个人简历

2013起，预备研究员，博士生导师，北京大学－清华大学生命科学联合中心\r
2013起，研究员，博士生导师，北京大学化学与分子工程学院\r
2011-2013 ，博士后 ，美国H3生物制药公司\r
2005-2011 ，理学博士，美国哈佛大学化学与化学生物学系\r
2001-2005 ，理学学士，北京大学化学与分子工程学院

研究领域

"""""本研究小组将致力于发展和应用有机化学的新反应、新方法，并以此为工具来推动生命科学

近期论文

Guan, C., Niu, Y., Chen, S. et al. Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun 11, 2478 (2020).\r
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Cai, Y., Zhou, H., Zhu, Y. et al. Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res (2020). https://doi.org/10.1038/s41422-020-0314-9\r
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Late-Stage Diversification of Natural Products Benke Hong Tuoping Luo, and Xiaoguang Lei. ACS Central Science 2020 6 (5), 622-635.\r
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Total Synthesis of (–)-Batrachotoxinin A: A Local-Desymmetrization Approach Guo, Y.; Guo, Z.; Lu, J.-T.; Fang, R.; Chen, S.-C.; Luo, T. J. Am. Chem. Soc. 2020, 142, 3675−3679.\r
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Synthesis of 17-Deacetoxyl Chromodorolide B Based on a Gold-Catalyzed Alkoxycyclization Reaction Li, C.; Quan, T.; Xue, Y.; Cao, Y.; Chen, S.-C.; Luo, T. Org. Lett. 2020, 22, 1655−1658.\r
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Total Synthesis of (−)-Oridonin: An Interrupted-Nazarov Approach Kong, L.; Su, F.; Yu, H.; Jiang, Z.; Lu, Y.; Luo, T. J. Am. Chem. Soc. 2019, 141, 20048−20052.\r
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A Modular PROTAC Design for Target Destruction Using A Degradation Signal Based on A Single Amino Acid Shanmugasundaram, K.; Shao, P.; Chen, H.; Campos, B.; McHardy, S. F.; Luo, T.; Rao, H. J. Biol. Chem. 2019, 294, 15172-15175.\r
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Scalable Total Synthesis of (−)-Vinigrol Yu, X.; Xiao, L.; Wang, Z.; Luo, T. J. Am. Chem. Soc. 2019, 141, 3440-3443.\r
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Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles Lu, Y.; Zhao, S.; Zhou. S.; Chen, S.-C.; Luo, T. Org. Biomol. Chem. 2019, 17, 1886-1892.\r
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Chemoproteomics Reveals Baicalin Activates Hepatic CPT1 to Ameliorate Diet-induced Obesity and Hepatic Steatosis Dai, J.; Liang, K.; Zhao, S.; Jia, W.; Liu, Y.; Wu, H.; Lv, J.; Cao, C.; Chen, T.; Zhuang, S.; Hou, X.; Zhou, S.; Zhang, X.; Chen, X.-W.; Huang, Y.; Xiao, R.-P.; Wang, Y.-L.; Luo, T.; Xiao, J.; Wang, C. Proc. Natl. Acad. Soc., USA 2018, 115, E5895-E5905.\r
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Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon Su, F.; Lu, Y.; Kong, L.; Liu, J.; Luo, T. Angew. Chem. Int. Ed. 2018, 57, 760-764.\r
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Simple β-Lactones are Potent Irreversible Antagonists for Strigolactone Receptors Xiang, H.; Yao, R.; Quan, T.; Wang, F.; Chen, L.; Du, X.; Zhang, W.; Deng, H.; Xie, D.; Luo, T. Cell Res. 2017, 27, 1525-1528.\r
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An Unexpected Aziridination/Rearrangement/Oxidation Tandem Reaction Leading to the Total Synthesis of (−)-Mersicarpine Zhang, Y.; Xue, Y.; Luo, T. Tetrahedron 2017, 73, 4201-4205.\r
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Enantioselective Total Synthesis of (+)-Wortmannin Guo, Y.; Quan, T.; Lu, Y.; Luo, T. J. Am. Chem. Soc. 2017, 139, 6815-6818.\r
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Synthesis of (+)-Lysergol and Its Analogues To Assess Serotonin Receptor Activity Yuan, H.; Guo, Z.; Luo, T. Org. Lett. 2017, 19, 624-627.\r
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Total Syntheses of (−)-Hibiscone C and Lysergine: A Cyclization/Fragmentation Strategy Lu, Y.; Yuan, H.; Zhou, S.; Luo, T. Org. Lett. 2017, 19, 620-623.\r
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Enantioselective Synthesis of Iboga Alkaloids and Vinblastine via rearrangements of quaternary ammoniums Zhang, Y.; Xue, Y.; Li, G.; Yuan, H.; Luo T. Chem. Sci. 2016, 7, 5530-5536.\r
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Enantioselective Total Syntheses of Various Amphilectane and Serrulatane Diterpenoids via Cope Rearrangements Yu, X.; Su, F.; Liu, C.; Yuan, H.; Zhao, S.; Zhou, Z.; Quan, T.; Luo T. J. Am. Chem. Soc. 2016, 138, 6261-6270.\r
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Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution:application in protein labelling Zhao, S.; Dai, J.; Hu, M.; LIu, C.; Meng, R.; Liu, X.; Wang, C.; Luo, T. Chem. Commun. 2016, 52, 4702-4705. \r
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Gold-Catalyzed Enantio- and Diastereoselective Syntheses of Left Fragments of Azadirachtin/Meliacarpin-Type Limonoids Shi, H.; Tan, C.; Zhang, W.; Zhang, Z.; Long, R.; Gong, J.; Luo, T.; Yang, Z. J. Org. Chem. 2016, 81, 751-771.\r
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Towards a general diastereoselective route to oxabicyclo[3.2.1]octanes via a gold-catalysed cascade reaction Fu, J.; Gu, Y.; Yuan, H.; Luo, T.; Liu, S.; Lan, Y.; Gong, J.; Yang, Z. Nature Communications 2015, 6, 8617.\r
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Synthetic Progress toward Azadirachtins. 1. Enantio- and Diastereoselective Synthesis of the Left-Wing Fragment of 11-epi-Azadirachtin I Shi, H.; Tan, C.; Zhang, W.; Zhang, Z.; Long, R.; Luo, T.; Yang, Z. Org. Lett. 2015, 17, 2342-2345.\r
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Synthetic Progress toward Azadirachtins. 2. Enantio- and Diastereoselective Synthesis of the Right-Wing Fragment of 11-epi-Azadirachtin I Tan, C.; Chen, W.; Mu, X.; Chen, Q.; Gong, J.; Luo, T.; Yang, Z. Org. Lett. 2015, 17, 2338-2341.