个人简历

EDUCATION\r
1985 B.S. Applied Chemistry, Peking University, Beijing\r
1988 M.S. Analytical Chemistry, Peking Union Medical College, Beijing\r
1995 Ph.D. Organic Chemistry , The Ohio State University, Columbus, Ohio\r
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EXPERIENCE\r
1996-1997, Postdoctoral Research Associate, with Professor Albert Soloway, College of Pharmacy, The Ohio State University, Columbus, Ohio\r
1998-2000, Postdoctoral Research Associate, with Professor Henry Rapoport, Department of Chemistry, University of California, Berkeley, California\r
2000-2010, Professor, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China\r
2010-2015.07, Professor and Director, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China\r
2015.08-Present, Professor, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, China\r
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HONORS AND AWARDS\r
1. Lectureship Awards of Asian Core Program, “Cutting-Edge Organic Chemistry in Asia” (2013, 2012, 2011, 2008, 2006)\r
2. New century talents national candidates (2009)\r
3. “Distinguished Young Investigator” Program, National Natural Science Foundation of China (2006)\r
4. “Post-Venus” Program, Science and Technology Commission of Shanghai Municipal (2005)\r
5. “Venus” Program, Science and Technology Commission of Shanghai Municipal (2002)\r
6.“Hundreds of Talent” Program, Chinese Academy of Sciences (1999)

研究领域

"""""1. Total synthesis of natural products\r
2. Heterocyclic chemistry/medicinal chemistry\r
3. Synthetic methodology development"

