杜晓娟
近期热点
资料介绍
个人简历
主要工作简历2011.08-今:北京大学基础医学院,细胞生物学系,教授2001.10-2011.07:北京大学基础医学院,细胞生物学系,副教授1995.10-1998.06:首都儿科研究所,生化与免疫,副研究员1993.10-1995.09:首都儿科研究所,生化与免疫,助理研究员1991.09-1993.09:首都儿科研究所,生化与免疫,实习研究员教育经历1998.07-2001.07:德国Freiburg大学,生物学,博士1988.09-1991.07:首都儿科研究所,生化与免疫,硕士1982.09-1988.07:北京医科大学,临床医学,本科研究领域
细胞核仁蛋白在肿瘤发生中的作用机制及在肿瘤治疗中的作用近期论文
1. Jingyi Zhang#, Pengwei Ren#, Da Xu#, Xiaofeng Liu, Zhenzhen Liu, Chunfeng Zhang, Yuan Lia, Lijun Wanga, Xiaojuan Du*and Baocai Xing*. Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc. Cancer Letters. 2018, 440-441(2019) :106-115.2. Xiaofeng Liu, Shiying Cai, Chunfeng Zhang, Zhenzhen Liu, Jianyuan Luo, Baocai Xing* and Xiaojuan Du*. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucl Acids Res., 2018 Oct 12;46(18):9601-9616.3. Tong Zheng, Min Lu, Ting Wang, Chunfeng Zhang, Xiaojuan Du*. NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression. BBA Mol Cell Res.2018, 12(1865) : 1869-1877.4. Huijiao Liu, Jiangnan Wang, Yun Liu, Min Lu, Lelin Hu, Chunfeng Zhang, Baocai Xing and Xiaojuan Du*. Human U3 protein14a is a novel type ubiquitin ligase that binds RB and promotes RB degradation depending on a Leucine-rich region. BBA Mol Cell Res., 2018, 1865 :1611-1620.5. Yuqin Tan, Jiaojiao Zheng, Xiaofeng Liu, Min Lu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du*, Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma, Biochem. Biophys. Res. Commun.2018, 499: 1032-1038.6. Ma T, Lu C, Guo Y, Zhang C, Du X*. Human U3 protein 14a plays an anti-apoptotic role in cancer cells. Biol. Chem.2017, 398(11):1247-1257.7. Cai S, Liu X, Zhang C, Xing B, Du X*. Autoacetylation of NAT10 is critical for its function in rRNA transcription activation. Biochem. Biophys. Res. Commun.2017, 483: 624-629.8. Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, Deng H, Luo J, Ke Y, Du X*. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016, 17(3): 349-366.9. Wang Y, Zheng Z, Zhang J, Wang Y, Kong R, Liu J, Zhang Y, Deng H, Du X*, Ke Y*. A novel retinoblastoma protein (RB) E3 ubiquitin Ligase (NRBE3) Promotes RB degradation and is transcriptionally regulated by E2F1 transcription factor. J Biol Chem. 2015,290(47):28200-13.10. Jin KM, Liu FF, Gu J, Du XJ*andXing BC*. N-WASP is highly expressed in hepatocellular carcinoma and associated with poor prognosis. Surgery.2013, 153: 518-25.11. Wu J, Zhang Y, Wang, Y, Kong R, Hu L, Schuele R,Du X*and Ke Y*. Transcription repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits. PLoS ONE.2012, 7(2): e31692.12. Song JM, Lu M, Liu FF, Du XJ*and Xing BC*. AIB1 as an independent prognostic marker in hepatocellular carcinoma after Hepatic Resection. J Gastrointest Surg.2012, 16: 356-360.13. Kong R, Zhang L, Hu L, Peng Q, Han W, Du X*and Ke Y*.hALP, A novelt-UTP, activates polymerase I transcription by binding and acetylating the upstream binding factor. J Biol Chem.2011, 286(9): 7139-48.14. Hu L, Wang J, Zhang L, Kong R, Zheng Z, Han W, Du X*and Ke Y*. A small ribosomal subunit (SSU) processome component, the human U three protein 14a binds p53 and promotes p53 degradation. J Biol Chem.2011, 286(4): 3119-28. 相关热点