个人简历

2008-present Professor, College of Chemistry, Peking University\r
2004-2008 Associate Professor, College of Chemistry, Peking University\r
2001-2004 Postdoc. University of California, Los Angeles\r
1997-2001 Ph.D, The Hong Kong University of Science and Technology (computational organic chemistry)\r
1994-1997 MS, Peking University (synthetic organic chemistry)\r
1987-1991 BS, Department of Chemistry, Wuhan University\r
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Honors, Awards and Recognitions\r
1. Chang-Jiang Professorship, Ministry of Education, China, 2015\r
2. Nankai University Lectureship on Organic Chemistry, 2014\r
3. Advisor of the Best 100 Ph.D Theses in China, 2012, Ministry of Education, China\r
4. The Asian Core Program Lectureship Award (Singapore), the Asian Cutting-Edge Organic Chemistry programs, 2012\r
5. “Chinese Chemical Society-Sci Finder Award for Creative Work in Synthetic Organic Chemistry”, 2011\r
6. “Chinese Chemical Society-Physical Organic Chemistry Award”, 2011\r
7. “Chinese Chemical Society-BASF Award”, 2011\r
8. “Distinguished Lectureship Award”, the Asian Symposium of Annual Meeting of Chemical Society of Japan, 2010\r
9. The Asian Core Program Lectureship Award (Japan), the Asian Cutting-Edge Organic Chemistry programs, 2008\r
10. The National Science Fund for Distinguished Young Scholars of China, 2008\r
11. The Young Chemist Award, the Chinese Chemical Society & the Royal Society of Chemistry, 2008\r
12. Thieme Synlett/Synthesis Journal Award, 2008\r
13. Nominated for the Chancellor's Award for Postdoctoral Research, University of California, Los Angeles, 2004\r
14. Research Excellence Award, Department of Chemistry & Biochemistry, University of California, Los Angeles, 2004.

研究领域

"""""1. Developing theories and understanding reaction mechanisms;\r
2. Developing new reactions and catalysts;\r
3. Synthesizing natural products and pharmaceutical molecules;\r
4. Developing new drugs and studying chemical biology."

近期论文

Computational Study of Mechanisms and Tether Length Effects of Rh-Catalyzed [3+2] and [3+2+1] Reactions of Ene/Yne- Vinylcyclopropanes Guan-Yu Zhang, Mu Lin, and Zhi-Xiang Yu*Chem Asian J. 2023, e202300032\r
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Antrodiellin B/hypnophilin/coriolin and strained 5/5/5 and 5/6/4 skeletons via [5+2+1]/epoxidation/transannular radical cyclization Lu-Ning Wang, Zhiqiang Huang, Zhi-Xiang Yu*Cell Reports Physical Science 2023, 4, 101302.\r
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Synthesis of Polycyclic n/5/8 and n/5/5/5 Skeletons Using Rhodium-Catalyzed [5 + 2 + 1] Cycloaddition of Exocyclic-ene-vinylcyclopropanes and Carbon Monoxide Lu-Ning Wang#, Zhiqiang Huang#, and Zhi-Xiang Yu*Org. Lett. 2023, 25, 1732–1736.\r
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Strain-Release-Controlled [4 + 2 + 1] Reaction of Cyclopropyl-Capped Diene-ynes/Diene-enes and Carbon Monoxide Catalyzed by Rhodium Chen-Long Li#, Yusheng Yang#, Yi Zhou#, Zhao-Chen Duan, and Zhi-Xiang Yu*J. Am. Chem. Soc., 2023, 145, 5496–5505.\r
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Unprecedented endo-oxidative cyclometallation and [4 + 3] cycloaddition of diene-vinylcyclopropanes Jun Yang#, Pan Zhang#, Zeyuan Shen, Yi Zhou, Zhi-Xiang Yu*Chem. 2023, 9, 10.1016/j.chempr.2023.01.020.\r
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Metalla-Claisen Rearrangement in Gold-Catalyzed [4+2] Reaction: A New Elementary Reaction Suggested for Future Reaction Design Jing Liu+, Yusheng Yang+, Weiming Shi+, and Zhi-Xiang Yu*Angew. Chem. Int. Ed. 2023, e202217654.\r
