个人简历

1990年、1993年、2002年先后获北京大学理学学士、硕士和博士学位。1997-1998年，荷兰阿姆斯特丹大学环境与毒理化学系访问学者；1998年，荷兰能源研究机构环境分析部访问学者。

研究领域

"""""1、功能化分子识别新材料的设计合成：\r
我们为不同的检测目标体系“量身定做”特异性分子识别材料，利用化学的手段模拟生物分子间特异性的识别作用，采用分子印迹的原理设计和合成“人工受体”亲和吸附材料，既可以用于复杂体系的选择性分离、纯化和富集，也可以作为识别元件与信号转化元件相耦合，实现识别与传感一体化。\r
为了能更好地模拟生物分子间的非共价、可逆的多位点协同作用，我们也同时搭建了完整的分子生物学实验平台，可以根据不同需求构建表达重组蛋白和制备单克隆及多克隆抗体，进而获取各种生物分子的核心识别片段，为深入开展分子间识别作用机理研究提供全面的基础。\r
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2、新型光学生物传感器的构建开发：\r
我们系统开展均相体系中光学生物传感检测方法的研究。一方面开发和利用小分子-蛋白-核酸间的相互作用特点构建新的分子识别体系，同时引入新型的纳米功能材料，改进和提高方法的灵敏度、稳定性、时间和空间分辨率及生物相容性，为原位、实时检测目标分子提供可靠的方法。\r
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3、微流控芯片上的生化分析：\r
对于生物体内关键物质产生和变化的动态观测，依赖于微环境下扰动少、响应快的检测手段，我们利用微流控芯片平台研究在微环境下的生化反应特点和动态检测技术，为了解细胞表面和细胞内活性物质的分布、转化规律提供有效的方法。"

近期论文

Xianjin Xiao, Tongbo Wu, Lei Xu, Wei Chen and Meiping Zhao*, A branch-migration based fluorescent probe for straightforward, sensitive and specific discrimination of DNA mutations, Nucleic Acids Research, 2017, DOI: 10.1093/nar/gkx117.\r
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Junqiu Zhai, Yibin Liu, Shan Huang, Simin Fang and Meiping Zhao*, A specific DNA-nanoprobe for optically tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells, Nucleic Acids Research, 2016, DOI: 10.1093/nar/gkw1205.\r
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Lu Chen, Simin Fang, Xianjin Xiao*, Bo Zheng, and Meiping Zhao*, Single-Stranded DNA Assisted Cell Penetrating Peptide?DNA Conjugation Strategy for Intracellular Imaging of Nucleases, Analytical Chemistry, 2016, 88, 11306–11309.\r
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Jiantong Dong, Tongbo Wu, Yu Xiao, Lei Xu, Simin Fang and Meiping Zhao*, A fuel-limited isothermal DNA machine for sensitive detection of cellular deoxyribonucleoside triphosphates, Chemical Communications, 2016, 52, 11923-11926.\r
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陈露，黄山，赵慕华，赵美萍*，郑波，催产素检测方法的研究进展，分析科学学报，2016，32，4，575-581.\r
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Yaoping Liu, Lingqian Zhang, Wengang Wu, Meiping Zhao, and Wei Wang*, Restraining non-specific adsorption of protein using Parylene C-caulked polydimethylsiloxane, Biomicrofluidics, 2016, 10, 024126.\r
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Qi Shen, Changsheng Zhang, Hongbo Liu, Yuting Liu, Junyue Cao, Xiaolin Zhang, Yuan Liang, Meiping Zhao and Luhua Lai*, De Novo Design of Helical Peptides to Inhibit Tumor Necrosis Factor-α by Disrupting Its Trimer Formation, Medical Chemistry Communications, 2016, 7, 725.\r
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Yudan Yin, Lin Niu, Xiaocui Zhu, Meiping Zhao, Zexin Zhang, Stephen Mann, Dehai Liang*, Non-equilibrium behaviour in coacervate-based protocells under electric-field-induced excitation, Nature Communications, 2016, 7, 10658.\r
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Jiantong Dong and Meiping Zhao*, In-vivo fluorescence imaging of adenosine 5'-triphosphate, TrAC Trends in Analytical Chemistry, 2016, 80, 190-203.\r
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Xianjin Xiao, Tongbo Wu, Feidan Gu and Meiping Zhao*, Generation of artificial sequence-specific nucleases via preassembled inert-template, Chemical Science, 2016, 7, 2051-2057.\r
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Simin Fang, Lu Chen and Meiping Zhao*, Unimolecular chemically modified DNA fluorescent probe for onestep quantitative measurement of the activity of human apurinic/ apyrimidinic endonuclease 1 in biological samples, Analytical Chemistry, 2015, 97, 11952-11956.\r
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Yibin Liu, Junqiu Zhai, Jiantong Dong and Meiping Zhao*, Magnetic surface imprinted hydrogel nanoparticles for specific and reversible stabilization of proteins, Molecular Imprinting, 2015, 3, 47-54.\r
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Yibin Liu, Shan Huang, Zhuo Li and Meiping Zhao*, Molecularly imprinted polymers as tools for bioassays and biotransformation, Advances in Biochemical Engineering/Biotechnology, 2015, 150, 207-226.\r
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Tongbo Wu, Xianjin Xiao, Feidan Gu and Meiping Zhao*, Sensitive discrimination of stable mismatched base pairs by abasic site modified fluorescent probe and lambda exonuclease, Chemical Communications, 2015, 51, 17402–17405.\r
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Yibin Liu, Simin Fang, Junqiu Zhai and Meiping Zhao*, Construction of antibody-like nanoparticles for selective protein sequestration in living cells, Nanoscale, 2015, 7, 7162–7167.\r
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Feidan Gu, Xiaoyu Zhou, Xiaocui Zhu, Meiping Zhao*, Jie Hao, Ping Yu and Lanqun Mao*, In-vivo and continuous measurement of bisulfide in the hippocampus of rat’s brain by on-line integrated microdialysis/droplet-based microfluidic system, Analyst, 2015, 140, 3814–3819.\r
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Lin Niu, Xuyan Yang, Xiaocui Zhu, Yudan Yin, Wei Qu, Jihan Zhou, Meiping Zhao* and Dehai Liang*, Dynamic assembly of DNA and polylysine mediated by electric energy.Chemical Communications, 2015, 51, 1506–1509.\r
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Tongbo Wu, Xianjin Xiao, Zhe Zhang and Meiping Zhao*, Enzyme-Mediated Single-Nucleotide Variation Detection at Room Temperature with High Discrimination Factor, Chemical Science, 2015, 6, 1206–1211.\r
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Shuang Zhou, Dan Wang, Chen Zhang, Yunfeng Zhao*, Meiping Zhao* and Yongning Wu, A novel interaction mode between acrylamide and its specific antibody, Journal of Immunoassay and Immunochemistry, 2015, 36, 295–311.