个人简历

1989.9-1993.7 北京医科大学药学专业学习，获学士学位。2001.9-2003.7年于北京大学药剂学专业在职学习，获硕士学位。2005.9-2008.7年于中国科学院生物物理研究所在职学习，获博士学位。2011年于奥地利因斯布鲁克大学进修学习三个月。1993.8留校后进入北京医科大学药学院药剂学系从事教学和科研工作，主要承担本科生、研究生的药剂学、生物药剂学与药物动力学的理论课程与实验课程的教学工作。1998年聘为讲师，2009年聘为副教授。

研究领域

1.纳米技术增加难溶性药物及生物大分子药物跨生物屏障转运的机制；2. 肿瘤微环境响应型纳米药物递送系统的作用机制。

近期论文

1. Feiyang Deng, Hua Zhang, Xing Wang, Yuan Zhang, Hongxiang Hu, Siyang Song, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang*, and Qiang Zhang. Transmembrane Pathways and Mechanisms of Rod-like Paclitaxel Nanocrystals through MDCK Polarized Monolayer. ACS Appl. Mater. Interfaces. 2017, 9: 5803-5816. 2. Ye Li, Xiaoning Song, Xiang Yi, Ruibing Wang, Simon Ming-Yuen Lee, Xueqing Wang*, Ying Zheng*. Zebrafish: A Visual Model To Evaluate the Biofate of Transferrin Receptor-Targeted 7Peptide-Decorated Coumarin 6 Micelles. ACS Appl. Mater. Interfaces. 2017, 9, 39048-39058. 3. Yujie Shi, Zujin Shi, Suxin Li, Yuan Zhang, Bing He, Dong Peng, Jie Tian, Ming Zhao*, Xueqing Wang*, Qiang Zhang. The interactions of single-wall carbon nanohorns with polar epithelium. International Journal of Nanomedicine. 2017, 12, 4177–4194. 4. Nan Zheng#, Xing Wang#, Yaoqi Wang, Guobing Xu, Hua Zhang, Wenbing Dai, Bing He, Qiang Zhang, Jiafu Ji*, Xueqing Wang*. A sensitive liquid chromatography/electrospray tandem mass spectroscopy method for simultaneous quantification of a disulfide bond doxorubicin conjugation prodrug and activated doxorubicin: Application to cellular pharmacokinetic and catabolism studies. Journal of Chromatography B. 2017, 1065–1066, 96–103. 5. Yang Zhang, Xianhui Chen, Bo Zhao, Hounan Wu, Lan Yuan, Hua Zhang, Wenbing Dai, Bing He, Gengmei Xing, Qiang Zhang, Xueqing Wang*. Biosafety study and mechanism comparison on two types of silica with different nanostructures. Toxicology Research. 2017, 6, 487–498. 6. Yanan Cui, Suxin Li, Binlong Chen, Bing He, Lan Yuan, Wenbing Dai, Hua Zhang, Xueqing Wang*, and Qiang Zhang*. Serum Free or Not: Two Distinct Recycling Mechanisms Mediated by Alpha v Beta 3 Integrin. Curr Pharm Biotechnol. 2017, 18: 669-676. 7. 宋晓宁, 李 瑞, 张 华, 代文兵, 何 冰, 郑 颖, 张 强, 王学清*。pH 和靶头密度对FcBP 修饰的PEG-PCL 胶束在Caco-2 细胞上摄取与外排的影响。药学学报，2017, 52 (8): 1331-1336. 8. Qin Song, Xing Wang, Yaoqi Wang, Yanqin Liang, Yanxia Zhou, Xiaoning Song, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang*, and Qiang Zhang. Reduction responsive self-assembled nanoparticles based on disulfide-linked drug-drug conjugate with high drug loading and antitumor efficacy. Molecular Pharmaceutics. 2016, 13, 190-201. 9. Qin Song, Xingxing Chuan, Binlong Chen, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang*, and Qiang Zhang. A smart tumor targeting peptide-drug conjugate, pHLIP-SS-DOX: synthesis and cellular uptake on MCF-7 and MCF-7/Adr cells. Drug Delivery. 2016, 23(5):1734-1746. 10.Feiyang Deng, Chao Yu, Hua Zhang, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang*, Qiang Zhang. The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transportation in rats. Current Drug Delivery. 2016, 13, 105-110. 11. 李瑞, 宋晓宁, 张华, 代文兵, 何冰, 郑颖, 张强, 王学清*。FRET 技术研究PEG-PCL 胶束跨MDCK 细胞单层转运的完整性。药学学报, 2016, 51 (8): 1316-1324。 12. 串星星，印亚双，王学清*。还原响应型高载药量普朗尼克F127 聚合物胶束的制备。中国药房，2016, 27 (19): 2693-2696。 13. Xianhui Chen, Yang Zhang, Lan Yuan, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang*, Qiang Zhang. The P-glycoprotein inhibitory effect and related mechanisms of thiolated chitosan and its S-protected derivative. RSC Advances. 2015, 5, 104228–104238. 14.Hua Zhang, Hongxiang Hu, Haoran Zhang, Wenbing Dai, Xinglin Wang, Xueqing Wang* and Qiang Zhang*. Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis. Nanoscale. 2015, 7, 10790–10800. 15.Hua Zhang, Youyou Zhao, Xueqing Wang*, and Qiang Zhang. Bioavailability of tramadol hydrochloride after administration via different routes in rats. Biopharmaceutics & Drug Disposition. 2014, 35: 525–531. 16.Xingxing Chuan, Qin Song, Jialiang Lin, Xianhui Chen, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang*, and Qiang Zhang. Novel Free-Paclitaxel-Loaded Redox-Responsive Nanoparticles Based on a Disulfide-Linked Poly(ethylene glycol)？Drug Conjugate for Intracellular Drug Delivery: Synthesis, Characterization, and Antitumor Activity in Vitro and in Vivo. Molecular Pharmaceutics. 2014, 11, 3656-3670. 17.Xueqing Wang, Suxin Li, Yujie Shi, Xingxing Chuan, Ji Li, Ting Zhong, Hua Zhang, Wenbing Dai, Bing He, Qing Zhang*.The development of site-specific drug delivery nanocarriers based on receptor mediation. Journal of Controlled Release. 2014, 193: 139-153.