个人简历

1975年毕业于北京医科大学药学院，留校任教，从事有机化学、生物有机化学、药物化学的教学和科研工作。1990年至1994年，在英国Newcastle－Cambridge大学化学与生物化学学院主修生物有机和药物化学，获理学博士学位。1994年至1997年，在英国Newcastle和美国Princetone大学，做博士后研究工作，从事抗病毒和抗肿瘤药物的研究。1997年10月至现在，任北京大学药学院化学生物学系副教授、教授、博士生导师。1999年至2004年任北京大学药学院副院长，2004年至2005年任北京大学药学院常务副院长，2005年1月起任北京大学药学院院长。主要从事蛋氨酸合成酶酶催化机理的研究，基于新靶点的抗肿瘤药物设计、合成与生物活性研究，抗HIV药物的设计、合成与构效关系研究，中枢神经保护剂的设计、合成与生物活性研究。 任教育部高等学校药学类教执委副主任委员，国务院学位委员会学科评议组药学组成员，教育部药品类高职高专教执委副主任委员，全国高等药学研究会副理事长，北京药学会常务理事，北京药师协会副会长，中国医药教育协会副会长，中国药学（英文版）副主编，药物化学、中国药学年鉴编委，国家科学技术奖评审专家，首都医科大学、新疆石河子大学、海南医学院客座教授。

研究领域

1. 蛋氨酸合成酶酶催化机理的研究。 2. 基于新靶点的抗肿瘤药物设计、合成与生物活性研究。 3. 抗HIV药物的设计、合成与构效关系研究。 4. 中枢神经保护剂的设计、合成与生物活性研究。

近期论文

1. Xiaowei Wang, Qinghua Lou, Ying Guo, Yang Xu, Zhili Zhang and Junyi Liu*，The design and synthesis of 9-phenylcyclohepta[d] pyrimidine-2, 4-dione derivatives as potent non- nucleoside inhibitors of HIV reverse transcriptase. Organic & Biomolecular Chemistry 2006, 4, 3252–3258 2. Yanli Chen, Ying Guo, Hua Yang, Xiaowei Wang and Junyi Liu*, Synthesis of l-(Alkoxymethyl)-5-benzyl-6-methyluracil as Potential Non-nucleoside HIV-1 RT Inhibitors Synthetic Communications 2006, 36: 2913–2920 3. Xiaowei Wang , Yanli Chen ; Ying Guo ; Amin Li ; Xiaoyan Mab; Junyi Liu*, Synthesis of 1-(Alkyl)-5-Dimethylamino-6-Phenethyluracils as Potent Non- nucleoside HIV-1 RT Inhibitors, Synthetic Communications 2007, 37: 2421–2431 4. Xiao Lu, Yanli Chen, Ying Guo, Zhenming Liu, Yawei Shi, Yang Xu, Xiaowei Wang and Junyi Liu*, The Design and Synthesis of N-1 alkylated 5-aminoaryalkyl substituted 6-methyluracils as potential non-nucleoside HIV-1 RT Inhibitors Bioorganic Medicinal Chemistry 2007, 15; 7399–7407 5. Xiaowei Wang , Yanli Chen ; Ying Guo ; Amin Li ; Xiaoyan Mab; Junyi Liu*, Synthesis of 1-(Alkyl)-5-Dimethylamino-6-Phenethyluracils as Potent Non- nucleoside HIV-1 RT Inhibitors Synthetic Communications 2007, 37; 2421-2431 6. Xiaowei Wang, Yu Gao, Yang Xu, Li Li, Zhili Zhang, Junyi Liu*, An efficient preparation of a photolabile agent MNI-glu by regioselective nitration of 4-methoxyindoline derivative Synthetic Communications 2009, 39(22); 4030-4038 7. Libo Gao ; Shigan Fu; Hui Li; Xiaowei Wang; Junyi Liu ;Han Liu; Liyuan Guo; Xinhua Liu; Mengsen Li; Michael A. McNutt; Gang Li, Pyrimidone derivative inhibits simian immunodeficiency virus-induced apoptosis of CEM x174 cells, Cell Biology International 2009, 33; 207-216 8. Zhili Zhang, Zhijian Cheng, Xiaoyan Ma, Xiaowei Wang, Junyi Liu*, A facile alternative synthesis of 1-alkyl-5-alkyl amino-6-phenethyl uracils, Synthetic Communications 2009, 39: 2310–2316 9. Jie Liu, Weidong Liu, Zhili Zhang, Zhijian Cheng, Xiaoyan Ma,Xiaowei Wang, and Junyi Liu* Synthesis of 1-Amino-6,7-dihydro-7-(hydroxymethyl)-4-nitro-pyrrolo[1,2-f] pyrimidin-3- (5H)-one from 2-Amino-6-methylpyrimidin-3-one Synthetic Communications 2009, 39: 2244–2249 10. Zhili Zhang, Jie Liu, Weidong Liu, Xiaowei Wang, hijian Cheng, and Junyi Liu* Synthesis of 2-Amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8–tetrahydropyrido[3,2-d] pyrimidine from 2-Amino-4-hydroxyl-6-methylpyrimidine Journal of Heterocyclic Chemistry 2009, 46; 1151-1153 11. Zhili Zhang, Jun Wu, Fuxiang Ran , Ying Guo, Ran Tian, Shouxin Zhou, Xiaowei Wang, Zhenming Liu, Liangren Zhang, Jingrong Cui, Junyi Liu*, Novel 8-deaza-5,6,7,8-tetrahydro aminopterin derivatives as dihydrofolate inhibitor: Design, synthesis and antifolate activity, European Journal of Medicinal Chemistry 2009, 44; 764-771 12. Hua Qin, Jianfang Zhang, Chang Liu, Ying Guo, Siwei Zhang, Zhili Zhang, Xiaowei Wang, Liangren Zhang, Junyi Liu*, Synthesis and biological evaluation of novel 2-arylalkylthio -4-amino-6-benzyl pyrimidines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors, Bioorganic Medicinal Chemistry Letter 2010. 20; 3003-3005 13. Hua Qin , Chang Liu , Ying Guo , Ruiping Wang , Jianfang Zhang , Liying Ma, Zhili Zhang , Xiaowei Wang, Yuxin Cui , Junyi Liu*, Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors Bioorganic & Medicinal Chemistry 2010, 18, 3231-3237 14. Wenjing Chen, Wujie Li, Xiaomei Ling, Xiaowei Wang, Junyi Liu*, Study on the interaction between HIV reverse transcriptase and its non-nucleoside inhibitor nevirapine by capillary electrophoresis. Journal of Chromatography B, 2010, 878; 1714–1717