个人简历

多年来一直从事仪器分析和药物分析的教学和科研工作，主编了《高等仪器分析实验与技术》，并担任药物分析杂志编委、中国药学会药物分析委员会委员等。对色谱联用技术和高效毛细管电泳在医药领域中的应用做了大量的研究工作，主要研究工作有：（1）药物代谢动力学及代谢组学研究；（2）生物分子之间的相互作用及生物分子与药物分子之间相互作用研究；（3）天然产物及合成化合物中活性成分的定性定量筛选研究；（4）新药质量标准及稳定性研究；（5）手性药物拆分测定；（6）体内、体外脂肪酸含量测定等。发表相关学术论文70余篇。

研究领域

1、药物分析新技术和新方法研究及其在生物医药领域中的应用研究:采用毛细管电泳方法研究分子间相互作用研究，如生物大分子和小分子、生物大分子与生物大分子相互作用；手性物质的拆分及与生物大分子相互作用研究；毛细管色谱柱固定化技术研究（固定蛋白、细胞等）及在药物研究中的应用。 2、药物代谢动力学及代谢组学研究:采用现代仪器和色谱联用技术，进行药物体内的生物转化、血药浓度-时间曲线、吸收、分布、排泄、与血浆蛋白结合、对药物代谢酶活性影响和药物-药物相互作用及代谢组学研究等。 3、新药质量标准及稳定性研究:创新药物质量标准建立和稳定性研究。

近期论文

1. Jing Li, Wensi Lin, Weiwei Lin, Peng Xu, Jianmei Zhang, Haisong Yang, Xiaomei Ling？, Metabolic profiling study on potential toxicity and immunotoxicity-biomarker discovery in rats treated with cyclophosphamide using HPLC-ESI-IT-TOF-MS，Biomedical Chromatography, 2015, 29(5): 768-776 2. Zhongjie Li, Yiran Zhao, Weiwei Li, Xiaobo Hu, MinYe, Xiaodan Zhang, Xiaomei Ling*，Rapid screening and identification of active ingredients in licoriceextract interacting with V3 loop region of HIV-1 gp120 using ACE andCE-MS，Journal of Pharmaceutical and Biomedical Analysis, Journal of Pharmaceutical and Biomedical Analysis, 2015, 111: 28–35 3. Peng Xu, MinLi, Yanping Βai, WeiLu, Xiaomei Ling*,WeidongLi, The effects of piracetam on heroin-induced CPP and neuronal apoptosis in rats，Drug and Alcohol Dependence, 2015.150: 141-146 4. Zhongjie Li, Li Li, Xiaowei Wang, Junyi Liu, Xiaomei Ling*，Interactions of carrageenan or its degradation with R15K by affinity capillary electrophoresis，Journal of Chinese Pharmaceutical Sciences，2015,24（6）: 400-404 5. Peng Xu, Yanping Βai, Haisong Yang, Jing Li, Wei Lu, Xiaomei Ling*，High-performance liquid chromatography with fluorescence detection method for simultaneous quantitation of monoamine neurotransmitters and their metabolites in subregions of rat brain, Journal of Chinese Pharmaceutical Sciences，2015,24(7):458-466 6. Yiran Zhao, Zhongjie Li, Yong Jiang, Xiaodan Zhang,Xiaomei Ling*，Rapid screening of anti-HIV ingredients in Artemisia rupestris L. extracts interacting with V3 loop region of HIV-1 gp120 and reverse transcriptase by affinity capillary electrophoresis and capillary zone electrophoresis，Journal of Chinese Pharmaceutical Sciences，2015,24(6):625-629 7. Lu Yang, Pazilaiti.Yakufu, Meina Li, Xiaomei Ling*, Zhongjie Li, Ying Wang,Study on Interactions between Ligands (Compound A/22) and CCR4, ML40, 3 Extracellular Loops by ACE and CZE，Journal of Chinese Pharmaceutical Sciences，2014，23(3)186-189 8. Meina Li,·Lei Lei,·Linghan Jia, Xiaomei Ling*, Jianmei Zhang, Yiran Zhao, Kewei Wang, Quantitative evaluation of interactions between Kv4.3 N-terminus and its auxilary subunit KchIPs by affinity capillary electrophoresis, Analytical Biochemistry, 2014,449:99-105 9. Haisong Yang, Wensi Lin, Jianmei Zhang, Weiwei Lin, Peng Xu, Jing Li, Xiaomei Ling*，Urine metabonomics analysis of the toxic effects of TM208 in rats by HPLC-IT-TOF/MS, Journal of Chromatography B, 2014, 959: 49-54 10.Jing Li, Weiwei Lin, Dai Li, Yingfang Ao, Haisong Yang, Xiaomei Ling*A validated HPLC method for the determination of cefazolin sodium level in rabbit synovial fluid, Journal of Chinese Pharmaceutical Sciences 2014,23(9):649-653 11.Pazilaiti.Yakufu, Hui Qi, Xiaomei Ling*, Wenjing Chen, Ying Wang，CCR4 Expressing Cell Cultured Adherently on a Capillary Wall as the Stationary Phase for Ligand Screening by ACE, Electrophoresis, 2013,34（4）:531-540 12.Wensi Lin, Jianmei zhang, Xiaomei Ling*, Ning Yu, Jing Li, Haisong yang, Runtao Li, Jingrong Cui, Evaluation of the effect of TM208 on the activity of five cytochrome P450 enzymes using on-line solid-phase extraction HPLC-DAD: A cocktail approach, Journal of Chromatography B, 2013, 923-924: 29-36. 13.Meina Li, Qing Wang, Xiaomei Ling*, Lu Yang, Zhongjie Li, Min Ye, Ying Wang,Interactions between N-terminal extracellular tail of CCR4 and natural products of licorice using capillary electrophoresis, Chromatographia, 2013, 76(13-14): 811-819. 14.Wen-Jing Chen, Pazilaiti.Yakufu, Xiao-Mei Ling*, Hui Qi, Jun-Hai Xiao, Ying Wang, N-terminal extracellular tail of CC chemokine receptor 4 (ML40) immobilized on capillary column to study the interactions between ML40 and its potential ligands，Analytical Biochemistry, 2012,423(1): 1-6 15.Jianmei Zhang, Wensi Lin, Xiaona Li, Ning Yu, Xiaomei Ling*, Ge Fu, Runtao Li, Jingrong Cui, Determination of 4-methylpiperaine-1-carbodithioc acid 3-cyano-3, 3-diphenylpropyl ester hydrochloride in Rats’ Plasma by Online-SPE-HPLC-DAD: Application to a Pharmacokinetic Study, Journal of Separation Science, 2012, 35(5-6): 721-725