个人简历

2017 – 至今 北大-清华生命科学联合中心 高级研究员\r
2016 – 至今 北京大学化学与分子工程学院 教授\r
2011 – 至今 北京大学合成与功能生物分子中心 研究员\r
2011 – 2017 北大-清华生命科学联合中心 研究员\r
2010 – 2016 北京大学化学与分子工程学院 研究员\r
2007 – 2010 哈佛大学医学院 博士后\r
2007 加州大学伯克利分校 化学博士\r
2002 清华大学 化学学士

研究领域

"""""化学与生命科学的交叉融合为分析、理解和操控生物学过程开辟了一条全新的研究途径。我们课题组的研究兴趣集中于化学糖生物学和生物纳米技术。我们综合运用化学方法、生物手段和纳米技术，研究糖基化的生物学功能及其在代谢疾病及其心血管并发症中的作用\r
主要研究内容包括\r
活细胞及活体中聚糖的化学标记\r
糖的合成、成像和组学分析\r
糖基化在神经系统和干细胞中的功能\r
糖代谢与糖基化的内在联系\r
基于生物正交反应的化学生物学技术"

近期论文

Sun, D.; Fan, X.; Zhang, H.; Huang, Z.; Tang, Q.; Li, W.; Bai, J.; Lei, X.; Chen, X.* “ Click-ExM enables expansion microscopy for all biomolecules” bioRxiv DOI: 10.1101/2020.03.19.998039.\r
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Qin, K; Zhang, H.; Zhao, Z.; Chen, X.* “ Protein S-Glyco-Modification Through an Elimination-Addition Mechanism” J. Am. Chem. Soc. DOI: 10.1021/jacs.0c02110.\r
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Liu, C.; Shi, Y.; Li, J.; Liu, X.; Xiahou, Z.; Tan, Z.; Chen, X.; Li, J.* “ O-GlcNAcylation of Myosin Phosphatase Targeting Subunit 1 (MYPT1) Dictates Timely Disjunction of Centrosomes” J. Biol. Chem. DOI: 10.1074/jbc.RA119.012401.\r
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Qin, W.; Xie, Z.; Wang, J.; Ou, G.; Wang, C.*; Chen, X.* “ Chemoproteomic Profiling of O-GlcNAcylation in Caenorhabditis elegans” Biochemistry DOI: 10.1021/acs.biochem.9b00622.\r
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Cheng, B.; Dong, L.; Zhu, Y.; Huang, R.; Sun, Y.; You, Q.; Song, Q.; Paton, J.C.; Paton, A.W.; Chen, X.* “ 9-Azido Analogs of Three Sialic Acid Forms for Metabolic Remodeling of Cell-Surface Sialoglycans” ACS Chem. Biol. 14, 2141(2019).\r
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Hao, Y.; Fan, X.; Shi, Y.; Zhang, C.; Sun, D.; Qin, K.; Qin, W.; Zhou, W.; Chen, X.* “ Next-Generation Unnatural Monosaccharides Reveal that ESRRB O-GlcNAcylation Enhances Pluripotency of Mouse Embryonic Stem Cells” Nat. Comm. 10, 4065 (2019).\r
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Qin, W.; Qin, K.; Zhang, Y.; Jia, W.; Chen, Y.; Cheng, B.; Peng, L.; Chen, N.; Liu, Y.; Zhou, W.; Wang, Y.; Chen, X.*; Wang, C.* “ S-Glycosylation-Based Cysteine Profiling Reveals Negative-Feedback Regulation of Glycolysis by Itaconate.” Nat. Chem. Biol. 15, 983-991 (2019).\r
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Wang, W.; Lin, L.; Du, Y.; Song, Y.; Peng, X.; Chen, X.*; Yang, J. C.* “ Assessing the Viability of Transplanted Gut Microbiota by Sequential Tagging with D-Amino Acid-Based Metabolic Probes.” Nat. Comm. 10, 1317 (2019).\r
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Li, Y.; Liu, W.; Tang, Q.; Fan, X.; Hao, Y.; Gao, L.; Li, Z.; Cheng, B.; Chen, X.* “ Gap-Junction-Dependent Labeling of Nascent Proteins in Multicellular Networks.” ACS Chem. Biol. 14, 182-185 (2019).\r
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Gao, L.; Song, Q.; Liang, H.; Zhu, Y.; Wei, T.; Dong, N.; Xiao, J.; Shao, F.; Chen, X.* “ Legionella Effector SetA as A General O-glucosyltransferase for Eukaryotic Proteins.” Nat. Chem. Biol. 15, 213-216 (2019).\r
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Huang, R.; Han, M.; Meng, L.; Chen, X.* “ Capture and Identification of RNA-Binding Proteins By Using Click Chemistry-Assisted RNA-Interactome Capture (CARIC) Strategy” J. Vis. Exp. 140, e58580 (2018).\r
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Liang, L.; Tang, H; Deng, Z.; Liu, Y,; Chen, X.*; Wang, H.* “ Ag Nanoparticles Inhibit the Growth of the Bryophyte, Physcomitrella Patens.” Ecotoxicol. Environ. Saf. 164, 739-748 (2018).\r
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Qin, K.; Zhu, Y; Qin, W.; Gao, J.; Shao, X.; Wang, Y.; Zhou, W.*; Wang, C.*; Chen, X.* “ Quantitiative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker” ACS Chem. Biol. 13, 1983-1989 (2018).\r
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Bai, Q.; Dong L.; Hao, Y.; Chen, X.*; Shen, Q.* “ Metabolic Glycan Labeling-Assisted Discovery of Cell-Surface Markers for Primary Neural Stem and Progenitor Cells” Chem. Comm. 54, 5486-5489 (2018).\r
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Huang, R.; Han, M.; Meng, L; Chen, X.* “ Transcriptome-wide discovery of coding and noncoding RNA-binding proteins” Proc. Natl. Acad. Sci. USA 115, E3879-E3887 (2018).\r
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Wang, W.; Chen, X.* “ Antibiotics-Based Fluorescent Probes for Selective Labeling of Gram-Negative and Gram-Positive Bacteria in Living Microbiota” Sci. China Chem. 61, 792-796 (2018).\r
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Xu, Y.; Peng, L.; Wang, S.; Wang, A.; Ma, R.; Zhou, Y.; Yang, J.; Sun, D.; Lin, W.; Chen, X.; Zou, P.* “ Hybrid Indicators for Fast and Sensitive Voltage Imaging” Angew. Chem. Int. Ed. 57, 3949-3953 (2018).\r
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Sun, Y.; Hong, S.; Xie, R.; Huang, R.; Lei, R.; Cheng, B.; Sun, D.; Du, Y.; Nycholat, C.; Paulson, J.; Chen, X.* “ Mechanistic Investigation and Multiplexing of Liposome-Assisted Metabolic Glycan Labeling” J. Am. Chem. Soc. 140, 3592–3602 (2018).\r
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Qin, W.; Qin, K.; Fan, X.; Peng, L.; Hong, W.; Zhu, Y.; Lv, P.; Du, Y.; Huang, R.; Han, M.; Cheng, B.; Liu, Y.; Zhou, W.; Zhou, Y.; Wang, C.*; Chen, X.* “Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling” Angew. Chem. Int. Ed. 57,1817-1820 (2018).\r
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Du, Y.; Xie, R.; Sun, Y.; Fan, X.; Chen, X.* “Liposome-Assisted Metabolic Glycan Labeling with Cell and Tissue Selectivity” Methods Enzymol. 598, 321-353 (2018).