个人简历

2004-2008 BS in Chemical Biology, Tsinghua University\r
2008-2009 Research Assistant, Peking University\r
2009-2014 PhD in Chemistry, Columbia University\r
2015 Postdoc Researcher, Columbia University\r
2016-2018 Postdoc Researcher, Stanford University\r
2018- Assistant Professor, Peking University\r
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Dr. Zhixing Chen is a chemist with research experience spanning natural product synthesis, polymer mechano-chemistry, fluorescence and non-linear optical probes, bioconjugation, and live cell imaging. Zhixing believes in the enabling role of molecular technologies at the frontier of optical imaging, biotechnology, and life sciences. His current focus is to develop small and macro molecular tools for advanced imaging technologies. In the long term, Zhixing endeavors to unleash the synergy at the chemistry-biology-imaging interface in a collaborative manner, bringing new dimensions to the fields of molecular imaging and molecular medicine.

研究领域

"""""As an emerging yet interdisciplinary field

近期论文

Su, J. K.; Feist, J. D.; Yang, J.; Mercer, J. A. M.; Romaniuk, J. A. H.; Chen, Z.; Cegelski, L.; Burns, N. Z.; Xia, Y. Synthesis and Mechanochemical Activation of Ladderene–Norbornene Block Copolymers. J. Am. Chem. Soc. 2018, 140, 12388.\r
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Shi, L.; Zheng, C.; Shen, Y.; Chen, Z.; Silveira, E. S.; Zhang, L.; Wei, M.; Liu, C.; de Sena-Tomas, C.; Targoff, K.; Min, W. Optical imaging of metabolic dynamics in animals. Nature Communications 2018, 9, 2995.\r
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Qiao, Y.; Zhou, Z.; Chen, Z.; Du, S.; Cheng, Q.; Zhai, H.; Fritz, N. J.; Du, Q.; Yang, Y. Visualizing ion diffusion in battery systems by fluorescence microscopy: A case study on the dissolution of LiMn2O4. Nano Energy 2018, 45, 68.\r
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Chen, Z.; Mercer, J. A. M.; Zhu, X.; Romaniuk, J. A. H.; Pfattner, R.; Cegelski, L.; Martinez, T. J.; Burns, N. Z.; Xia, Y. Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene. Science 2017, 357, 475-479 [Front Cover].\r
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Wei, L.; Chen, Z.; Shi, L.; Long, R.; Anzalone, A. V.; Zhang, L.; Hu, F.; Yuste, R.; Cornish, V. W.; Min, W. Super-multiplex vibrational imaging. Nature 2017, 544, 465-470.\r
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Wei, L.; Hu, F.; Chen, Z.; Shen, Y.; Zhang, L.; Min, W., Live-Cell Bioorthogonal Chemical Imaging: Stimulated Raman Scattering Microscopy of Vibrational Probes. Acc. Chem. Res. 2016, 49, 1494-1502\r
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Anzalone, A. V; Chen, Z.; Cornish, V. W. Synthesis of Photoactivatable Azido-acyl Caged Oxazine Fluorophores for Live-cell Imaging. Chem. Commun. (Camb). 2016, 52, 9442-9445\r
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Freyer, J. L.; Brucks, S. D.; Gobieski, G. S.; Russell, S. T.; Yozwiak, C. E.; Sun, M.; Chen, Z.; Jiang, Y.; Bandar, J. S.; Stockwell, B. R.; Lambert, T. H.; Campos, L. M., Clickable Poly(ionic liquids): A Materials Platform for Transfection. Angew. Chem. Int. Ed. 2016, 55, 12382-12386\r
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Hu, F.; Chen, Z.; Zhang, L.; Shen, Y.; Wei, L.; Min, W. Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering. Angew. Chem. Intl. Ed. 2015, 54, 9821-9825\r
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Chen, Z.; Paley, D. W.; Wei, L.; Weisman, A. L.; Friesner, R. A.; Nuckolls, C.; Min, W. Multicolor Live-Cell Chemical Imaging by Isotopically Edited Alkyne Vibrational Palette. J. Am. Chem. Soc. 2014, 136, 8027–8033.\r
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Wei, L.; Hu, F.; Shen, Y.; Chen, Z.; Yu, Y.; Lin, C.-C.; Wang, M. C.; Min, W. Live-Cell Imaging of Alkyne-Tagged Small Biomolecules by Stimulated Raman Scattering. Nat. Methods 2014, 11, 410–412.\r
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Chen, Z.; Cornish, V. W.; Min, W. Chemical Tags: Inspiration for Advanced Imaging Techniques. Curr. Opin. Chem. Biol. 2013, 17, 637–643.\r
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Anzalone, A. V; Wang, T. Y.; Chen, Z.; Cornish, V. W. A Common Diaryl Ether Intermediate for the Gram-Scale Synthesis of Oxazine and Xanthene Fluorophores. Angew. Chem. Int. Ed. Engl. 2013, 52, 650–654.\r
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Xu, F.; Wei, L.; Chen, Z.; Min, W. Frustrated FRET for High-Contrast High-Resolution Two-Photon Imaging. Opt. Express 2013, 21, 14097–14108.\r
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Zhang, L.; Xu, F.; Chen, Z.; Zhu, X.; Min, W. Bioluminescence Assisted Switching and Fluorescence Imaging (BASFI). J. Phys. Chem. Lett. 2013, 4, 3897–3902.\r
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Chen, Z.; Jing, C.; Gallagher, S. S.; Sheetz, M. P.; Cornish, V. W. Second-Generation Covalent TMP-Tag for Live Cell Imaging. J. Am. Chem. Soc. 2012, 134, 13692–13699.\r
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Gatzogiannis, E.#; Chen, Z.#; Wei, L.; Wombacher, R.; Kao, Y.-T.; Yefremov, G.; Cornish, V. W.; Min, W. Mapping Protein-Specific Micro-Environments in Live Cells by Fluorescence Lifetime Imaging of a Hybrid Genetic-Chemical Molecular Rotor Tag. Chem. Commun. (Camb). 2012, 48, 8694–8696.\r
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Chen, Z.#; Wei, L.#; Zhu, X.#; Min, W. Extending the Fundamental Imaging-Depth Limit of Multi-Photon Microscopy by Imaging with Photo-Activatable Fluorophores. Opt. Express 2012, 20, 18525–18536.\r
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Wei, L.; Chen, Z.; Min, W. Stimulated Emission Reduced Fluorescence Microscopy: A Concept for Extending the Fundamental Depth Limit of Two-Photon Fluorescence Imaging. Biomed. Opt. Express 2012, 3, 1465–1475.\r
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Li, Y.; Chen, Z.-X.; Xiao, Q.; Ye, Q.-D.; Sun, T.-W.; Meng, F.-K.; Ren, W.-W.; You, L.; Xu, L.-M.; Wang, