个人简历

Born and raised in Beijing, Peng Zou was drawn to science as early as in high school. He was a gold medalist in Chinese Chemistry Olympiad and a silver medalist in Chinese Mathematics Olympiad in 2003. Peng attended Peking University from 2003 to 2007 and received his B.S. degree in Chemistry, with a double major in Physics. At PKU, Peng did his undergraduate research in Prof. Bin Xia's group, where he learnt to use nuclear magnetic resonance spectroscopy to solve the three-dimensional structure of proteins. This experience has sparked his interest in applying physical and chemical tools to understand biological functions.\r
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After graduation, Peng moved to the U.S. and joined Prof. Alice Ting’s lab at Massachusetts Institute of Technology as a graduate student, where he worked on protein engineering, proteomics, and super-resolution imaging. His thesis led to the development of enzyme-based reporters for mapping proteome and imaging proteins in living cells. Peng obtained his Ph.D. in Biological Chemistry from MIT in 2012. He then worked with Prof. Adam Cohen at Harvard University as a postdoc fellow. His research was focused on developing fluorescent probes for imaging neural activity and applying these tools to study human disease model (e.g. amyotrophic lateral sclerosis) and animal model (e.g. zebrafish brain). These research projects have exposed Peng to a diverse array of disciplines, from protein engineering and cell biology to microscopy and programming.\r
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Peng joined Peking University in 2015 as an Assistant Professor in the College of Chemistry and Molecular Engineering. He was also appointed as a Principal Investigator at the PKU-Tsinghua Center for Life Sciences and the PKU-IDG/McGovern Institute for Brain Research. His lab focuses on developing chemistry-enabled tools for mapping neuronal signaling with high spatial and temporal resolutions. Peng was selected as one of C&EN's Talented 12 in 2019, and was appointed as a Young Investigator of Chinese Institute for Brain Research in 2020. He was the recipient of OKeanos-CAPA Young Investigator Award at the Chemical and Biology Interface and Bayer Investigtor Award in 2020. In 2021, Peng was promoted to Associate Professor with tenure at Peking University.

研究领域

""本课题组致力于发展新型化学探针技术，为神经科学的研究提供新工具、新方法。我们一方面综合运用蛋白质工程、分子生物学和有机合成等手段创造新的功能分子，例如各类荧光探针、具有生物分子标记功能的酶及活性底物等；另一方面，结合光学、质谱、高通量测序等仪器技术，利用这些工具观测神经细胞的结构与活性，并通过数学建模对数据进行定量分析。目前的研究方向包括：（1）发展可遗传编码的荧光膜电位探针，实现对神经细胞动作电位的高时空分辨观测；（2）研究与神经退行性疾病相关的RNA颗粒的结构与功能；（3）发展蛋白质标记技术，研究参与记忆形成过程的局部蛋白质合成途径。""""

