个人简历

EDUCATION\r
1994-1998 B.Sc. in Chemistry with first-class honors at National University of Singapore.\r
1998-2000 M.Sc. in Chemistry at National University of Singapore. Supervisor: Teck-Peng Loh\r
2000-2005 Ph.D. in Organic Chemistry at Massachusetts Institute of Technology. Supervisor: Gregory C. Fu\r
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PROFESSIONAL EXPERIENCE\r
2005-2008 Postdoctoral researcher at Yale University and University of Illinois at Urbana. Supervisor: John F. Hartwig\r
2008-2013 Singapore National Research Foundation Fellow (joint appointment)\r
2008-2019 Assistant Professor and Senior Research Scientist at Nanyang Technological University\r
2019 Associated Professor at Peking University Shenzhen Graduate School\r
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HONORS AND AWARDS\r
2008 Singapore National Research Foundation fellowship\r
2011-14 Asian Core Program Lectureship Award\r
(2011 Malaysia, 2012 Taiwan, 2013 Japan and 2014 China)\r
2012 Thieme Chemistry Journals Award\r
2015 SPMS Young Researcher Award, Nanyang Technological University\r
2013, 2017 GSK-EDB Green and Sustainable Manufacturing Award\r
2019 Bayer Investigator Award

研究领域

""My research focuses on transition metal catalysis, mechanistic studies and application to stereoselective synthesis of chiral drugs. An emphasis is placed on asymmetric catalytic processes. Chiral drugs contribute to one third of modern medicines today. Nowadays almost all of newly approved small-molecule drugs are made in optically pure forms, so as to avoid toxicity caused by unwanted isomers.\r
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Other research interest includes: 1) Application of photocatalysis and reactive radical species in metal catalysis. 2) Replacement of expensive noble metals with Earth-abundant late 3d metals. 3) Stereoselective formation of strained rings, deuterated and fluorinated compounds, which are becoming increasingly important in medicines.\r
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Examples of ongoing projects include 1) Heck reaction, 2) arylation of carbonyl compounds, 3) palladium radical catalysis, 4) nickel-catalyzed transfer hydrogenation and 5) copper-catalyzed addition of air-stable organoboron reagents. In particular, asymmetric hydrogenation has become an important tool for large-scale synthesis of chiral key intermediates in industry, but hydrogenation catalysts rely heavily on very expensive, rare metals, such as rhodium, iridium and ruthenium. It poses a severe problem of sustainability in pharmaceutical manufacturing.\r
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I also seek intellectual contribution to transition metal catalysis at a fundamental level: 1) New ways of bond activation, for example, using classical hydrogen bonding for soft ionization of arylpalladium halides in asymmetric Heck reaction. 2) New ways of bond formation in metal catalysis, for example, discovery of a new elementary step of 1,4-insertion in copper-catalyzed asymmetric addition. 3) New means of chirality transfer from catalysts to products, for example, employing weak CH/O hydrogen bonding in palladium-catalyzed asymmetric coupling of enolates.""""

近期论文

Enantioselective Synthesis of Chiral Carboxylic Acids from Alkynes and Formic Acid by Nickel-Catalyzed Cascade. Reactions: Facile Synthesis of Profens. Peng Yang, Yaxin Sun, Kaiyue Fu, Li Zhang, Guang Yang, Jieyu Yue, Yu Ma,* Jianrong Steve Zhou,* Bo Tang* Angew. Chem., Int. Ed. 2021, accepted. DOI: 10.1002/anie.202111778\r
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Nickel-Catalyzed Enantioselective Umpolung Hydrogenation for Stereoselective Synthesis of b-Amido Esters. Jianrong Steve Zhou,* Siyu Guo, Xiaohu Zhao and Yonggui Robin Chi. Chem. Commun. 2021, 57, 11501-11504. DOI: 10.1039/D1CC05257H. Published on Oct 6, 2021\r
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Asymmetric Domino Heck Arylation and Alkylation of Nonconjugated Dienes: Double C–F···Sodium Attractive Noncovalent Interaction. Daoyong Zhu, Wenqiang Xu, Maoping Pu, Yun-Dong Wu, Yonggui Robin Chi and Jianrong Steve Zhou* Org. Lett. 2021, 23(18), 7064–7068. DOI: 10.1021/acs.orglett.1c02457 Published on Sept 1, 2021. Highlighted by ChemBeanGo in September 2021\r
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Nickel-Catalyzed Heck Reaction of Cycloalkenes using Aryl Sulfonates and Pivalates. Jianrong Steve Zhou,* Xiaolei Huang, Shenghan Teng and Yonggui Robin Chi. Chem. Commun. 2021, 57, 3933-3936. DOI: 10.1039/D1CC00634G Published on March 12, 2021\r
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Enantioselective Three-Component Coupling of Heteroarenes, Cycloalkenes and Propargylic Acetates. Shenghan Teng, Yonggui Robin Chi and Jianrong Steve Zhou* Angew. Chem., Int. Ed.2021, 60(9), 4491-1195. DOI: 10.1002/anie.202014781 First published on 1 Dec 2020. Published on Feb 23, 2021. Highlighted by x-mol in Dec 2020 \r
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Enantioselective Intermolecular Heck and Reductive Heck Reactions of Aryl Triflates, Mesylates and Tosylates Catalyzed by Nickel. Xiaolei Huang, Shenghan Teng, Yonggui Robin Chi, Wenqiang Xu, Maoping Pu, Yun-Dong Wu and Jianrong Steve Zhou* (WX, MP and TDW contributed DFT calculation) Angew. Chem., Int. Ed. 2021, 60(6), 2828-2832. DOI: 10.1002/anie.202011036 Published on 2 Nov 2020. Highlighted by chem-station in Nov 2020 \r
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Nickel-catalyzed C-alkylation of thioamide, amides and esters by primary alcohols through a hydrogen autotransfer strategy. Peng Yang,* Xiuhua Wang, Yu Ma, Li Zhang, Yaxin Sun, Jieyu Yue, Kaiyue Fu, Jianrong Steve Zhou* and Bo Tang* Chem. Commun. 2020, 56, 14083-14086 DOI: 10.1039/D0CC06468H. First published on 15 Oct 2020\r
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Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes to Access Conformationally Restricted Aza[3.1.0]bicycles. Xiaolei Huang, Minh Hieu Nguyen, Maoping Pu, Luoqiang Zhang, Yonggui Robin Chi, Yun-Dong Wu and Jianrong Steve Zhou* (MP and TDW contributed DFT calculation) Angew. Chem., Int. Ed. 2020, 59(27), 10814-10818. DOI: 10.1002/anie.202000859 First published on Mar 26, 2020. Highlighted in Synfacts 2020, 16(09), 1078 and Organic Chemistry Portal in Dec 2020 \