个人简历

教育经历: 1999 - 2004 , 博士后 , 遗传学 , Stanford Unversity 1995 - 1999 , 理学博士 , 遗传学 , Michigan State University 1987 - 1991 , 理学学士 , 生物化学 , 北京大学 工作经历: 2016 - 现在 研究员, 北京未来基因诊断高精尖创新中心（ICG） 2015 - 现在 研究员, 北大-清华生命科学联合中心 （CLS） 2014 - 现在 研究员, 北京大学生物医学集成创新研究所（BIOPIC） 2007 - 现在 研究员, 北京大学生命科学学院，生化与分子生物学 2005 - 2007 Research Associate, 美国斯坦福大学医学院遗传学系 1999 - 2004 博士后, 美国斯坦福大学医学院遗传学系

研究领域

研究领域： 真核基因组编辑及高通量功能基因组学，疾病与感染的分子机制。 研究方向： 着重发展和应用基因组编辑技术，涵盖编码及非编码序列的高通量功能基因组学、生物动态光学成像以及精准医疗。

近期论文

1. Zhou Z, and Wei W*. (2018). PrePAIRing Cas9s for screeninga success. Nat Biotechnol 36, 147-148. 2. Zhang H, Zhou Y, Wang Y, Zhao Y, Qiu Y, Zhang X, Yue D, Zhou Z, and Wei W*. (2018). A surrogate reporter system for multiplexable evaluation of CRISPR/Cas9 in targeted mutagenesis. Sci Rep 8, 1042. 3. Zhang Y, Liu L, Guo S, Song J, Zhu C, Yue Z, Wei W* and Yi C*. (2017) Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition. Nat Commun 8(1): 901. 4. Zhu S, Zhou Y and Wei, W* (2017). Genome-Wide CRISPR/Cas9 Screening for High-Throughput Functional Genomics in Human Cells. Methods Mol Biol 1656, 175-181. 5. He R, Peng J, Yuan P, Yang J, Wu X, Wang Y and Wei W*. (2017). Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest. Sci Rep 7(1): 10532. 6. Zhou Y, Wang P, Tian F, Gao G, Huang L*, Wei W* and Xie X.S* (2017) Painting A Specific Chromosome with CRISPR/Cas9 for Live-cell Imaging. Cell Res. 27, 298-301. 7. Hu H, Zhang H, Wang S, Ding M, An H, Hou Y, Yang X, Wei W*, Sun Y*, Tang C*. (2017) Live visualization of genomic loci with BiFC-TALE. Sci. Rep. 7, 40192. 8. Shawn Burgess, Linzhao Cheng*, Feng Gu, Junjiu Huang, Zhiwei Huang, Shuo Lin*, Jinsong Li, Wei Li, Wei Qin, Yujie Sun, Zhou Songyang, Wensheng Wei*, Qiang Wu, Haoyi Wang*, Xiaoqun Wang, Jing-Wei Xiong, Jianzhong Xi, Hui Yang, Bin Zhou, Bo Zhang. (2016) Questions about NgAgo. Protein & Cell doi:10.1007/s13238-016-0343-9. 9. Zhou Y, Zhang H and Wei W*. (2016) Simultaneous generation of multi-gene knockouts in human cells. FEBS Letters 590, 4343-4353. 10. Zhu S and Wei W*. (2016) Making better CRISPR libraries (Insight). eLife 5. 11. Zhu S, Li W, Liu J, Chen C-H, Liao Q, Xu P, Xu H, Xiao T, Cao Z, Peng J, Yuan P, Brown M, Liu X* & Wei W*. (2016) Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library. Nat Biotechnol 34, 1279-1286. 12. Zhou Y and Wei W*. (2016) Mapping regulatory elements. Nat Biotechnol 34, 151-152. 13. Peng J, Zhou Y, Zhu S and Wei W*. (2015) High-throughput Screens in Mammalian Cells Using the CRISPR-Cas9 System. FEBS Journal, 282, 2089–2096. 14. He R, Peng J, Yuan P, Xu F, Wei W*. (2015) Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. Autophagy, 11:5, 740-747. 15. Ren Q, Li C, Yuan P, Cai C, Luo G, Zhang L and Wei W*. (2015) A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus. Sci. Rep. 5, 8865. 16. Shen J, Cai C, Yu Z, Pang Y, Zhou Y, Qian L, Wei W* and Huang Y*. (2015) A microfluidic live cell assay to study anthrax toxin induced cell lethality assisted by conditioned medium. Sci. Rep. 5, 8651. 17. Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, He R, Li C, Guo S, Li S, Huang T, Feng H and Wei W*. (2015) Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. Cell Res. 25:157-168; published online 30 December 2014. 18. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W*. (2014) High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells. Nature 509: 487-91. 19. Qian LL, Cai CZ, Yuan PF, Jeong SY, Yang XZ, Almeida VD, Ernst J, Costa M, Cohen SN, Wei WS*. (2014) Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake. Sci China Life Sci 57: 469–481 (Cover). 20. Yang J, Zhang Y, Yuan P, Cai C, Ren Q, Guo S, Zhu C, Qi H and Wei W*. (2014) Complete Decoding of DNA Recognition by TAL Effector RVDs. Cell Res. 24:628-631. 21. Yang J, Yuan P, Wen D , Sheng Y, Zhu S, Yu Y, Gao X and Wei W*. (2013) ULtiMATE system for rapid assembly of customized TAL effectors. PLoS One 2013; 8:e75649.