个人简历

教育经历\r
1984 - 1991 , 博士 , 哈佛医学院\r
1978 - 1983 , 学士 , 北京医学院\r
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工作经历\r
2013 - 至今 , 院长 , 北京大学生命科学学院\r
2011 - 2013 , 主任 , 美国加州大学洛杉矶分校分子医学研究所\r
2009 - 至今 , David Geffen Chair in Medical Research , 美国加州大学洛杉矶分校\r
2008 - 2011 , 副主任 正式成员 , 美国加州大学洛杉矶分校分子医学研究所\r
1997 - 2004 , 助理研究员 , 霍华德-休斯医学研究所\r
1996 - 2013 , 助理教授、副教授、教授 , 美国加州大学洛杉矶分校分子与医学药理学系\r
1991 - 1996 , 博士后 , 麻省理工学院Whitehead研究所

研究领域

""吴虹教授长期致力于肿瘤分子遗传学的研究，重点探讨抑癌基因在肿瘤发生、发展及耐药中的分子机制。她所领导的团队在抑癌基因信号传递、肿瘤干细胞及基因工程动物模型等研究方面做了大量的杰出工作，其研究成果对于发现肿瘤发生的分子机制以及肿瘤治疗的新途径有重大的理论及实际意义。\r
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主要的研究方向包括\r
1. PTEN调控干细胞和肿瘤干细胞的分子遗传机制\r
2. 前列腺癌单细胞图谱及癌细胞与肿瘤微环境的互作网络绘制\r
3. 天然免疫及细胞坏死在前列腺癌进展中的作用机制\r
4. 肿瘤发生过程中的代谢重编程""""

