个人简历

2016.07-至今，研究员，北京大学化学与分子工程学院 \r
2016.07-至今，中心研究员，北大-清华生命科学联合中心 \r
2014.09–2016.07，博士后研究员，美国国立卫生研究院 \r
2010.09–2014.09，博士，英属哥伦比亚大学化学系 \r
2011.05–2014.09，跨学科博士培养项目，TRIUMF原子能国家实验室 \r
2012.03–2014.09，跨学科博士培养项目，英属哥伦比亚肿瘤中心 \r
2010.06，理学学士，南京大学化学化工学院化学系

研究领域

""以B-F键为基础的18F通用标记法\r
以三氟化硼（-BF3-）与羧酸根（-COO-）的相似性为基础的化学生物学研究\r
以炎症特异性的放射性探针为基础，采用PET影像支持临床中癌症与炎症的鉴别\r
以硼中子捕获治疗（BNCT）为基础的癌症诊疗一体化平台""""

近期论文

Xi-Yang Cui, Yu Liu, Changlun Wang, Zihao Wen, Yichen Li, Haocheng Tang, Juan Diwu, Yuchuan Yang, Mengchao Cui, Zhibo Liu*. China's Radiopharmaceuticals on Expressway: 2014-2021. Radiochimica Acta, 2022, https://doi.org/10.1515/ract-2021-1137.\r
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Zexuan Ding, Zhibin Guo, Yuedan Zheng, Ziyang Wang, Qunfeng Fu, and Zhibo Liu*. Radiotherapy reduces N-oxides for prodrug activation in tumors. J Am Chem Soc, 2022, doi: 10.1021/jacs.2c02521\r
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Ziren Kong #, Zhu Li #, Junyi Chen #, Wenbin Ma, Yu Wang*, Zhi Yang*, Zhibo Liu*, Larger 18F-fluoroboronotyrosine (FBY) active volume beyond MRI contrast enhancement in diffuse gliomas than in circumscribed brain tumors, EJNMMI Res, 2022, 12(1):22. \r
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Jiyuan Li#, Qi Sun#, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu, Zhibo Liu*, Boron encapsulated in a liposome can be used for combinational neutron capture therapy, Nat Commun, 2022, 13: 2143.\r
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Junyi Chen, Jingfeng Wang, MengXin Xu, Xianlu Jia, Guofang Song, Zhibo Liu*, Production of positron-emitting radionuclide yttrium-86 with a computer-aided design target for positron emission tomography, Nucl Med Biol, 2022, 108-109:54-60.\r
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Junyi Chen, Mengxin Xu, Yu Liu, Dongban Duan, Yuxiang Han, Zhibo Liu*, Isolation of 212Pb from natural thorium for targeted alpha-therapy, Chin Chem Lett, 2022, doi: doi.org/10.1016/j.cclet.2022.02.012\r
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Ziren Kong#, Zhu Li#, Junyi Chen#, Sirui Liu, Delin Liu, Jiyuan Li, Nan Li, Wenbin Ma, Feng Feng, Yu Wang*, Zhi Yang*, Zhibo Liu*, Metabolic characteristics of [18F] fluoroboronotyrosine (FBY) PET in malignant brain tumors, Nucl Med Biol, 2022, 106-107:80-87.\r
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Pu Zhang#, Mengxin Xu#, Jie Ding, Junyi Chen, Taiping Zhang, Li Huo*, Zhibo Liu*，Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy, Eur J Nucl Med Mol Imaging, 2021, 49, 1985–1996.\r
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Huifang He, Jiyuan Li, Ping Jiang, Suqing Tian, Hao Wang, Ruitai Fan, Junqi Liu, Yuyan Yang, Zhibo Liu*, Junjie Wang*, The basis and advances in clinical application of boron neutron capture therapy, Radiat Oncol, 2021, 16(1):216.\r
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Mengxin Xu, Pu Zhang, Jie Ding, Junyi Chen, Li Huo, Zhibo Liu*, Albumin Binder–Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy. J Nucl Med, 2021, doi: 10.2967/jnumed.121.262533.\r
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Junyi Chen, Yinlong Lv, Feng Wang, Tianjue Zhang, Zhibo Liu*, Production and isolation of actinium-225 with a 100 MeV proton cyclotron and solid-phase extraction for targeted radiotherapy. Chemistry (HXTB), 2021, 84(11):1211-1219.\r
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Chunhong Wang, Hanyu Hong, Mengqi Chen, Zexuan Ding, Yuchen Rui, Zi-Chen Li,Zhibo Liu*, A Cationic Micelle as In Vivo Catalyst for Tumor-Localized Cleavage Chemistry. Angew Chem Int Ed, 2021,60, 19750-19758\r
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Zhu Li#, Ziren Kong#, Junyi Chen, Jiyuan Li, Nan Li, Zhi Yang*,Yu Wang*, Zhibo Liu*, 18F-Boramino Acid PET/CT in Healthy Volunteers and Glioma Patients. Eur J Nucl Med Mol Imaging, 2021, 48(10):3113-3121.\r
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Dongban Duan, Hao Dong, Zhiyu Tu, Chunhong Wang, Qunfeng Fu, Junyi Chen, Hai-peng Zhong, Ping Du, Ling-Dong Sun, Zhibo Liu*, Desilylation Induced by Metal Fluoride Nanocrystals Enables Cleavage Chemistry In Vivo. J Am Chem Soc, 2021,143(5):2250-2255.\r
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Jingyun Ren, Mengxin Xu, Junyi Chen, Jie Ding, Peipei Wang, Li Huo*, Fang Li*, Zhibo Liu*, PET Imaging Facilitates Antibody Screening for Synergistic Radioimmunotherapy with A 177Lu-Labeled αPD-L1 Antibody. Theranostics, 2021,11(1):304-315.\r
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Liping Li, Kun Dai, Jiyuan Li, Yaxin Shi, Zizhu Zhang, Tong Liu, Ruiping Zhang*, Zhibo Liu*, A Boron-10 Nitride Nanosheet for Combinational Boron Neutron Capture Therapy and Chemotherapy of Tumor. Biomaterials, 2021,268:120587.\r
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Yaxin Shi, Qiang Fu, Jiyuan Li, Zizhu Zhang, Hui Liu, Tong Liu, Zhibo Liu*, A Covalent Organic Polymer as a Carborane Carrier for Imaging-Facilitated Boron Neutron Capture Therapy, ACS Appl Mater Interfaces​,2020, 12(50): 55564−55573.\r
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Jiyuan Li, Zhiyu Tu, Zhibo Liu*, 走进曙色的冷门方向 ：硼携带剂发展历程简述, Scientia Sinica Chimica, 2020, 50: 1296–1319.\r
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Qunfeng Fu, Hongyu Li, Dongban Duan, Changlun Wang, Huimin Ma, Zhibo Liu*, External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors, Angew Chem Int Ed, 2020, 59(48): 21546–21552.\r
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Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*, A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426.