个人简历

2004年毕业于华中科技大学获得药学学士学位，同年进入国家药品审评中心工作，2010年取得沈阳药科大学硕士学位，2011-2014年就读于北京大学药学院并获得药剂学博士学位；2014-2016年在北京大学基础医学院/美国西南医学中心从事博士后研究；2017年6月入职北京大学基础医学院系统生物医学研究所，为新体制教研系列Tenure track助理教授，副研究员。长期从事生物响应型材料在生物医学领域的应用及转化工作。研究开发的纳米晶-温度响应型凝胶已经获得中国专利授权及十二五“重大新药创制”项目的资助，并已转化实施。博士后期间研究的超pH敏感型荧光纳米探针已在欧洲完成I期临床研究。目前主持承担十三五“重大新药创制”科技重大专项课题（任务级）、省级重点实验室开放课题及北京大学医学部人才引进与启动基金，获北京市科技进步二等奖（第五完成人）。

研究领域

""生物响应型荧光纳米探针\r
新型纳米疫苗和原位免疫凝胶\r
高分子材料与蛋白之间的相互作用""""

近期论文

Lin Z, Gao W, Hu H, Ma K, Wang J, Zhang X, and Zhang Q*. (2014). Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity. Journal of Controlled Release 174, 161-170. （被ESI评为“Highly Cited Papers”）\r
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Lin Z, Mei D, Chen M, Dai W, Yin Y*, Dong A*, and Zhang Q*. A comparative study of thermo-sensitive hydrogels with water-insoluble paclitaxel in molecule, nanocrystal and microcrystal dispersions. (2015). Nanoscale 7, 14838-14847. （被选为Inside Back Cover）\r
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Ma Y#, Lin Z# (co-first author), Fallon J，Zhao Q, Liu D, Wang Y, Liu F (2015). New mouse xenograft model modulated by tumor-associated fibroblasts for human multi-drug resistance in cancer. Oncology Reports 2015.11.01,34（5）:2699~2705\r
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Mei D, Lin Z, Fu J, He B, Gao W, Ma L, and Zhang Q*. (2015). The use of alpha-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to alpha7 nAChR-overexpressing breast cancer. Biomaterials 42:52-65.\r
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Hu H, Lin Z, He B, Dai W, Wang X, Wang J, and Zhang Q*. (2015). A novel localized co-delivery system with lapatinib microparticles and paclitaxel nanoparticles in a peritumorally injectable in situ hydrogel. Journal of Controlled Release 220, 189-200.\r
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Lin Z, Xu S, Gao W, Hu H, Chen M, Dong A*, Yin Y*, and Zhang Q*.(2016). A comparative investigation between paclitaxel nanoparticle- and nanocrystal-loaded thermosensitive PECT hydrogels for peri-tumoural administration. Nanoscale 8, 18782-18791.\r
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Li Y, Zhao T, Wang C, Lin Z, Huang G, Sumer B, and Gao J*. (2016). Molecular basis of cooperativity in pH-triggered supramolecular self-assembly. Nature Communications 7(13214): 1-9\r
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Zhao T, Huang G, Li Y, Yang S, Ramezani S, Lin Z, Baran S, and Gao J*. (2016). A Transistor-like pH Nanoprobe for Tumour Detection and Image-guided Surgery. Nature Biomedical Engineering 1(0006): 1-8.\r
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Gao W,Yang X,Lin Z,He B,Mei D,Wang D,Zhang H,Zhang H,Dai W,Wang X,Zhang Q*. (2017).The use of electronic-neutral penetrating peptides cyclosporin A to deliver pro-apoptotic peptide: A possibly better choice than positively charged TAT. Journal of Controlled Release 261: 174-186