个人简历

教育经历\r
1994 - 1998 本科, 遗传学, 北京大学\r
1998 - 2003 博士, 细胞生物学, 北京大学\r
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荣誉奖励\r
2014年度中国科学十大进展（“利用极体高通量测序结果精确推演出母源基因组信息”）\r
2015年度中国科学十大进展（“揭示人类原始生殖细胞基因表达与表观遗传调控特征”）\r
2015年度中国生命科学领域十大进展\r
2019年度中国生命科学领域十大进展\r
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工作经历\r
2004 - 2010 英国剑桥大学Gurdon研究所，博士后\r
2010 - 现在 研究员, 北京大学生命科学学院生物医学前沿创新中心（BIOPIC）\r
2015 - 现在 研究员, 北大-清华生命科学联合中心\r
2017 - 现在 教授, 北京大学生命科学学院生物医学前沿创新中心（BIOPIC）

研究领域

""具有自我更新能力和分化潜能的干细胞是人类胚胎发育过程中以及成年个体生命活动中的关键类型的细胞，对各种干细胞进行深入研究是理解人类发育、生长机制的关键，也是将干细胞应用于临床再生医学、治疗人类疾病的前提。本实验室主要围绕人类早期胚胎发育研究多能干细胞的自我更新和多能性调控的分子机理，特别是表观遗传调控机理，以及相关的生殖系细胞发育过程中的表观遗传学重编程机理。利用我们发展的单细胞功能基因组学高通量测序技术体系（单细胞转录组测序技术、单细胞 DNA甲基化组测序技术、单细胞染色质状态组测序技术、单细胞多组学平行测序技术等），以及基因编辑技术、哺乳动物胚胎显微操作技术、器官小体（organoid）培养技术、以及人类胚胎干细胞体外定向分化等技术在单细胞和单碱基的极限分辨率下深入研究人类生殖系细胞发育、以及多能性干细胞分化过程中基因表达网络的表观遗传学调控机理。并在此基础上深入探索生殖细胞发育异常相关的不孕不育等疾病的分子机理和潜在的治疗策略""""

