个人简历

简介
　　刘启昆，博雅青年学者。刘启昆于2008年获得复旦大学学士学位，2014年获得美国宾夕法尼亚州立大学博士学位，2014年9月至2019年6月在美国加利福尼亚大学洛杉矶分校开展博士后研究，2019年7月回国，任职于北京大学现代农学院。
　　实验室主要从事植物表观遗传学领域相关的研究工作。DNA的甲基化修饰是植物调控基因表达的重要机制。通常情况下，基因和转座子的表达活性受到DNA甲基化的强烈抑制。然而，在特定的遗传背景和环境胁迫下，带有甲基化修饰的基因会逃脱监控产生转录活性。我们对基因和转座子如何逃脱DNA甲基化的抑制效应极为感兴趣。结合基因组学，遗传学和细胞生物学的手段，我们希望能进一步阐明此现象的分子机制和生物学意义。
　　

近期论文

科研论文：
1. Liu, Q.*, Bischof, S.*, Harris, C.J., Zhong, Z., Zhan, L., Nguyen, C., Rashoff, A., Barshop, W.D., Sun, F., Feng, S., et al.(2020). The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis. Nat Commun11, 2798. *co-first author
2. Chen, M., Liu, Q., Gao, S.S., Young, A.E., Jacobsen, S.E., and Tang, Y. (2019). Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant. Proc Natl Acad Sci U S A116, 5499-5504.
3. Yan, Y., Liu, Q., Jacobsen, S.E., and Tang, Y. (2018a). The impact and prospect of natural product discovery in agriculture: New technologies to explore the diversity of secondary metabolites in plants and microorganisms for applications in agriculture. EMBO Rep19.
4. Yan, Y.*, Liu, Q.*, Zang, X.*, Yuan, S., Bat-Erdene, U., Nguyen, C., Gan, J., Zhou, J., Jacobsen, S.E., and Tang, Y. (2018b). Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. Nature559, 415-418. *co-first author
5. Zhang, Y.*, Harris, C.J.*, Liu, Q.*, Liu, W., Ausin, I., Long, Y., Xiao, L., Feng, L., Chen, X., Xie, Y., et al.(2018). Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in Arabidopsis. Proc Natl Acad Sci U S A115, E1069-E1074. *co-first author
6. Coruh, C., Cho, S.H., Shahid, S., Liu, Q., Wierzbicki, A., and Axtell, M.J. (2015). Comprehensive Annotation of Physcomitrella patens Small RNA Loci Reveals That the Heterochromatic Short Interfering RNA Pathway Is Largely Conserved in Land Plants. Plant Cell27, 2148-2162.
7. Liu, Q., and Axtell, M.J. (2015). Quantitating plant microRNA-mediated target repression using a dual-luciferase transient expression system. Methods Mol Biol1284, 287-303.
8. Brousse, C., Liu, Q., Beauclair, L., Deremetz, A., Axtell, M.J., and Bouche, N. (2014). A non-canonical plant microRNA target site. Nucleic Acids Res42, 5270-5279.
9. Liu, Q., Wang, F., and Axtell, M.J. (2014). Analysis of complementarity requirements for plant microRNA targeting using a Nicotiana benthamiana quantitative transient assay. Plant Cell26, 741-753.