个人简历

2019-北京大学基础医学院 研究员\r
2012-2019 北京大学化学学院研究员\r
2009-2012 耶鲁大学医学院 博士后\r
2003-2009 印第安那大学化学系博士\r
2001-2003 密歇根州立大学化学系 硕士\r
1997-2001 吉林大学化学系 学士

研究领域

""课题组致力于发展高通量蛋白质组学方法以解决感染生物学领域一些因传统技术手段受限的重要科学问题。我们发展了高效、普适的胞内病原细菌蛋白质组分析新策略，为从整体层次揭示致病菌适应宿主的分子机制提供了新颖的视角。""""

近期论文

Li Z, Liu Y, Fu J, Zhang B, Cheng S, Wu M, Wang Z, Jiang J, Chang C, Liu X. (2019) Salmonella proteomic profiling during infection distinguishes the intracellular environment of host cells. mSystems, 4, e00314-18.\r
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Wang Z, Sun J, Tian M, Xu Z, Liu Y, Fu J, Yan A, Liu X. (2019) Proteomic analysis of FNR-regulated anaerobiosis in Salmonella Typhimurium. J. Am. Soc. Mass Spectrom., doi: 10.1007/s13361-019-02145-2.\r
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Wang Z, McCloskey A, Cheng S, Wu M, Xue C, Fu J, Liu Y, Luo ZQ, Liu X. (2018) Regulation of the small GTPase Rab1 function by a bacterial glucosyltransferase. Cell Discov., 4, 53.\r
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Wang Z, Sun J, Xia T, Liu Y, Fu J, Lo YK, Chang C, Yan A, Liu X. (2018) Proteomic delineation of the ArcA regulon in Salmonella Typhimurium during anaerobiosis. Mol. Cell. Proteomics, 17, 1937-1947.\r
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Zhang B, Ran L, Wu M, Li Z, Jiang J, Wang Z, Cheng S, Fu J, Liu X. (2018)Shigella flexneriregulator SlyA controls bacterial acid resistance by directly activating the glutamate decarboxylation system. Front. Microbiol.,9, 2071.\r
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Cheng S, Wang L, Liu Q, Qi L, Yu K, Wang Z, Wu M, Liu Y, Fu J, Hu M, Li M, Zhou D, Liu X. (2017) Identification of a novel Salmonella type III effector by quantitative secretome profiling. Mol. Cell. Proteomics, 16, 2219-2228.\r
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Liu Y, Liu Q, Qi L, Ding T, Wang Z, Fu J, Hu M, Li M, Song J, Liu X. (2017) Temporal regulation of a Salmonella Typhimurium virulence factor by the transcriptional regulator YdcR. Mol. Cell. Proteomics, 16, 1683-1693. \r
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Liu Y, Yu K, Zhou F, Ding T, Yang Y, Hu M, Liu X. (2017) Quantitative proteomics charts the landscape of Salmonella carbon metabolism within host epithelial cells. J. Proteome Res., 16, 788-797. 8. \r
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Zhou Y, Huang C, Yin L, Wan M, Wang X, Li L, Liu Y, Wang Z, Fu P, Zhang N, Chen S, Liu X, Shao F, Zhu Y. (2017) Nε-Fatty acylation of Rho GTPases by a MARTX toxin effector. Science, 358, 528-531. \r
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Qiu J, Sheedlo MJ, Yu K, Tan Y, Nakayasu ES, Das C, Liu X, Luo ZQ. (2016) Ubiquitination independent of E1 and E2 enzymes by bacterial effectors. Nature, 533, 120-124.