个人简历

1997年获美国北卡罗莱纳大学分子生物学和遗传学博士学位，随后在普林斯顿大学做博士后\r
1999年开始在美国哥伦比亚大学任教。尹玉新教授长期从事肿瘤发生机理的研究，主要关注抑癌基因p53和PTEN在细胞周期调控、细胞凋亡和基因组稳定性中发挥的作用\r
1992年他首次报道p53能够控制人类基因组的稳定性，并证明这一功能是通过其对细胞周期的调控达成的\r
1998年他发现了p53指导细胞对环境压力反应的机理\r
2003年他的研究团队首次揭示出p53下游组织特异性靶基因PAC1，从而在p53和MAP激酶通路之间建立联系。他们还发现RAD9是一个转录因子并且能调控p21以及与细胞周期检验点和胚胎发生相关的其它基因\r
2007年尹玉新课题组发现PTEN是维持染色体功能和结构的柱石，失去PTEN会导致染色体分裂异常和紊乱，从而导致肿瘤发生。他们还首创了条件性PTEN knock-in小鼠模型，用来深入研究PTEN的抗癌机理\r
2008年回国后着重探索PTEN在调控有丝分裂中的新功能\r
2009年申请得到科技部“973”和国家重大科学研究计划项目并被聘为首席科学家。同年他还获批国家自然科学基金重点项目和北京市自然科学基金重大项目\r
2010年他主持成立了北京大学系统生物医学研究所

研究领域

""肿瘤发生机理的研究，主要关注抑癌基因p53和PTEN在细胞周期调控、细胞凋亡和基因组稳定性中发挥的作用""""

近期论文

Chen ZH, Zhu M, Yang J, Liang H, He J, He S, Wang P, Kang X, McNutt MA, Yin Y, et al. PTEN Interacts with Histone H1 and controls chromatin condensation. Cell Reports. 2014;(6):2003-2014.\r
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Sun Z, Huang C, He J, Lamb KL, Kang X, Gu T, Shen WH, Yin Y. PTEN C-Terminal deletion causes genomic instability and tumor development. Cell Reports. 2014;(5):844-854. SCI被引用次数：39.\r
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Chen Z H, Zhu M, Yang J, Liang H, He J, He S, Wang P, Kang X, McNutt M A, Yin Y, et al. PTEN Interacts with Histone H1 and Controls Chromatin Condensation. Cell Reports. 2014.\r
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Liang H, He S, Yang J, Jia X, Wang P, Chen X, Zhang Z, Zou X, McNutt MA, Shen WH, et al. PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism. Cell Metabolism. 2014;(5):836-848. SCI被引用次数：91.\r
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Xu S, Wu Y, Chen Q, Cao J, Hu K, Tang J, Sang Y, Lai F, Wang L, Zhang R, et al. HSSB1 regulates both the stability and the transcriptional activity of p53. Cell Research [Internet]. 2013;(3):423-435. 访问链接 SCI被引用次数：36.\r
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Liang C, Zhang X, Song S, Tian C, Yin Y, Xing G, He F, Zhang L. Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins. Biochemical and Biophysical Research Communications [Internet]. 2013;(4):415-419. 访问链接 SCI被引用次数：4.\r
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Zhou J, Liao W, Yang J, Ma K, Li X, Wang Y, Wang D, Wang L, Zhang Y, Yin Y, et al. FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway. Autophagy [Internet]. 2012;(12):1712-1723. 访问链接 SCI被引用次数：62.\r
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Song S, Xing G, Yuan L, Wang J, Wang S, Yin Y, Tian C, He F, Zhang L. N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents. Cell Research. 2012. SCI被引用次数：9.\r
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Zou X, Liu D, Zhong L, Yang B, Lou Y, Yin Y. Synthesis and characterization of a novel boronic acid-functionalized chitosan polymeric nanosphere for highly specific enrichment of glycopeptides. Carbohydrate Polymers [Internet]. 2012;(2):799-804. 访问链接 SCI被引用次数：14.\r
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Yuan L, Tian C, Wang H, Song S, Li D, Xing G, Yin Y, He F, Zhang L. Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis. EMBO Reports [Internet]. 2012;(4):363-370. 访问链接 SCI被引用次数：14.\r
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Liu L, Yu S, Khan RS, Homma S, Schulze CP, Blaner WS, Yin Y, Goldberg IJ. Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice. Journal of Lipid Research [Internet]. 2012;(8):1482-1492. 访问链接 SCI被引用次数：24.\r
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Song S, Xing G, Yuan L, Wang J, Wang S, Yin Y, Tian C, He F, Zhang L. N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents. Cell Research [Internet]. 2012;(8):1285-1303. 访问链接 SCI被引用次数：9.\r
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Nie J, Liu L, Wu M, Xing G, He S, Yin Y, Tian C, He F, Zhang L. Erratum: HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation (FEBS Letters (2010) 584 (3005-3012)). FEBS Letters. 2011;(1):266-. SCI被引用次数：0.\r
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Xie P, Li L, Xing G, Tian C, Yin Y, He F, Zhang L. ATM-mediated NuSAP phosphorylation induces mitotic arrest. Biochemical and Biophysical Research Communications [Internet]. 2011;(1):413-418. 访问链接 SCI被引用次数：10.\r
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Gu T, Zhang Z, Wang J, Guo J, Shen WH, Yin Y. CREB is a novel nuclear target of PTEN phosphatase. Cancer Research [Internet]. 2011;(8):2821-2825. 访问链接 SCI被引用次数：64.\r
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Guo X, Shen S, Song S, He S, Cui Y, Xing G, Wang J, Yin Y, Fan L, He F, et al. The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum. Journal of Biological Chemistry [Internet]. 2011;(20):18037-18047. 访问链接 SCI被引用次数：34.\r
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Zou X, Liu D, Zhong L, Yang B, Lou Y, Hu B, Yin Y. Highly specific capture and direct MALDI-MS analysis of phosphorylated peptides using novel multifunctional chitosan-GMA-IDA-Fe (III) nanosphere. Analytical and Bioanalytical Chemistry [Internet]. 2011;(4):1251-1261. 访问链接 SCI被引用次数：24.\r
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Zou X, Zhong L, Liu D, Yang B, Lou Y, Peng J, Rainer M, Feuerstein I, Muhammad N-U-H, Huck CW, et al. Novel multifunctional chitosan-GMA-IDA-Cu(II) nanospheres for high dynamic range characterization of the human plasma proteome. Analytical and Bioanalytical Chemistry [Internet]. 2011;(3):747-756. 访问链接 SCI被引用次数：7.\r
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Xie P, Tang Y, Shen S, Wang Y, Xing G, Yin Y, He F, Zhang L. Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells. Biochemical and Biophysical Research Communications [Internet]. 2011;(1):254-259. 访问链接 SCI被引用次数：26.