近期论文

Xu, B; Xun, W; Su, S; Zhai, H.* Total Syntheses of (–)-Conidiogenone B, (–)-Conidiogenone and (–)-Conidiogenol, Angew. Chem. Int. Ed. 2020, 59, 1−6. DOI: 10.1002/anie.202007247\r
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Zhao, H.; Wang, T.; Qing, Z.; Zhai, H.* Cobalt-catalyzed 2-(1-methylhydrazinyl)pyridine-assisted cyclization of thiophene-2-carbohydrazides with maleimides: efficient synthesis of thiophene-fused pyridones, Chem. Commun., 2020, 56, 5524−5527. DOI: 10.1039/d0cc01582b\r
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Qiu, S.; Zhai, S.; Wang, H.; Chen, X.; Zhai, H.* One-pot synthesis of benzo b fluorenones via a cobalt-catalyzed MHP-directed 3+2 annulation/ring-opening/dehydration sequence. Chem. Commun. 2019, 55, 4206−4209. DOI: 10.1039/c9cc00948e\r
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Zhao, H.; Shao, X.; Qing, Z.; Wang, T.; Chen, X.; Yang, H.; Zhai, H.* Cobalt‐Catalyzed 2‐(1‐Methylhydrazinyl)pyridine‐Assisted Direct C−H/N−H Functionalization of Benzoyl Hydrazide with Isocyanide: Efficient Synthesis of Iminoisoindolinone Derivatives. Adv. Synth. Catal. 2019, 361, 1678−1682. DOI: 10.1002/adsc.20181801459\r
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Zhang, Z.; Xie, S.; Cheng, B.; Zhai, H.*; Li, Y.* Enantioselective Total Synthesis of (+)-Arboridinine, J. Am. Chem. Soc. 2019, 141, 7147−7154. DOI: 10.1021/jacscaal.9b02362\r
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Wang, H.； Qiu, S.； Wang, S.； Zhai, H.* Pd-Catalyzed Umpolung of p-Allylpalladium Intermediates: Assembly of All-Carbon alpha-Vinyl Quaternary Aldehydes through Csp3-Csp3 Coupling, ACS Catal. 2018, 8, 11960−11965. DOI: 10.1021/acscatal.8b03814\r
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Qiu, S.; Zhai, S.; Wang, H. Tao, C.; Zhao,H.; Zhai, H.* Efficient Synthesis of Phthalimides via Cobalt-Catalyzed C(sp(2))-H Carbonylation of Benzoyl Hydrazides with Carbon Monoxide,Adv. Synth. Catal. 2018, 360, 3271−3276. DOI. 10.1002/adsc.201800388\r
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Sa, S.; Liu, M.; Chen, X.; Wang, H.; Zhai, H.* Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 beta-ketoester-functionalized indoles,Chem. Commun. 2018, 54, 8375−8378. DOI: 10.1039/C8CC04499F\r
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Zhai, S.; Qiu,S.; Chen,X.; Tao, C.; Li, Y.; Cheng, B.; Wang, H.; Zhai, H.* Trifunctionalization of Allenes via Cobalt-Catalyzed MHP-Assisted C−H Bond Functionalization and Molecular Oxygen Activation, ACS Catal. 2018, 8, 6645−6649. DOI: 10.1021/acscatal.8b01720\r
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Hua Zhao, Xiaoru Shao, Taimin Wang, Shengxian Zhai, Shuxian Qiu, Cheng Tao, Huifei Wang.; Zhai,H.* A 2-(1-methylhydrazinyl)pyridine-directed C–H functionalization/spirocyclization cascade: facile access to spirosuccinimide derivatives,Chem. Commun. 2018, 54, 4927−4930. DOI: 10.1039/C8CC01774C\r
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Shengxian Zhai, Shuxian Qiu, Xiaoming Chen, Jiang Wu, Hua Zhao,Cheng Tao, Yun Li, Bin Cheng, Huifei Wang and Zhai,H.* 2-(1-Methylhydrazinyl)pyridine as a reductively removable directing group in a cobalt-catalyzed C(sp2)–H bond alkenylation/annulation cascade,Chem. Commun. 2018, 54, 98−101. DOI: 10.1039/C7CC08533H\r
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Xiaoming Chen, Hai-Jun Zhang, Xinkan Yang, Houqiang Lv, Xiaoru Shao, Cheng Tao, Huifei Wang, Bin Cheng, Yun Li, Jingjing Guo, Jing Zhang, Zhai, H.*Divergent Total Syntheses of (-)-Daphnilongeranin B and (-)-Daphenylline, Angew. Chem. Int. Ed. 2018, 57, 947−951. DOI: 10.1002/anie.201709762\r
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Duan, S.; Cheng, B.; Duan, X.; Bao, B.; Li, Y.; Zhai, H.* Synthesis of cis-5,5a,6,10b-Tetrahydroindeno 2,1-b indoles through Palladium-Catalyzed Decarboxylative Coupling of Vinyl Benzoxazinanones with Arynes. Organic Letters. 2018, 20, 1417-1420.. DOI: 10.1021/acs.orglett.8b00192\r
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Li, Y.; Yang, H.; Zhai, H.* The Expanding Utility of Rhodium-Iminocarbenes: Recent Advances in the Synthesis of Natural Products and Related Scaffolds. Chemistry-a European Journal. 2018, 24, 12757-12766. DOI: 10.1002/chem.201800689\r
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Wei, J.; Li, Y.; Tao, C.; Wang, H.; Cheng, B.; Zhai, H.*; Li, Y. Organocatalytic Synthesis of 4-Aryl-1,2,3,4-tetrahydropyridines from Morita-Baylis-Hillman Carbonates through a One-Pot Three-Component Cyclization. J. Org. Chem. 2018, 83, 835-842. DOI: 10.1021/acs.joc.7b02818\r
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Xu, W.; Zhao, J.; Tao, C.; Wang, H.; Li, Y.; Cheng, B.; Zhai, H.* Collective Total Synthesis of (-)-Lundurines A-C. Organic Letters. 2018, 20, 1509-1512. DOI: 10.1021/acs.orglett.8b00210\r
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Tao, Cheng; Zhang, J; Chen, X.-M; Wang, H.-F.; Li, Y; Cheng, B; Zhai, H.* Formal Synthesis of (±)-Aplykurodinone-1 through a Hetero-Pauson–Khand Cycloaddition Approach, Org. Lett. 2017, 19, 1056−1059. DOI: 10.1021/acs.orglett.7b00068\r
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Chen, X.-Z.; Qiu S.-X.; Wang, S.-S; Wang, H.-F.; Zhai, H.* Blue-Light-Promoted Carbon-Carbon Double Bond Isomerization and Its Application in Syntheses of Quinolines, Org. Biomol. Chem. 2017, Accepted Manuscript. DOI: 10.1039/C7OB00558J\r
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Chen, H.-Y.; Shao X.-R.; Wang, H.-F.; Zhai, H.* New reactivity of ethynyl benziodoxolone: modulating iron-catalyzed dehydration of propargyl alcohols, Org. Chem. Front. 2017, Advance Article DOI: 10.1039/C6QO00631K\r
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Zhang, H.-J.;+ Hu, L.;+ Ma, Z.; Li, R.; Zhang, Z.; Tao, C.; Cheng, B.; Li, Y.; Wang, H.; Zhai, H.* Total Synthesis of Diterpenoid (+)-Harringtonolide, Angew. Chem. Int. Ed. 2016, 55, 11638−11641. DOI: 10.1002/anie.201605879