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Formal Hydrotrimethylsilylation of Styrenes with Anti-Markovnikov Selectivity Using Hexamethyldisilane Xin Wang, Zhi-Xiang Yu*, and Wen-Bo Liu*Org. Lett. 2022, 24, 8735–8740\r
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DFT Study of Mechanism and Stereochemistry of Nickel-Catalyzed trans-Arylative Desymmetrizing Cyclization of Alkyne-Tethered Malononitriles Yu-Qing Zheng, Chen-Long Li, Wen-Bo Liu*, and Zhi-Xiang Yu*J. Org. Chem. 2022, 87, 16079–16083\r
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Dual Activation Strategy to Achieve C–C Cleavage of Cyclobutanes: Development and Mechanism of Rh and Zn Cocatalyzed [4 + 2] Cycloaddition of Yne-Vinylcyclobutanones Guan-Yu Zhang†, Pan Zhang†, Bing-Wen Li†, Kang Liu, Jun Li, and Zhi-Xiang Yu*J. Am. Chem. Soc. 2022, 144, 21457–21469\r
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Atroposelective Synthesis of N-Arylindoles via Enantioselective N–H Bond Insertion Chao Niu#, Yi Zhou#, Qiang Chen, Yan Zhu, Shengbiao Tang, Zhi-Xiang Yu*, and Jiangtao Sun*Org. Lett. 2022, 24, 7428–7433\r
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Syntheses of (+)-Antrodiellin B, (−)-Hypnophilin and (−)-Coriolin and Strained 5/5/5 and 5/6/4 Skeletons via [5+2+1]/Epoxidation/Transannular Radical Cyclization Lu-Ning Wang, Zhiqiang Huang and Zhi-Xiang Yu*ChemRxiv 2022. 10.26434/chemrxiv-2022-lxlfz.\r
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Selective Enyne Ring-Closing Metathesis with Main Group Metal Catalysts Yi Wang, Lian-Gang Zhuo, Chi Zhang, and Zhi-Xiang Yu*ChemRxiv 2022. 10.26434/chemrxiv-2022-7bm1b\r
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Strain-Release Controlled [4+2+1] Reaction of Cyclopropyl-Capped Diene-Ynes/Diene-enes and CO Catalyzed by RhodiumChen-long Li, Yusheng Yang, Zhao-Chen Duan, Yi Zhou, Zhi-Xiang, Yu*ChemRxiv 2022, 10.26434/chemrxiv-2022-9g62z-v2\r
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Total Synthesis of Clovan-2,9-dione via [3 + 2 + 1] Cycloaddition and Hydroformylation/Aldol Reaction Yi Zhou, Jun-Long Qin, Wenbo Xu, and Zhi-Xiang Yu* Org. Lett. 2022, 24, 5902–5906.\r
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Why [4 + 2 + 1] but Not [2 + 2 + 1]? Why Allenes? A Mechanistic Study of the Rhodium-Catalyzed [4 + 2 + 1] Cycloaddition of In Situ Generated Ene–Ene–Allenes and Carbon Monoxide Yusheng Yang, Zi-You Tian, Chen-Long Li, and Zhi-Xiang Yu*. J. Org. Chem. 2022, 87, 10576–10591.\r
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Stereoselective hydrogen atom transfer to acyclic radicals: a switch enabling diastereodivergent borylative radical cascades Tian Ye, Feng-Lian Zhang, Hui-Min Xia, Xi Zhou, Zhi-Xiang Yu*, Yi-Feng Wang* Nat. Commun. 2022, 13, 426.\r
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Catalytic Enantioselective Construction of 6-4 Ring-Junction All-Carbon Stereocenters and Mechanistic Insights Jia-Yin Wang, Chen-Long Li, Ting Xu, Meng-Fan Li, Wen-Juan Hao, Shu-Jiang Tu, Jianyi Wang,* Guigen Li, Zhi-Xiang Yu,* and Bo Jiang* Chin. J. Chem. 2022, 40, 1767.\r
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Six-Step Total Synthesis of Isohirsut-4-ene through [5+2+1] Cycloaddition and Transannular Epoxide–Alkene Cyclization Jing Liu§, Yi Zhou§, and Zhi-Xiang Yu*. Org. Lett. 2022, 24, 1444-1447.\r