近期论文

Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH*, Tang Fuchou*, Qu J*. A single-cell transcriptomic landscape of primate arterial aging. Nature Communications, 11: 2202 (2020) (*: Co-corresponding authors).\r
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Hou S, Li Z, Zheng X, Gao Y, Dong J, Ni Y, Wang X, Li Y, Ding X, Chang Z, Li S, Hu Y, Fan X, Hou Y, Wen L, Liu B*, Tang Fuchou*, Lan Y*. Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses. Cell Research, 30: 376-392 (2020) (*: Co-corresponding authors).\r
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Chen Y, Lyu R, Rong B, Zheng Y, Lin Z, Dai R, Zhang X, Xie N, Wang S, Tang Fuchou*, Lan F*, Tong MH*. Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks. Cell Research, 30: 256-268 (2020) (*: Co-corresponding authors).\r
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Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Ma L, Esteban CR, Chan P, Qiao J, Zhou Q, Izpisua Belmonte JC*, Qu J*, Tang Fuchou*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell, 180: 585-600 (2020) (*: Co-corresponding authors).\r
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Zhang XM, Wu K, Zheng Y, Zhao H, Gao J, Hou Z, Zhang M, Liao J, Zhang J, Gao Y, Li Y, Li L, Tang Fuchou*, Chen ZJ*, Li J*. In vitro expansion of human sperm through nuclear transfer. Cell Research, 30: 356-359 (2019) (*: Co-corresponding authors).\r
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Wen L, Liu Q, Xu J, Liu X, Shi C, Yang Z, Zhang Y, Xu H, Liu J*, Yang H*, Huang H*, Qiao J*, Tang Fuchou*, Chen ZJ*. Recent advances in mammalian reproductive biology. Science China Life Sciences, 63: 18-58 (2019) (*: Co-corresponding authors).\r
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Li J, Wang R, Zhou X, Wang W, Gao S, Mao Y, Wu X, Guo L, Liu H, Wen L, Fu W*, Tang Fuchou*. Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis. Gut, doi: 10.1136/gutjnl-2019-319438 (2019)(*: Co-corresponding authors).\r
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Wen L*, Tang Fuchou*. Human Germline Cell Development: from the Perspective of Single-Cell Sequencing. Molecular Cell, 76: 320-328 (2019)(Review)(*: Co-corresponding authors).\r
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Yang X, Hu B, Liao J, Qiao Y, Chen Y, Qian Y, Feng S, Yu F, Dong J, Hou Y, Xu H, Wang R, Peng G*, Li J*, Tang Fuchou*, Jing N*. Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development. Cell Research, 29: 911-926 (2019) (*: Co-corresponding authors).\r
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Zhou F, Wang R, Yuan P, Ren Y, Mao Y, Li R, Lian Y, Li J, Wen L, Yan L, Qiao J*, Tang Fuchou*. Reconstituting the transcriptome and DNA methylome landscapes of human implantation. Nature, 572: 660-664 (2019) (*: Co-corresponding authors).\r
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Soares E, Xu Q, Li Q, Qu J, Zheng Y, Raeven HHM, Brandao KO, Petit I, van den Akker WMR, van Heeringen SJ, Aberdam D, Tang Fuchou*, Zhou H*. Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome. Proc Natl Acad Sci U S A, 116: 17361-17370 (2019) (*: Co-corresponding authors).\r
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Hu Y, Wang X, Hu B, Mao Y, Chen Y, Yan L, Yong J, Dong J, Wei Y, Wang W, Wen L, Qiao J*, Tang Fuchou*. Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis. PLoS Biology, 17: e3000365 (2019) (*: Co-corresponding authors).\r
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Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J*, Tang Fuchou*, Liu GH*. Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology, 17: e3000201 (2019) (*: Co-corresponding authors).\r
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Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J*, Tang Fuchou*, Liu GH*. Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Cell Reports, 26: 3643-3656 (2019) (*: Co-corresponding authors).\r
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Cui Y, Zheng Y, Liu X, Yan L, Fan X, Yong J, Hu Y, Dong J, Li Q, Wu X, Gao S, Li J, Wen L, Qiao J*, Tang Fuchou*. Single-cell transcriptome analysis maps the developmental track of the human heart. Cell Reports, 26: 1934–1950 (2019) (*: Co-corresponding authors).\r
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Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Izpisua Belmonte JC, Qu J*, Tang Fuchou*, Liu GH*. FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell, 24: 447-461 (2019) (*: Co-corresponding authors).\r
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Ji Q, Zheng Y, Zhang G, Hu Y, Fan X, Hou Y, Wen L, Li L, Xu Y, Wang Y*, Tang Fuchou*. Single-cell RNA-seq analysis reveals the progression of human osteoarthritis. Annals of the Rheumatic Diseases, 78: 100-110 (2019) (*: Co-corresponding authors).\r
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Bian S, Hou Y, Zhou X, Li X, Yong J, Wang Y, Wang W, Yan J, Hu B, Guo H, Wang J, Gao S, Mao Y, Dong J, Zhu P, Xiu D, Yan L, Wen L, Qiao J*, Tang Fuchou*, Fu W*. Single-cell multiomics sequencing and analyses of human colorectal cancer. Science, 362: 1060-1063 (2018) (*: Co-corresponding authors).\r
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Wang P, Chen Y, Yong J, Cui Y, Wang R, Wen L, Qiao J*, Tang Fuchou*. Dissecting the global dynamic molecular profiles of human fetal kidney development by single-cell RNA sequencing. Cell Reports, 24: 3554-3567 (2018) (*: Co-corresponding authors).\r
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Wang M, Liu X, Chang G, Chen Y, An G, Yan L, Gao S, Xu Y, Cui Y, Dong J, Chen Y, Fan X, Hu Y, Song K, Zhu X, Gao Y, Yao Z, Bian S, Hou Y, Lu J, Wang R, Fan Y, Lian Y, Tang W, Wang Y, Liu J, Zhao L, Wang L, Liu Z, Yuan R, Shi Y, Hu B, Ren X, Tang Fuchou*, Zhao XY*, Qiao J*. Single-cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis. Cell Stem Cell, 23: 599-614 (2018) (*: Co-corresponding authors).