个人简历

EDUCATION\r
2002-2007 Ph.D in Chemistry (2007) University of Chicago Chicago, USA\r
1998-2002 B.S. in Chemistry, Peking University Beijing, China\r
1999-2002 B.S. Double degree in Economics, Peking University Beijing, China\r
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ACADEMIC POSITIONS\r
2019/03-present, Associate Editor, ACS Chemical Biology\r
2018/01-present, Cheung Kong Professor, Ministry of Education, P.R.China\r
2016/01-present, Senior Investigator, Peking-Tsinghua Center for Life Science\r
2015/01-present, Chairman, Department of Chemical Biology, Peking University\r
2014/08-present, Professor, Department of Chemical Biology, Peking University\r
2011/05-2015/12, Investigator, Peking-Tsinghua Center for Life Sciences\r
2009/07-2014/07, Investigator, Department of Chemical Biology, College of Chemistry, Peking University\r
2007-2009, Postdoctoral Fellow, The Scripps Research Institute, Advisor: Prof. Peter G. Schultz\r
2002-2007, Research Assistant, The University of Chicago, Chicago. Advisor: Prof. Chuan He

研究领域

"""""Our group works at the Chemistry-Biology Interface. Current efforts are focused on developing and applying bioorthogonal cleavage chemistry to study protein functions and protein-protein interactions in living systems. We also exploit the therapeutic potential of these novel reactions. Research directions we are actively pursuing include:\r
Protein bioorthogonal chemistry\r
Protein therapeutic engineering\r
Chemical Immunology"

近期论文

Wang J, Liu Y, Liu Y, Zheng S, Wang X, Zhao J, Yang F, Zhang G, Wang C*, Chen P*. “Time-resolved protein activation by proximal decaging in living systems”，Nature. (2019), 569, 509–513.\r
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Ge Y, Chen L, Liu S, Zhao J, Zhang H, Chen P*. “Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions”，J. Am. Chem. Soc. (2019), 141, 1833-37.\r
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Zhao J, Liu Y, Lin F, Wang W, Yang S, Ge Y, Chen P*. “Bioorthogonal Engineering of Bacterial Effectors for Spatial–Temporal Modulation of Cell Signaling”, ACS Cent. Sci. (2019), 5, 145-53.\r
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He D, Zhang M, Liu S, Xie X, Chen P*. “Protease-mediated protein quality control for bacterial acid resistance”, Cell Chem. Biol. (2019), 26,144-50.\r
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Yao Q, Lin F, Fan X, Wang Y, Liu Y, Liu Z, Jiang X, Chen P*，Gao Y*. “Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems”, Nat. Commun. (2018), 9, 5032.\r
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Hao Z, Zhu R, Chen P*. “Genetically encoded fluorescent sensors for measuring transition and heavy metals in biological systems”, Curr. Opin. Chem. Biol. (2018), 43, 87-96.\r
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Ngai WSC, Chen P*. “Optimizing orthogonality”, Nat Chem. (2018), 10, 802-3.\r
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Liu L, Liu Y, Zhang G, Ge Y, Fan X, Lin F, Wang J, Zheng H, Xie X, Zeng X, Chen P*. “Genetically encoded chemical decaging in living bacteria”, Biochemistry. (2018),57, 446-50.\r
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Zheng H, Lin S, Chen P*. “Genetic code expansion in enteric bacterial pathogens”, Methods Mol Biol. (2018), 1728, 113-26.\r
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R. Zhu, Y. Song, H. Liu, Y. Yang, S. Wang, C. Yi, Chen P*. “Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation”，Proc. Natl. Acad. Sci. (2017), 114, 13661-6.\r
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He D, Xie X, Yan F, Zhang H, Su H, Ge Y, Song H, Chen P*. “Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker”，Angew. Chem. Int. Ed. DOI: 10.1002/anie.201708151\r
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Yang Y, Song H, He D, Zhang S, Dai S, Xie X, Lin S, Hao Z, Zheng H, Chen P*. “Genetically encoded releasable photo-cross-linking strategies for studying protein–protein interactions in living cells”，Nat. Protoc. (2017), 12, 2147–2168\r
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Zheng S, Fan X, Wang J, Zhao J, Chen P*. “Dissection of Kinase Isoforms through Orthogonal and Chemical Inducible Signaling Cascades”，ChemBioChem (2017), 18, 1-7\r
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Zhang S, He D, Lin Z, Yang Y, Song H, Chen P*. “Conditional Chaperone–Client Interactions Revealed by Genetically Encoded Photo-cross-linkers”，Acc. Chem. Res. (2017), 50, 1184–1192\r
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Xie X, Li X, Qin F, Lin J, Zhang G, Zhao J, Bao X, Zhu R, Song H, Li X, Chen P*. “Genetically Encoded Photoaffinity Histone Marks”，J. Am. Chem. Soc. (2017), 139, 6522–6525\r
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Zhu R, Hao Z, Lou H, Song Y, Zhao J, Chen Y, Zhu J, Chen P*. “Structural characterization of the DNA-binding mechanism underlying the copper(II)-sensing MarR transcriptional regulator”, J. Biol. Inorg. Chem.(2017), 22，685–693\r
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Lin Z, Xie X,Chen P*. “Kicking down the ladder: adding cleavable features to genetically encoded photocrosslinkers”，Sci. China Chem. (2017), 60, 167–169\r
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Wang J, Zheng S, Liu Y, Zhang Z, Lin Z, Li J, Zhang G, Wang X, Li J and Chen P*. “Palladium-triggered chemical rescue of intracellular proteins via genetically encoded allene-caged tyrosine”, J. Am. Chem. Soc. (2016), 138, 15118−15121\r
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Fan X, Ge Y, Lin F, Yang Y, Zhang G, Ngai WSC, Lin Z, Zheng S, Wang J, Zhao J, Li J and Chen P*. “Optimized Tetrazine Derivatives for Rapid Bioorthogonal Decaging in Living Cells”, Angew. Chem. Int. Ed. (2016), 55, 14046-50.\r
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Yang Y, Song H and Chen P*. “Genetically encoded photocrosslinkers for identifying and mapping protein-protein interactions in living cells”, IUBMB life (2016), 68, 879-86.