个人简历
1986年在山东大学化学系获得理学学士学位。1989年在山东大学化学系获得理学硕士学位。同年8月到北京医科大学药学院工作。1998-2000年到德国雷根斯堡大学化学与药学系工作与学习。2000年至今，任北京大学药学院药剂学系副教授。讲授物理化学、物理药剂学和分散体系的物理化学等本科、硕士和博士研究生课程。担任《化学学报》、《药学学报》、《中国药学杂志》、《中国新药杂志》、Biomaterials、Acta Biomaterialia、Biomacromolecules、Molecular Pharmaceutics、International Journal of Pharmaceutics、Pharmaceutical Research等多个学术期刊的评审。主持或参加的基金项目包括国家自然科学基金、973重大研究计划、国家重大新药创制专项新剂型与新释药系统技术平台等。在国内、外学术期刊上发表论文80余篇。主编教材或专著6部，主译专著1部，参编教材4部。获得国家发明专利9项。主持完成了数个药物制剂的研究开发工作。
研究领域
物理药剂学。主要涉及以下研究领域 1. 新型纳米载体系统与靶向给药 2. 功能高分子材料与智能释药系统 3. 药物多晶型
近期论文
1.Xiaoyou Qu, Yang Zou, Yuanhang Zhou, Yan Liu*, et al. Self-assembled nanoparticles from vitamin E succinate-based amphiphilic polymers for effective intestinal delivery of paclitaxel and their transcellular transport mechanisms and intracellular trafficking routes. Drug Delivery , 2018, 25(1):210-225. 2. Dishi Wang, Yanxia Zhou, Xinru Li, Yan Liu*, et al. Mechanisms of pH-sensitivity and cellular internalization of PEOz-b-PLA micelles with varied hydrophilic/hydrophobic ratios and intracellular trafficking routes and fate of the copolymer. ACS Applied Materials and Interfaces, 2017,9:6916-6930. 3. Ziqi Wang, Xinru Li, Dishi Wang, Yan Liu*, et al. Concurrently suppressing multidrug resistance and metastasis of breast cancer by co-delivery of paclitaxel and honokiol with polymeric micelles. Acta Biomaterialia , 2017, 62:144-156. 4. Xiaoyou Qu, Yang Zou, Yuanhang Zhou, Yan Liu*, et al. Preparation and characterization of pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-vitamin E succinate for paclitaxel delivery. Journal of Chinese Pharmaceutical Sciences . 2017, 26(8): 582-588. 5. Yajie Gao, Yanfang Li, Yushu Li, Yan Liu*, et al. PSMA-mediated endosome escape-accelerating polymeric micelles for targeted therapy ofprostate cancerand the real time tracing of their intracellular trafficking. Nanoscale , 2015, 7(2):597-612. 6. Jinwen Li, Yanxia Zhou, Chengwei Li, Yan Liu*, et al. Poly(2-ethyl-2-oxazoline)-doxorubicin conjugate-based dual endosomal pH-sensitive micelles with enhanced antitumor efficacy. Bioconjugate Chemistry , 2015, 26(1):110-119. 7. Yong Zhao, Yanxia Zhou, Dishi Wang, Yan Liu*, et al. pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) for tumor-targeting and controlled delivery of doxorubicin and P-gp inhibitor. Acta Biomaterialia , 2015,17:182-192. 8. Yajie Gao, Chao Zhang, Yanxia Zhou, Yan Liu*, et al. Endosomal pH-responsive polymer-based dual-ligand-modified micellar nanoparticles for tumor targeted delivery and facilitated intracellular releaseof paclitaxel. Pharmaceutical Research , 2015, 32(8):2649-2662. 9. Lei Zhao, Yanxia Zhou, Yajie Gao, Yan Liu*, et al.Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. International Journal of Pharmaceutics , 2015, 483:180-187. 10. Yajie Gao, Yanxia Zhou, Lei Zhao, Yan Liu*, et al. Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles. Acta Biomaterialia , 2015, 23:127-135. 11. Wenjing Li, Xinru Li, Yajie Gao, Yan Liu*, et al. The Inhibition Mechanism of P-glycoprotein Mediated Efflux by mPEG-PLA and Influence of PLA Chain Length on P-glycoprotein Inhibition Activity. Molecular Pharmaceutics, 2014,11:71-80. 12. Chao Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Enhancedtopical delivery of tetrandrine by ethosomes for treatment of arthritis. Journal of Biomedicine and Biotechnology , 2013, Article ID 161943. 13. Na Li, Xinru Li, Yanxia Zhou, Yan Liu*, et al. The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier. Biomaterials , 2012, 33(34):8881-8892. 14. Guiling Li, Yating Fan, Xinru Li, Yan Liu*, et al. In vitro and in vivo evaluation of a simple microemulsion formulation for propofol. International Journal of Pharmaceutics , 2012, 425:53–61. 15. Guiling Li, Chao Fan, Xinru Li, Yan Liu*, et al. Preparation and in vitro evaluation of tacrolimus loaded ethosomes. The Scientific World Journal , 2012, Article ID 874053.