近期论文

Bringing together the best of chemistry and biology: hybrid indicators for imaging neuronal membrane potential Liu, S.#, Yang, J.# and Zou, P.* (2021) J. Neurosci. Methods 363, 109348. DOI: 10.1016/j.jneumeth.2021.109348\r
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APEX2-based proximity labeling of Atox1 identifies CRIP2 as a nuclear copper-binding protein that regulates autophagy activation Chen, L., Li, N., Zhang, M., Sun, M., Bian, J., Yang, B., Li, Z., Wang, J., Li, F., Shi, X., Wang, Y., Yuan, F., Zou, P., Shan, C. and Wang, J.* (2021) Angew. Chem. Int. Ed. Engl. 60, 25346-25355. DOI: 10.1002/anie.202108961\r
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Targeting cytokinesis bridge proteins to kill high-CIN type tumors Xie, B., Liang, X., Yue, W., Ma, J., Li, X., Zhang, N., Wang, P., Liu, C., Shi, X., Qiao, J., Zou, P. and Li, M.* (2021). Fundamental Research 1, 752-766. DOI: 10.1016/j.fmre.2021.08.015\r
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Spatiotemporally resolved subcellular phosphoproteomics Liu, Y.#, Zeng, R.#, Wang, R., Weng, Y., Wang, R., Zou, P.* and Chen, P. R.* (2021). Proc. Natl. Acad. Sci. U. S. A. 118, e2025299118. DOI: 10.1073/pnas.2025299118\r
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Inhibition of α-synuclein accumulation improves neuronal apoptosis and delayed postoperative cognitive recovery in aged mice Li, Y., Yuan, Y., Li, Y., Han, D., Liu, T., Yang, N., Mi, X., Hong, J., Liu, K., Song, Y., He, J., Zhou, Y., Han, Y., Shi, C., Yu, S., Zou, P., Guo, X.* and Li, Z.* (2021). Oxid. Med. Cell Longev. 2021, 5572899. DOI: 10.1155/2021/5572899\r
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A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons Liu, S.#, Lin, C.#, Xu, Y.#, Luo, H., Peng, L., Zeng, X., Zheng, H., Chen, P. R.* and Zou, P.* (2021). Nat. Chem. 13, 472-479. DOI: 10.1038/s41557-021-00641-1\r
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Spatially resolved cell polarity proteomics of a human epiblast model Wang, S., Lin, C.-W., Carleton, A. E., Cortez, C. L., Johnson, C., Taniguchi, L. E., Sekulovski, N., Townshend, R. F., Basrur, V., Nesvizhskii, A. I., Zou, P., Fu, J.*, Gumucio, D. L.*, Duncan, M. C.* and Taniguchi, K.* (2021). Sci. Adv. 7, eabd8407. DOI: 10.1126/sciadv.abd8407\r
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Spatiotemporal profiling of cytosolic signaling complexes in living cells by selective proximity proteomics Ke, M., Yuan, X., He, A., Yu, P., Chen, W., Shi, Y., Hunter, T., Zou, P. and Tian, R.* (2021). Nat. Commun. 12, 71. DOI: 10.1038/s41467-020-20367-x\r
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The evolving capabilities of enzyme-mediated proximity labeling Zhou, Y. and Zou, P.* (2021). Curr. Opin. Chem. Biol. 60, 30-38. DOI: 10.1016/j.cbpa.2020.06.013\r
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COPII mitigates ER stress by promoting formation of ER whorls Xu, F., Du, W., Zou, Q., Wang, Y., Zhang, X., Xing, X., Li, Y., Zhang, D., Wang, H., Zhang, W., Hu, X., Liu, X., Liu, X., Zhang, S., Yu, J., Fang, J., Li, F., Zhou, Y., Yue, T., Mi, N., Deng, H., Zou, P., Chen, X., Yang, X.* and Yu, L.* (2021). Cell Res. 31, 141-156. DOI: 10.1038/s41422-020-00416-2\r
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Chromophore-assisted proximity labeling of DNA reveals chromosomal organization in living cells Ding, T.#, Zhu, L.#, Fang, Y., Liu, Y., Tang, W. and Zou, P.* (2020). Angew. Chem. Int. Ed. Engl. 59, 22933-22937. DOI: 10.1002/anie.202005486\r
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Protocol for proximity-dependent proteomic profiling in yeast cells by APEX and Alk-Ph probe Li, Y., Liu, K., Zhou, Y., Yang, J.* and Zou, P.* (2020). STAR Protoc. 1, 100137. DOI: 10.1016/j.xpro.2020.100137\r
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A clickable APEX probe for proximity-dependent proteomic profiling in yeast Li, Y., Tian, C., Liu, K., Zhou, Y., Yang, J.* and Zou, P.* (2020). Cell Chem. Biol. 27, 858-865. DOI: 10.1016/j.chembiol.2020.05.006\r
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Exosome alpha-synuclein release in plasma may be associated with postoperative delirium in hip fracture patients Yuan, Y.#, Li, Z.#, Yang, N.#, Han, Y., Ji, X., Han, D., Wang, X., Li, Y., Liu, T., Yuan, F., He, J., Liu, Y., Ni, C., Zou, P., Wang, G.*, Guo, X.* and Zhou, Y.* (2020). Front Aging Neurosci. 12, 67. DOI: 10.3389/fnagi.2020.00067\r
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Genome-wide mapping of oxidative DNA damage via engineering of 8-oxoguanine DNA glycosylase Fang, Y. and Zou, P.* (2020). Biochemistry 59, 85-89. DOI: 10.1021/acs.biochem.9b00782\r
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Imaging neuronal activity with fast and sensitive red-shifted electrochromic FRET indicators Xu, Y.#, Deng, M.#, Zhang, S.#, Yang, J.#, Peng, L., Chu, J.* and Zou, P.* (2019). ACS Chem. Neurosci. 10, 4768-4775. DOI: 10.1021/acschemneuro.9b00501\r
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Dynamic modifications of biomacromolecules: mechanism and chemical interventions Wang, C., Zou, P., Yang, C., Liu, L., Cheng, L., He, X., Zhang, L., Zhang, Y., Jiang, H.* and Chen, P.R.* (2019). Sci. China Life Sci. 62, 1459-1471. DOI: 10.1007/s11427-019-9823-1\r
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Mapping spatial transcriptome with light-activated proximity-dependent RNA labeling Wang, P.#, Tang, W.#, Li, Z.#, Zou, Z., Zhou, Y., Li, R., Xiong, T., Wang, J.* and Zou, P.* (2019). Nat. Chem. Biol. 15, 1110-1119. DOI: 10.1038/s41589-019-0368-5\r
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MRGPRX4 is a bile acid receptor for human cholestatic itch Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., Peng, L., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Zou, P., Lei, X., Luo, W.* and Li, Y.* (2019). Elife 8, e48431. DOI: 10.7554/eLife.48431\r
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Expanding APEX2 substrates for proximity-dependent labeling of nucleic acids and proteins in living cells Zhou, Y.#, Wang, G.#, Wang, P., Li, Z., Yue, T., Wang, J. and Zou, P.* (2019). Angew. Chem. Int. Ed. Engl. 58, 11763-11767. DOI: 10.1002/anie.201905949\r