个人简历

北京大学心血管研究所研究员，分子心血管教育部重点实验室PI，血管医学卫生部重点实验室PI，北京大学医学部基础医学院药理学专业博士生导师。2004年毕业于中国药科大学获理学博士学位。2008-2010年美国密西根大学安娜堡分校医学院Research Investigator。台湾大学客座教授，石河子大学医学院“绿洲学者”讲座教授。担任中国药理学会心血管药理专业委员会委员，中国药理学会生化与分子药理专业委员会委员。先后主持6项国家自然科学基金项目和2项973子课题骨干项目的研究。近五年在相关研究领域的优秀国际期刊上，以通讯作者共发表SCI论文22篇，平均影响因子5.12。所发表的研究论文曾荣获北京大学医学部优秀SCI论文引用奖、基础医学院优秀SCI论文奖及论文引用奖。

研究领域

研究兴趣主要是从天然或合成的小分子化合物中，筛选发现对心脏重构、腹主动脉瘤和脂肪肝等常见并高发的心血管疾病具有显著抑制活性的药物，明确药物的作用机制与靶点，并设计药物的体内递送方式以提高药物的吸收与药效作用，致力于心血管疾病的防治与新药研究

近期论文

Wang YX(#), Chen C, Wang QY, Cao YN, Xu L, Qi R*. Inhibitory Effects of Cycloastragenol on Abdominal Aortic Aneurysm and its Related Mechanisms.Br J Pharmacol. 2018 Oct 10. doi: 10.1111/bph.14515. (IF=6.81)
Cao YN(#), Baiyisaiti A, Wong CW, Hsu SH*, Qi R*. Polyurethane Nanoparticle-Loaded Fenofibrate Exerts Inhibitory Effects on Nonalcoholic Fatty Liver Disease in Mice.Mol Pharm. 2018 Oct 1;15(10):4550-4557. doi: 10.1021/acs.molpharmaceut.8b00548. (IF=4.56)
Yu MM(#), Dong AJ(#), Chen C, Xu S, Cao YN, Liu S, Zhang Q, Qi R*, Thermosensitive Hydrogel Containing Doxycycline Exerts Inhibitory Effects on Abdominal Aortic Aneurysm Induced By Pancreatic Elastase in Mice, Adv Healthc Mater. 2017 Nov 6;(22). doi: 10.1002/adhm.201700671.(IF 5.76)
Wang C(#),Wang YX (#),Yu MM(#),Chen C, Xu L, Cao YN, Qi R*，Grape-seed Polyphenols Play a Protective Role in Elastase-induced Abdominal Aortic Aneurysm in Mice，Sci Rep，2017 Aug 24;7(1):9402. doi: 10.1038/s41598-017-09674-4. (IF= 4.26)
Chen C, Jie X, Cao YN, Qi R*. Nanoliposome Improves Inhibitory Effects of Naringenin on Nonalcoholic Fatty Liver Disease in Mice. Nanomedicine (UK), 2017 Jul 18. doi: 10.2217/nnm-2017-0119. (IF 4.9)
Tuerdi N, Xu L, Zhu B, Chen C, Cao Y, Wang Y, Zhang Q, Li Z, Qi R*. Preventive effects of simvastatin nanoliposome on isoproterenol-induced cardiac remodeling in mice.Nanomedicine-NBM. 2016, 2(7):1899-1907. doi: 10.1016/j.nano.2016.05.002. (IF 6.16)
Qi R#*, Li YZ, Chen C, Cao YN, Yu MM, Xu L, He B, Jie X, Shen WW, Wang YN, van Dongen MA, Liu GQ, Banaszak Holl MM, Zhang Q, Ke X.G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol.J Control Release. 2015 Jul 28;210:160-8. doi: 10.1016/j.jconrel.2015.05.281. (IF 7.26)
Tang Y, Li YB, Wang B, Lin RY, van Dongen M, Zurcher DM, Gu XY, Banaszak Holl MM, Liu GQ, Qi R*. Efficient in vitro siRNA delivery and potent gene silencing in vivo using PEG-modified PAMAM dendrimers. Mol Pharm, 2012, 9: 1812-1821. doi: 10.1021/mp3001364. (IF 5.4)
Qi R#, Gao Y, Tang Y, He RR, Liu TL, He Y, Sun S, Li BY, Li YB, Liu G. PEG-conjugated PAMAM dendrimers mediate efficient intramuscular gene expression.AAPS J, 2009, 11(3): 395-405. (IF 5.52)
Zhang X#, Qi R#, Xian X, Yang F, Blackstein M, Deng X, Fan J, Ross C, Karasinska J, Hayden MR, Liu G. Spontaneous Atherosclerosis in Aged Lipoprotein Lipase–Deficient Mice With Severe Hypertriglyceridemia on a Normal Chow Diet. Circulation Res, 2008, 102 (2): 250-256.(IF 9.99)