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Mechanism and Stereochemistry of Rhodium-Catalyzed [5 + 2 + 1] Cycloaddition of Ene−Vinylcyclopropanes and Carbon Monoxide Revealed by Visual Kinetic Analysis and Quantum Chemical Calculations Yi Wang, Wei Liao, Yuanyuan Wang, Lei Jiao, and Zhi-Xiang Yu* J. Am. Chem. Soc. 2022, 144, 2624.\r
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Palladium-Catalyzed [3 + 2] Annulation of Alkynes with Concomitant Aromatic Ring Expansion: A Concise Approach to (Pseudo)azulenes\r
Fulin Zhou, Weiming Shi, Xingrong Liao, Yudong Yang*, Zhi-Xiang Yu*, and Jingsong You* ACS Catal. 2022, 12,676–686.\r
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Ynamide Protonation-Initiated Cis-Selective Polyene Cyclization and Reaction Mechanism J.asheng Yao†, Chen-Long Li†, Xing Fan, Zhou Wang, Zhi-Xiang Yu* and Junfeng Zhao* CCS Chem. 2022, 4, 2991–3001.\r
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A Formal [3+3+1] Reaction of Enyne-Methylenecyclopropanes through Au(I)-Catalyzed Enyne Cycloisomerization and Rh(I)-Catalyzed [6+1] Reaction of Vinylspiropentanes and CO\r
Dr. Chen-Long Li, Yusheng Yang, Yi Zhou, Prof. Dr. Zhi-Xiang Yu* Asian J. Org. Chem. 2022, 11, e202100571.\r
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Synthesizing Molecules with Linear Tricyclic 5/5/5 and 6/5/5 Skeletons via [5 + 2 + 1]/Ene Strategy J.ng Liu, Yi Zhou, Jiaqi Zhu, and Zhi-Xiang Yu*. Org. Lett. 2021, 23, 7566-7570.\r
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(Z)-γ-Alkylidenebutenolide Synthesis through Au(I)-Catalyzed 1,3-Acyloxy Migration and the Carbonyl–Ene Reaction Pathan Mosim Amin, Qi Cui, Shaozhong Wang*, Zhi-Xiang Yu*. Org. Lett. 2021, 23, 5669–5673.\r
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Ni-catalyzed hydroaminoalkylation of alkynes with amines Wei-Wei Yao, Ran Li, Hao Chen, Ming-Kai Chen, Yu-Xin Luan, Yi Wang , Zhi-Xiang Yu* and Mengchun Ye*Nat. Commun. 2021, 12, 3800.\r
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Co-Catalyzed Asymmetric Intramolecular [3+2] Cycloaddition of Yne-Alkylidenecyclopropanes and its Reaction Mechanism Xiong Xiao and Zhi-Xiang Yu*. Chem. Eur. J. 2021, 27, 7176–7182.\r
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Iodoarene-Catalyzed Oxyamination of Unactivated Alkenes to Synthesize 5‑Imino-2-Tetrahydrofuranyl Methanamine Derivatives Xiao-Jun Deng, Hui-Xia Liu, Lu-Wen Zhang, Guan-Yu Zhang, Zhi-Xiang Yu,* and Wei He* J. Org. Chem. 2021, 86, 235−253.\r
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Rhodium(I)-Catalyzed Three-Component [4+2+1] Cycloaddition of Two Vinylallenes and CO Qi Cui, Zi-You Tian, and Zhi-Xiang Yu* Chem. Eur. J. 2021, 27, 5638 – 5641\r
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Density Functional Theory Study of Mechanisms of [8 + 2] Cycloadditions of Dienylfurans/Dienylisobenzofurans with DMAD Qi Cui, Yuanyuan Chen, James W. Herndon, and Zhi-Xiang Yu* J. Org. Chem. 2021, 86, 1419−1429.\r
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A Combined Computational and Experimental Study of Rh- Catalyzed C−H Silylation with Silacyclobutanes: Insights Leading to a More Efficient Catalyst System Linxing Zhang,# Kun An,# Yi Wang,# Yun-Dong Wu, Xinhao Zhang,* Zhi-Xiang Yu,* and Wei He* J. Am. Chem. Soc. 2021, 143, 3571.\r
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Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles: an Update from 2010 to 2020 Wang Lu-Ning, Yu Zhi-Xiang*Chinese Journal of Organic Chemistry, 2020, 40, 3536-3558.\r
