研究领域
细胞表面受体是全球60%药物的靶标。本课题组长期致力于细胞表面受体的分子与结构药理学研究：以结构生物学技术为重要手段，结合分子生物学、生物化学和生物物理学的技术和方法，在原子分辨率水平上揭示肿瘤转移和自闭症谱系障碍（Autism Spectrum Disorders, ASD）等神经精神性疾病相关的细胞表面受体跨膜信号转导的结构机制，阐明它们功能异常以及导致疾病的分子基础；基于结构发现调节它们功能的分子工具（包括单克隆抗体），试图确证新的药物靶标，或者解决耐药性等药理学问题。
近期论文
1. Lin Z, Liu J, Ding H, Xu F, Liu H#.Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation. Nat Commun . 2018 Jan 18;9(1):268. (# Corresponding author) 2. Bu Q, Li Z, Zhang J, Xu F, Liu J, Liu H#.The crystal structure of full-length Sizzled from Xenopus laevis yields insights into Wnt-antagonistic function of secreted Frizzled-related proteins. J Biol Chem . 2017 Sep 29;292(39):16055-16069. 3. Jiang X, Fischer D, Chen X, McKenna SD, Liu H, Sriraman V, Yu HN, Goutopoulos A, Arkinstall S, He X.Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. J Biol Chem . 2014 289(20): 14273–82 4. Liu Heli, Leo C, Chen X, Wong BR, Williams LT, Lin H, He X. The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1. Biochim Biophys Acta . 2012 1824(7):938-45 5. Jiang X, Liu Heli, Chen X, Chen PH, Fischer D, Sriraman V, Yu HN, Arkinstall S, He X. Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor. Proc Natl Acad Sci U S A . 2012 109(31):12491-6 6. Heli Liu, Pamela J. Focia, Xiaolin He.Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules. J Biol Chem . 2011 286(1):797-805 7. Heli Liu, Z. Sean Juo, Ann Hye-Ryong Shim, Pamela J. Focia, Xiaoyan Chen, K. Christopher Garcia, and Xiaolin He. Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1. Cell . 2010 142(5):749-61. (recommended by “Faculty of 1000”) 8. Ann H. R. Shim*, Heli Liu*, Pamela J. Focia, Xiaoyan Chen, P. Charles Lin, Xiaolin He. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proc Natl Acad Sci U S A . 2010 107(25):11307-12. (*equal contribution) 9. Heli Liu, Ann H. R. ShimXiaolin He.Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function. J Biol Chem . 2009 284(42):29077-86. (highlighted as “Paper of Week”) 10. Chen X, Liu Heli, Focia PJ, Shim AH, He X. Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. Proc Natl Acad Sci U S A . 2008 105(47):18267-72. 11. Xiaoyan Chen, Heli Liu, Ann Shim, Pamela J Focia, Xiaolin He. Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions. Nature Structural & Molecular Biology . 2008 15(1):50-6 12. Heli Liu*, Xiaoyan Chen*, Pamela J Focia, Xiaolin He.Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases. EMBO J . 2007 26(3):891-901 (*equal contribution) [commented in Cell. 2007 Jul 27;130(2):213-5]
