个人简历

B.S., cum laude in Biology, Tufts University, 1984
Ph.D. in Biochemistry, Brandeis University, 1989
American Cancer Society Postdoctoral Fellow in X-ray Crystallography, Massachusetts Institute of Technology, 1989 and Brandeis University, 1990

近期论文

Lanthanide-tagged proteins--an illuminating partnership.r
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Allen KN, Imperiali B.r
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Curr Opin Chem Biol. 2010 Apr;14(2):247-54. Epub 2010 Jan 25.PMID: 20102793 [PubMed - in process]r
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Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease.r
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Stowe GN, Silhár P, Hixon MS, Silvaggi NR, Allen KN, Moe ST, Jacobson AR, Barbieri JT, Janda KD.r
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Org Lett. 2010 Feb 19;12(4):756-9.PMID: 20092262 [PubMed - indexed for MEDLINE]r
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Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).r
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Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D.r
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Biochemistry. 2010 Feb 16;49(6):1072-81.PMID: 20050615 [PubMed - indexed for MEDLINE]r
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Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) .r
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Nguyen HH, Wang L, Huang H, Peisach E, Dunaway-Mariano D, Allen KN.r
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Biochemistry. 2010 Feb 16;49(6):1082-92.PMID: 20050614 [PubMed - indexed for MEDLINE]r
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Markers of fitness in a successful enzyme superfamily.r
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Allen KN, Dunaway-Mariano D.r
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Curr Opin Struct Biol. 2009 Dec;19(6):658-65. Epub 2009 Nov 2. Review.PMID: 19889535 [PubMed - indexed for MEDLINE]r
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The origin of the electrostatic perturbation in acetoacetate decarboxylase.r
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Ho MC, Ménétret JF, Tsuruta H, Allen KN.r
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Nature. 2009 May 21;459(7245):393-7.PMID: 19458715 [PubMed - indexed for MEDLINE]r
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Analysis of the structural determinants underlying discrimination between substrate and solvent in beta-phosphoglucomutase catalysis.r
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Dai J, Finci L, Zhang C, Lahiri S, Zhang G, Peisach E, Allen KN, Dunaway-Mariano D.r
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Biochemistry. 2009 Mar 10;48(9):1984-95.PMID: 19154134 [PubMed - indexed for MEDLINE]r
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Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members.r
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Lu Z, Wang L, Dunaway-Mariano D, Allen KN.r
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J Biol Chem. 2009 Jan 9;284(2):1224-33. Epub 2008 Nov 5.PMID: 18986982 [PubMed - indexed for MEDLINE]r
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Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).r
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Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D.r
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Chem Biol. 2008 Sep 22;15(9):893-7.PMID: 18804026 [PubMed - indexed for MEDLINE]r
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Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex.r
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Silvaggi NR, Wilson D, Tzipori S, Allen KN.r
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Biochemistry. 2008 May 27;47(21):5736-45. Epub 2008 May 6.PMID: 18457419 [PubMed - indexed for MEDLINE]r
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The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state.r
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Lu Z, Dunaway-Mariano D, Allen KN.
Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5687-92. Epub 2008 Apr 8.PMID: 18398008 [PubMed - indexed for MEDLINE]