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Mechanism and Regioselectivity of Intramolecular [2+2] Cycloaddition of Ene–Ketenes: A DFT Study Xing Fan,Pan Zhang, Yi Wang, and Zhi-Xiang Yu* Eur. J. Org. Chem. 2020, 37, 5985.\r
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Synergy of activating substrate and introducing C–H···O interaction to achieve Rh2(II)-catalyzed asymmetric cycloisomerization of 1,n-enynes Rui Wu, Kai Chen, Jun Ma, Zhi-Xiang Yu*, and Shifa Zhu*Science China Chemistry 2020, 63, 1230–1239.\r
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Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes Kuiyong Dong, Xing Fan, Chao Pei, Yang Zheng, Sailan Chang, Ju Cai, Lihua Qiu, Zhi-Xiang Yu* and Xin-fang Xu*Nature Communications2020, 11, 2363\r
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Remote γ-C(sp3)–H Alkylation of Aliphatic Carboxamides via an Unexpected Regiodetermining Pd Migration Process: Reaction Development and Mechanistic Study Ya Li, Pan Zhang, Yue-Jin Liu, Zhi-Xiang Yu*, and Bing-Feng Shi* ACS Catal. 2020, 10, 8212–8222\r
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Lewis Base-Catalyzed Amino-Acylation of Arylallenes via C–N Bond Cleavage: Reaction Development and Mechanistic Studies Zheng-Bing Zhang, Yusheng Yang, Zhi-Xiang Yu*, and Ji-Bao Xia* ACS Catal. 2020, 10, 5419–5429\r
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Mechanistic Study on Gold-Catalyzed Cycloisomerization of Dienediynes Involving Aliphatic C−H Functionalization and Inspiration for Developing a New Strategy to Access Polycarbocycles Yi Wang, Pei-Jun Cai, and Zhi-Xiang Yu* J. Am. Chem. Soc. 2020, 142, 2777−2786\r
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Symmetric C···H···C Hydrogen Bonds Predicted by Quantum Chemical Calculations Yi Wang and Zhi-Xiang Yu* J. Org. Chem. 2020, 85, 397−402\r
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NHC-Boryl Radical Catalysis for Cycloisomerization With C–C Triple Bond Reorganization Ai-Qing Xu, Feng-Lian Zhang, Tian Ye, Zhi-Xiang Yu*, and Yi-Feng Wang* CCS Chem. 2019, 1, 504–512\r
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Rh-Catalyzed Cycloisomerization of 1,7-Ene-Dienes to Synthesize trans-Divinylpiperidines: A Formal Intramolecular Addition Reaction of Allylic C-H Bond into Dienes Qi Cui, Wei Liao, Zi-You Tian, Qian Li, and Zhi-Xiang Yu Org. Lett. 2019, 21, 7692-7696\r
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A newly designed heterodiene and its application to construct six-membered heterocycles containing an N–O bond Wenzhi Ji, Chen-Long Li, Hui Chen, Zhi-Xiang Yu* and Xuebin Liao* Chem. Commun. 2019, 55, 12012\r
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Synthesis of Quaternary Carbon-Centered Benzoindolizidinones via Novel Photoredox-Catalyzed Alkene Aminoarylation: Facile Access to Tylophorine and Analogues Chao Zhang, Yi Wang, Yugang Song, Hongying Gao, Yonghui Sun, Xiuyun Sun, Yiqing Yang, Ming He, Zimo Yang, Lingpeng Zhan, Zhi-Xiang Yu*, and Yu Rao*CCS Chem. 2019, 1, 352−364\r
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Divergent Synthesis of Oxa-Cyclic Nitrones through Gold(I)- Catalyzed 1,3-Azaprotio Transfer of Propargylic a-Ketocarboxylate Oximes: Experimental and DFT Studies Chunhong Wang, Qi Cui, Zhixin Zhang, Zhu-Jun Yao, Shaozhong Wang*, and Zhi-Xiang Yu* Chem. Eur. J. 2019, 25, 9821 – 9826\r
