个人简历

教育经历: 2001-2006, 理学博士, 分子遗传学, 杜克大学 1996-2000, 理学学士, 细胞遗传, 北京大学 工作经历: 2012/11-现在，研究员, 北京大学生命科学学院 2018/11-现在，研究员，北大-清华生命科学联合中心 (CLS) 2012/11-2018/11，青年学者, 北大-清华生命科学联合中心 (CLS) 2011-2012, Research associate, 病理学系, 斯坦福大学 2006-2011, 博士后, 病理学系, 斯坦福大学

研究领域

我们实验室致力于研究正常干细胞和癌症干细胞的自我复制，迁移及分化的细胞分子机制。干细胞就像一柄双刃剑：一方面，干细胞的有效利用为再生医学提供了希望；另一方面，干细胞调控的紊乱可导致癌症等多种人类疾病。由于正常干细胞和癌症干细胞极为相似，如何特异性得去除癌症干细胞从而达到抑制肿瘤发生的目的，同时又不损伤正常干细胞是干细胞及癌症领域一个极大的挑战。组织损伤后，干细胞如何被诱导，迁移至伤口处并及时分化成正确的体细胞以达到组织修复的效果是再生医学一个重大的问题。我们利用新颖的研究干细胞致瘤及干细胞迁移的果蝇模型，并结合遗传学，细胞生物学，生化及体内动态成像等多种手段研究以下几个问题：1) 正常干细胞在其组织或器官中是如何被长期维持的？正常干细胞和癌症干细胞在自我复制，迁移及分化等方面有何本质区别？2) 在发育过程中及组织损伤后，干细胞是如何感知信号并进行有方向性，实效性的迁移行为的？诱导因子是什么？信号是如何被长距离传导的？由于我们在相对简单的果蝇干细胞模型中发现的细胞分子机制很可能是非常保守的，我们的研究结果将为人类癌症防治和组织再生提供重要的理论基础。

近期论文

1. Li B.#, Wong C.#, Gao S.M., Zhang R., Sun R., Li Y. and Song Y.* (2018) The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. Elife 2018;7;e38181 DOI: 10.7554/eLife.38181 Press release by Elife: https://elifesciences.org/for-the-press/3d24b574/body-s-own-bomb-squad-can-help-protect-against-brain-tumors 2. Xu K., Liu X., Wang Y., Wong C. and Song Y.* (2018) Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming. Elife 2018;7:e33934 DOI: 10.7554/eLife.33934 3. Jing M., Zhang P., Wang G., Jiang H., Mesik L., Feng J., Wang S., Looby J., Guagliardo N.A., Langma L.W., Lu J., Zuo Y., Talmage D.A., Role L.W., Barrett P.Q., Zhang L.I., Luo M., Song Y., Zhu J.* and Li Y.* (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology 36:726–737 4. Liu K., Shen D., Shen J., Gao S.M., Li B., Wong C., Feng W. and Song Y.* (2017) The super elongation complex drives neural stem cell fate commitment. Developmental Cell, 40(6), 537-551 [Cover article]. Highlighted in Developmental Cell: Rossi A.M. and Desplan C.* (2017) Asymmetric Notch Amplification to Secure Stem Cell Identity. Developmental Cell, 40(6), 513-514. Recommended by F1000Prime: https://f1000.com/prime/727458399 5. Liu K., Xu K. and Song Y.* (2019) Faster, Higher, Stronger: Timely and robust cell fate/identity commitment in stem cell lineages. Open Biology, 9: 180243. [Invited review] 6. Wu Y.C., Lee K.S., Song Y., Gehrke S., Lu B.* (2017) The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain. PLoS Genetics, 13(5):e1006785. 7. Lee K.S.#, Wu Z.#, Song Y., Mitra S.S., Feroze A.H., Cheshier S.H., Lu B.* (2013) Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway. Genes & Development, 27(24):2642-7 [Cover article] 8. Song Y. and Lu B.* (2012) Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells. Journal of Biological Chemistry, 287(21):17716-28. 9. Ouyang Y.#, Song Y.# and Lu B.* (2011) dp53 restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and Cyclin E. PLoS ONE, 6(11):e28098 (# contribute equally). 10. Song Y. and Lu B.* (2011) Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila. Genes & Development, 25(24):2644-2658. 11. Yu L., Song Y. and Wharton R.P.* (2010) E(nos)/CG4699 required for nanos function in the female germ line of Drosophila. Genesis, 48(3):161-70. [Cover article] 12. Song Y., Fee L., Lee T. and Wharton R.P.* (2007) The molecular chaperone Hsp90 is required for mRNA localization in Drosophila melanogaster embryos. Genetics, 176(4):2213-22.