个人简历

Ph.D., Stanford University, 1974r
Postdoctoral Associate, University of Illinois, Urbana IL, 1974-1975
Postdoctoral Associate, University of California San Diego, 1975-1978

近期论文

C.A. Doughty, B.F. Bleiman, D.J. Wagner, F.J. Dufort, J.M. Mataraza, M.F. Roberts, and T.C. Chiles, “Receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol-3-kinase signaling in the glycolytic control of growth,” Blood 107, 4458-4465 (2006).r
r
A.C. Faber, F.J. Dufort, D. Blair, D. Wagner, M.F. Roberts, and T.C. Chiles, “Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas,” Biochem. Biopharm. 29, 1561-1566 (2006).r
r
C. Shao, X. Shi, H. Wehbi, C. Zambonelli, J.F. Head, B.A. Seaton, and M.F. Roberts, “Dimer structure of an interfacially impaired phosphatidylinositol-specific phospholipase C,” J. Biol. Chem., 282, 9228-9235 (2007).r
r
D.A. Rodionov, O.V. Kurnasov, B. Stec, Y. Wang, M.F. Roberts, and A. Osterman, “Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol phosphate,” Proc. Natl. Acad. Sci. U.S.A. 104, 4279-4284 (2007).r
r
E. Crouch, B. McDonald, K Smith, M. Roberts, T. Cafarella, B. Seaton, and J. Head, “Critical role of Arg/Lys343 in the species-dependent recognition of phosphatidylinositol by pulmonary surfactant protein D,” Biochemistry 46, 5160-5169 (2007).r
r
K.A. Stieglitz, M.F. Roberts, W. Li, and B. Stec, “Crystal structure of the tetrameric IMPase (TM1415) from the hyperthermophile Thermotoga maritima,” FEBS J. 274, 2461-2469 (2007).r
r
Y.K. Wang, K.A. Stieglitz, M. Bubunenko, D.L. Court, B. Stec, and M.F. Roberts, “The structure of the R184A mutant of the inositol monophosphatase encoded by suhB and implications its functional interactions in E. coli,” J. Biol. Chem. 282, 26989-26996 (2007).r
r
B.F. Bleiman, F.J. Dufort, M.R. Gumina, D. Blair, D.J. Wagner, M.F. Roberts, and T.C. Chiles, “Interleukin-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism,” J. Immunol. 179, 4953-4957 (2007).r
r
J.B. Klauda, M.F. Roberts, A.G. Redfield, B.R. Brooks, and R.W. Pastor, “Rotation of lipids in membranes: MD simulation, 31P spin-lattice relaxation, and rigid-body dynamics,” Biophys. J. 94, 3074-3083 (2008).r
r
S. Guo, X. Zhang, B. A. Seaton, and M. F. Roberts, “Role of helix B residues in interfacial activation of a bacterial PI-PLC,” Biochemistry 47, 4201-4210 (2008).r
r
Y.K. Wang, W. Chen, D. Blair, M. Pu, Y. Xu, S.J. Miller, A.G. Redfield, T.C. Chiles, and M. F. Roberts, “Insights into the structural specificity of the cytotoxicity of 3-deoxy-phosphatidylinositols,” J. Am. Chem. Soc. 130, 7746-7755 (2008).r
r
V.N. Sivanandam, J. Cai, A.G. Redfield, and M.F. Roberts, “Phosphatidylcholine “wobble” in vesicles assessed by high-resolution 13C field cycling NMR spectroscopy,” J. Am. Chem. Soc. 131, 3420-3421 (2009).r
r
W. Chen, H. Goldfine, B. Ananthanarayanan, W. Cho, and M.F. Roberts, “Listeria monocytogenes phosphatidylinositol-specific phospholipase C: Kinetic activation and homing in on different interfaces,” Biochemistry 48, 3578-3592 (2009).r
r
M.F. Roberts, U. Mohanty, and A.G. Redfield, “Phospholipid reorientation at the lipid/water interface measured by high resolution field cycling 31P NMR spectroscopy,” Biophys. J. 97, 132-141 (2009).r
r
C.M. Longo, Y. Wei, M.F. Roberts, and S.J. Miller, “Asymmetric syntheses of L,L- and L,D-di-myo-inositol-1,1’-phosphate and heir behavior as stabilizers of enzyme activity at extreme temperatures, Angew. Chem. Int. Ed. 48, 4158-4161 (2009).r
r
X. Shi, C. Shao, X. Zhang, C. Zambonelli, A.G. Redfield, J.F. Head, B.A. Seaton, and M.F. Roberts, “Modulation of Bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface,” J. Biol. Chem. 284, 15607-15618 (2009).r
r
M. Pu, X. Fang, A. Gershenson, A.G. Redfield, and M.F. Roberts, “Correlation of vesicle binding and phospholipid dynamics with phospholipase C activity: Insights into phosphatidylcholine activation and surface dilution inhibition,” J. Biol. Chem. 284, 16099-16107 (2009).r
r
M. Pu, M.F. Roberts, and A. Gershenson, “Fluorescence correlation spectroscopy of phosphatidylinositol-specific phospholipase C monitors the interplay of substrate and activator lipid binding,” Biochemistry 48, 6835-6845 (2009).r
r
M. Pu, J. Feng, A.G. Redfield, and M.F. Roberts, “Enzymology with a spin-labeled phospholipase C: soluble substrate binding by 31P NMR from 0.005 to 11.7 Tesla,” Biochemistry 48, 8282-88284 (2009).
Z. Li, K.A. Stieglitz, A.L. Shrout, Y. Wei, R.M. Weis, B. Stec, and M.F. Roberts, “Mobile loop mutations in an archaeal inositol monophosphatase: modulating three-metal ion assisted catalysis and lithium inhibition,” Prot. Sci. 19, 309-318 (2009).