T-DNA insertion rice mutant osmtd1 is caused by up-regulation of MicroRNA156f. Journal of Integrative Plant Biology 57(10):819-829. 10. Baoye Wei, Jinzhe Zhang, Changxu Pang, Hao Yu, Dongshu Guo, Hao Jiang, Mingxin Ding, Zhuoyao Chen, Qing Tao, Hongya Gu, Li-Jia Qu, Genji Qin* (2015). The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development. Cell Research 25:121-134. 11. Yan Yang, Bin Ou, Jinzhe Zhang, Hongya Gu, Genji Qin and Li-Jia Qu (2014). The Arabidopsis Mediator subunit MED16 regulates iron homeostasis by associating with EIN3/EIL1 through subunit MED25. Plant Journal 77(6):838-851. 12. Ruixi Li, Jieru Li, Shibai Li, Genji Qin, Ondrej Novak, Ales Pencik, Karin Ljung，Takashi Aoyama, Jingjing Liu, Angus Murphy, Hongya Gu, Tomohiko Tsuge, Li-Jia Qu (2014). ADP1 Affects Plant Architecture by Regulating Local Auxin Biosynthesis. PLOS Genetics 10(1): e1003954. 13. Jin Miao#, Dongshu Guo#, Jinzhe Zhang#, Qingpei Huang#, Genji Qin#, Xin Zhang,Jianmin Wan, Hongya Gu, Li-Jia Qu* (2013). Targeted mutagenesis in rice using CRISPR-Cas system. Cell Research 23(10):1233-1236. 14. Tong Wei, Bin Ou, Jinbin Li, Yang Zhao, Dongshu Guo, Youyong Zhu, Zhangliang Chen, Hongya Gu, Chengyun Li*, Genji Qin* and Li-Jia Qu* (2013). Transcriptional profiling of rice early response to Magnaporthe oryzae identified OsWRKYs as important regulators in rice blast resistance. PLoS ONE 8(3): e59720. 15. Qing Tao, Dongshu Guo, Baoye Wei, Fan Zhang, Changxu Pang, Hao Jiang, Jinzhe Zhang, Tong Wei, Hongya Gu, Li-Jia Qu, Genji Qin* (2013). The TIE1 Transcriptional Repressor Links TCP Transcription Factors with TOPLESS/TOPLESS-RELATED Corepressors and Modulates Leaf Development in Arabidopsis. Plant Cell 25: 421-437 16. Yan Chen, Zhangliang Chen, Juqing Kang, Dingming Kang, Hongya Gu, Genji Qin* (2013). AtMYB14 Regulates Cold Tolerance in Arabidopsis. Plant Molecular Biology Reporter 31: 87-97. 17. Mingqiu Dai, Chen Zhang, Urszula Kania, Fang Chen, Qin Xue, Tyra Mccray, Gang Li, Genji Qin, Michelle Wakeley, William Terzaghi, ,Jianmin Wan, Yunde Zhao, Jian Xu, Jiří Friml, Xing Wang Deng and Haiyang Wang (2012). A novel PP6-type phosphatase holoenzyme directly regulates PIN phosphorylation and auxin efflux in Arabidopsis. Plant Cell 24: 2497-2514. 18. Wei-ying Wang, Li Zhang, Shufan Xing, Zhiqiang Ma, Jingjing Liu, Hongya Gu, Genji Qin* and Li-jia Qu* (2012). Arabidopsis AtVPS15 plays essential roles in pollen germination possibly by interacting with AtVPS34. Journal of Genetics and Genomics 39: 81-92. 19. Yang Zhao, Tong Wei, Kang-Quan Yin, Zhangliang Chen, Hongya Gu, Li-Jia Qu and Genji Qin*（2012）. Arabidopsis RAP2.2 plays an important role in plant resistance to Botrytis cinerea and ethylene responses. New Phytologist 195: 450-460.