研究领域
作为第二遗传密码，表观遗传通过对组蛋白和DNA的可遗传的修饰来调控基因的表达以及基因组的稳定等。表观遗传各种修饰酶活复合体导致多种多样的组蛋白和DNA的化学修饰，这些修饰以动态的、组合的方式来应答细胞各种信号来影响基因转录的活跃，休克和沉默。而基因的转录活动调控着细胞的各种重大生命活动，如增殖，凋亡，分化和衰老。本实验室主要研究表观遗传修饰控制基因转录的机制以及研究细胞衰老表观遗传修饰的动态变化和编程过程。
近期论文
Guoliang Lyu#, Yuting Guan# , Chao Zahng, Le Zong, Sun Lei, Xiaoke Huang. Li Huang, Lijun Zhang，Xiaoli Tian，Zhongjun Zhou and Wei Tao*.TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging. Nature Communications, 2018, doi:10.1038/s41467-018-04994-z Meng Chen#, Guoliang Lyu#, Miao Han#, Hongbo Nie#, Ting Shen, Wei Chen, Yichi Niu, Yifan Song, Xueping Li, Huan Li, Xinyu Chen, Ziyue Wang, Zheng Xia, Wei Li, Xiao-Li Tian, Chen Ding, Jun Gu, Yufang Zheng, Xinhua Liu, Jinfeng Hu, Gang Wei*, Wei Tao*, Ting Ni.* 3′ UTR lengthening as a novel mechanism in regulating cellular senescence. Genome Research, 2018, 28: 285-294 Guoliang Lyu, Chao Zhang, Te Ling, Rui Liu, Le Zong, Yiting Guan, Xiaoke Huang, Lei Sun, Lijun Zhang, Cheng Li*, Yu Nie* and Wei Tao*. Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease. BMC Genomics, 2018 19:428 Min Luo#, Te Ling#, WenbingXie#, He Sun, Yonggang Zhou, Qiaoyun Zhu, Meili Shen, Le Zong, Yun Zhao, Tao Ye, Jun Gu, Wei Tao*, Zhigang Lu*, Ingrid Grummt*. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells, 2013, 31:1278-86. Guoliang Lyu, Le Zong, Chao Zhang, Xiaoke Huang, Wenbing Xie, Junnan Fang, Yiting Guan, Lijun Zhang, Ting Ni#, Jun Gu#, Wei Tao# . Metastasis-related methyltransferase Merm1 represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation. Journal of Molecular Cell Biology, 2018, doi:10.1093/jmcb/mjy023 Ling T, Xie W, Luo M, Shen M, Zhu Q, Zong L, Zhou T, Gu J, Lu Z, Zhang F, Tao W* , CHD4 maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5 , Biochem Biophys Res Commun, 2013, 19:101-107 Xie W, Ling T, Zhou Y, Feng W, Zhu Q, Stunnenberg HG, Grummt I*, Tao W* , The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions, PNAS, 2012, 109:8161-8166 Guanghliang LV, Tan Tan, Zong L, Yuting Guan， Lei Sun, Liang QJ* and Tao W*, Changes in the position and volume of inctive X Chromosomes during G0/G1 trnasition, Chromosome Research, 2018, 26：179-189