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Asymmetric Synthesis of Azepine-Fused Cyclobutanes from Yne- Methylenecyclopropanes Involving Cyclopropanation/C−C Cleavage/Wagner−Meerwein Rearrangement and Reaction Mechanism Chen-Long Li and Zhi-Xiang Yu* J. Org. Chem. 2019, 84, 9913−9928\r
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Type-II Pauson-Khand reaction of 1,8-enyne in the attempt of building 7/5 ring of (-)-caribenol A and DFT understanding Yang Wang, Kang Liu, Zhi-Xiang Yu*, Yanxing Jia*Tetrahedron Lett. 2019, 60, 151001\r
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Understanding Regioselectivities of Corey–Chaykovsky Reactions of Dimethylsulfoxonium Methylide (DMSOM) and Dimethylsulfonium Methylide (DMSM) toward Enones: A DFT Study. Yu Xiang, Xing Fan, Pei-Jun Cai, Zhi-Xiang Yu* Eur. J. Org. Chem. 2019, 582-590\r
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Copper-catalyzed Intramolecular Annulation of Conjugated Enynones to Substituted 1H-Indenes and Mechanistic Studies.Chao Pei, Guang-Wei Rong, Zhi-Xiang Yu*, Xin-Fang Xu* J. Org. Chem. 2018, 83, 13243-13255\r
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Rhodium-Catalyzed [4+2+1] Cycloaddition of In Situ Generated Ene/Yne-Ene-Allenes and CO Zi-You Tian, Qi Cui, Cheng-Hang Liu, Zhi-Xiang Yu* Angew. Chem. Int. Ed. 2018, 57, 15544-15548\r
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Two-Fold C−H/C−H Cross-Coupling Using RhCl3·3H2O as the Catalyst: Direct Fusion of N‑(Hetero)arylimidazolium Salts and (Hetero)arenes Zhijie She, Yi Wang, Deping Wang, Yinsong Zhao, Tianbao Wang, Xuesong Zheng, Zhi-Xiang Yu*, Ge Gao* and Jingsong You* J. Am. Chem. Soc. 2018, 140, 12566-12573\r
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Rhodium(II)-catalysed generation of cycloprop-1-en-1-yl ketones and their rearrangement to 5-aryl-2-siloxyfurans Kostiantyn O. Marichev, Yi Wang, Alejandra M. Carranco, Estevan C. Garcia, Zhi-Xiang Yu* and Michael P. Doyle* Chem. Commun. 2018, 54, 9513-9516\r
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RhI-Catalyzed Intramolecular [3+2] Cycloaddition of 1-Allene-vinylcyclopropanes Cheng-Hang Liu, Feng Li, Yuan Yuan, Meng Dou, and Zhi-Xiang Yu* Asian J. Org. Chem. 2018, 7, 1609-1613\r
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TfOH and HBF4 Mediated Formal Cycloisomerizations and [4+3] Cycloadditions of Allene-Alkynylbenzenes Yu Xiang, Zining Li, Lu-Ning Wang, and Zhi-Xiang Yu* J. Org. Chem. 2018, 83, 7633-7647\r
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Formal Insertion of Imines (or Nitrogen Heteroarenes) and Arynes into the C−Cl Bond of Carbon Tetrachloride Sheng-Jun Li, Yi Wang, Jing-Kun Xu, Dong Xie, Shi-Kai Tian*, and Zhi-Xiang Yu* Org. Lett. 2018, 20, 4545-4548\r
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Intra- versus Intermolecular Carbon-to-Carbon Proton Transfers in the Reactions of Arynes with Nitrogen Nucleophiles: A DFT Study.Yi Wang and Zhi-Xiang Yu* J. Org. Chem. 2018, 83, 5384-5391\r
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Rh(I)-Catalyzed Intramolecular [3+2] Cycloaddition of trans-2-Allene-Vinylcyclopropanes.Cheng-Hang Liu and Zhi-Xiang Yu*Synlett. 2018, 29, 764-768\r
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Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes by Ring Closing Metathesis Minggui Lin, Pei-Jun Cai, Zhixiong Zeng, Na Lin, Yang Shen, Bin Tang, Fan Li, Chen Chen, Zhi-Xiang Yu*, Yandong Zhang* Chem. Eur. J. 2018, 24, 2334-2338\r
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