近期论文

Yang L#., Chen F#., Zhu H#., Chen Y., Dong B., Shi M., Wang W., Jiang Q., Zhang L., Huang X., Zhang M., Wu H. （2021） 3D Genome Alterations Associated with Dysregulated HOXA13 Expression in High-Risk T-Lineage Acute Lymphoblastic Leukemia; Nature Communication (accepted)\r
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Cheng. J., Huang. Y., Zhang. X, Yu. Y., Wu. S., Jiao J., Tran. L., Zhang, W., Liu. R., Zhang, L., Wang. M., Wang, M., Yan, W., Wu, Y., Chi, F., Jiang. P., Zhang. X., and Wu, H.(2020) TRIM21 and PHLDA3 Negatively Regulate the Crosstalk between the PI3K/AKT Pathway and PPP Metabolism. Nat Commun. 20;11(1):1880. PMID: 32312982\r
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Wu, Y., Zhu, H., and Wu, H. (2019). PTEN in Regulating Hematopoiesis and Leukemogenesis. Cold Spring Harb Perspect Med. PMID:31712222.\r
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Zhu, H., Zhang, L., Wu, Y., Dong, B., Guo, W., Wang, M., Yang, L., Fan, X., Tang, Y., Liu, N., Lei X., and Wu H. (2018). T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1. Elife 7. PMID: 30412053\r
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Zou, Y., Qi, Z., Guo, W., Zhang, L., Ruscetti, M., Shenoy, T., Liu, N., and Wu, H. (2018). Cotargeting the Cell-Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kalpha/beta/delta Inhibitor BAY1082439. Mol Cancer Ther 17, 2091-2099. PMID: 30045927\r
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Shenoy, T.R., Boysen, G., Wang, M.Y., Xu, Q.Z., Guo, W.L., Koh, F.M., Wang, C., Zhang, L.Z., Wang, Y., Gil, V., Aziz, S., Christova, R., Rodrigues, D.N., Crespo, M., Rescigno, P., Tunariu, N., Riisnaes, R., Zafeiriou, Z., Flohr, P., Yuan, W., Knight, E., Swain, A., Ramalho-Santos, M., Xu, D.Y., de Bono, J. and Wu, H. (2017) CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair. Ann Oncol. Jul 1;28(7):1495-1507.PMID: 28383660\r
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Schubbert S., Jiao, J., Ruscetti, M., Nakashima, J., Wu, S., Lei, H., Xu, Q., Yi, W., Zhu, H., Wu, H. (2016) Methods for PTEN in Stem Cells and Cancer Stem Cells Methods Mol. Biol. 1288:233-85. PMID:27033080\r
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Ruscetti, M., Dadashian, E.L., Guo, W., Quach, B., Mulholland D.J., Park J.W., Tran, L.M., Kobayashi, N., Bianchi-Frias, D., Nelson, P.S., Xing, Y. and Wu, H. (2016) HDAC Inhibition Impedes Epithelial-Mesenchymal Plasticity and Suppresses Metastatic, Castration-Resistant Prostate Cancer. Oncogene. 2016.7.21, 35(29): 3781~3795 PMID:26640144\r
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Ruscetti, M., Quach, B., Dadashian, E.L., Mulholland, D.J. and Wu, H. (2015) Tracking and functional characterization of EMT and mesenchymal-like tumor cells in prostate cancer metastasis. Cancer Res. 75:2749-59. PMCID:PMC4490048.\r
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Schubbert S, Cardenas A, Chen H, Garcia C, Guo W, Bradner JE, Wu H.　　Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T cell acute lymphoblastic leukemia. (2014) Cancer Res74：7048-59.PMCID:PMC4258248\r
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Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. (2014) A Uniform Nomenclature and Amino Acid Numbering for Human PTEN. Science Signal. 7: pe15PMCID:PMC4367864\r
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Garcia, A.J., Ruscetti, M., Arenzana, T.L., Tran, L.M., Frias D.B., Sybert, E., Priceman, S.J., Wu, L., Nelson, P., Smale, S and Wu, H. (2014) Pten null prostate epithelium promotes localized MDSC expansion and immune suppression during tumor initiation and progression. Mol Cell Biol. 34:2017-2028. PMCID:PMC4019050\r
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Mulholland, D., and Wu, H. (2013) A Book Chapter in “Stem Cells and Prostate Cancer”; Chapter 5 – Genetic and Signaling Pathway Regulations Springer Science-Business Media 77-89.\r
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Smith, K.B., Tran, L.M., Tam, B.,Shurell, E.M., Li, Y., Braas, D., Tap, W.D., Christofk, H.R., Dry, S.M., Eiber, F.C., and Wu, H. (2013) Novel dedifferentiated liposarcoma xenograft models reveal PTEN down regulation as a malignant Signature and Response to PI3K Pathway Inhibition. American Journal of Pathology 182(4):1400-11. PMCID: PMC3620414.\r
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Schlacher, K., Wu, H., and Jasin, M. (2012) A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2. Cancer Cell 22(1):106-16. PMID: 22789542\r
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14. Hubner, A., Mulholland, D., Standen, C., Karasarides, M., Cavanagh-Kyros, J., Barrett, T., Chi, H., Greiner, D., Tournier, C.,　　Flavell, R., Sawyers, C., Wu H., and Davis, R. (2012) JNK and PTEN co-operatively control the development of invasive adenocarcinoma of the prostate. Proc. Natl. Acad. Sci. USA109(30):12046-51. PMCID: PMC3409732\r
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Mulholland, D., Kobayashi, N., Ruscetti, M., Zhi, A., Tran, L.M., Huang, J., Gleave, M and Wu, H (2012) Pten loss and RAS/MAPK activation coorperate to promote EMT and prostate cancer metastasis initiated from stem/progenitor cells. Cancer Res.72 (7):1878-89. PMCID: PMC3319847\r
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Tran, L.M., Chang, C., Plaisier, S., Dang, J., Mischel, P.S., Liao, J., Graeber, T.G. and Wu, H. (2012) Determining PTEN functional status by network component deducted transcription factor activities. PLoS One 7(2):e31053. PMCID: PMC 3275574\r
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Donahue, T.R., Tran, M.L., Hill, R., Li, Y, Kovochich, A., Calvopina, J., Patel, S.G., Farrell, J.J., Li, X., Dawson, D. and Wu, H. (2012) Integrative survival-based molecular profiling of Human Pancreatic Cancer. Clinic Cancer Res.18(5): 1352-63. PMID: 22261810\r
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Valamehr, B., Tsutsui, H., Ho, C.M., and Wu, H (2011) Developing defined culture system for human pluripotent stem cells. Regen. Med. 6:623-634. PMID: 21916597