个人简历
受教育经历 2000.9 –2003.12，北京大学药学院化学生物学系，博士，王夔教授，杨晓达教授 1997.9 –2000.7，华中科技大学化学系，硕士，徐辉碧教授，刘长林教授 1992.9 –1996.7，四川轻化工学院化学工程系，学士，王曙教授 研究工作经历 2018.1至今，北京大学药学院分子与细胞药理学系，副教授，博士生导师 2008.12 - 2017.12，北京大学药学院化学生物学系，副教授，硕士生导师 2004.12 –2008.12，美国Rutgers, The State University of New Jersey，博士后 2003.12 -2004.12，成都新康药业有限公司，总经理助理 1996.7 –1997.7，四川广康化纤股份有限公司，助理工程师
研究领域
余四旺课题组主要围绕机体和细胞的应激信号转导机制，运用多种化学和分子、细胞、动物模型等手段，结合临床样本和数据，研究癌症及相关代谢性疾病发生发展、预防和治疗中的细胞与分子机制以及相应的生物标志物和干预靶标；进而在个体化预测疾病发生发展转归的基础上，发现和利用天然或合成的化学或生物物质对关键病理环节进行针对性干预或预防性治疗，并探索这些物质的作用机制。
近期论文
Cao M, Wang H, Guo L, Yang S, Liu C, Khor TO, Yu S*, Kong AN. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017;19(6):1703-1714 Cheng W, Liu Z, Yu Y, van Ofwegen L, Proksch P, Yu S*, Lin W*, An unusual spinaceamine-bearing pregnane from a soft coral Scleronephthya sp. inhibits the migration of tumor cells, Bioorg Med Chem Lett, 2017;27(12):2736-2741 Ji L, Yang S, Li S, Liu S, Tang S, Liu Z, Meng X*, Yu S*, A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes, Oncotarget, 2017;8(23):37394-37408 Ji S, Tang S, Li K, Li Z, Liang W, Qiao X, Wang Q, Yu S*, Ye M*, Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy, Toxicol Appl Pharmacol, 2017;326:25-33 Li K, Ji S, Song W, Kuang Y, Lin Y, Tang S, Cui Z, Qiao X, Yu S, Ye M*, Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra, J Nat Prod, 2017;80(2):334-346 Que L, He L, Yu C, Yin W, Ma L, Cao B*, Yu S*, Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression, Toxicol Lett, 2016; 262:17-26 Zhao, Y., Liu, D., Proksch, P., Yu, S.*, Lin, W.*, Isocoumarin Derivatives from the Sponge-Associated Fungus Peyronellaea glomerata with Antioxidant Activities, Chem Biodivers, 2016 Jul 23. doi: 10.1002/cbdv.201600012 Yang, J., Yang, S., Zhou, S., Lu, D., Ji, L., Li, Z., Yu, S.*, Meng, X.*, Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents, Eur J Med Chem. 2016 Oct 21;122:488-496 Wu ZH, Wang YR, Liu D, Proksch P, Yu SW*, Lin WH*. Antioxidative phenolic compounds from a marine-derived fungus Aspergillus versicolor. Tetrahedron. 2016; 72(1):50-57. Ji S, Li Z, Song W, Wang Y, Liang W, Li K, Tang S, Wang Q, Qiao X, Zhou D, Yu S*, Ye M*. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. J Nat Prod. 2016;79(2):281-292. Yu S*, Yang CS, Li J, You W, Chen JG, Cao Y, Dong Z, Qiao YL, Cancer Prevention Research in China, Cancer Prev Res (Phila), 2015, 8(8):662-74 (Cover story) Guo Y, Yu S*, Zhang C, Tony Kong AN, Epigenetic regulation of Keap1-Nrf2 signaling, Free Radic Biol Med, doi:10.1016/j.freeradbiomed.2015.06.013 Ji S, Li R, Wang Q, Miao WJ, Li ZW, Si LL, Qiao X, Yu SW, Zhou DM, Ye M, Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis. J Ethnopharmacol. 2015 Nov 11. pii: S0378-8741(15)30221-X. Zhang C, Zhong B, Yang S, Pan L, Yu S, Li Z, Li S, Su B, Meng X, Synthesis and biological evaluation of thiabendazole derivatives as anti-angiogenesis and vascular disrupting agents, Bioorg Med Chem, 2015, 23(13):3774-80 Yang SM, Ji LY, Que LL, Wang K, Yu SW*, Metformin activates Nrf2 signaling and induces the expression of antioxidant genes in skeletal muscle and C2C12 myoblasts, J Chin Pharma Sci, 2014, 23(12):837-43 Jian Bai, Dong Liu, Siwang Yu, Peter Proksch, Wenhan Lin, Amicoumacins from the marine-derived bacterium Bacillus sp. with the inhibition of NO production, Tetrahedron Letters, 2014, 55(45):6286–6291 Yang J, Zhou S, Ji L, Zhang C, Yu S, Li Z, Meng X, Synthesis and structure-activity relationship of 4-azaheterocycle benzenesulfonamide derivatives as new microtubule-targeting agents, Bioorg Med Chem Lett, 2014, 24(21):5055-5058 Lou Q, Ji L, Zhong W, Li S, Yu S*, Li Z, Meng X*, Synthesis and cytotoxicity evaluation of naphthalimide derived N-mustards, Molecules, 2014, 19(7):8803-19
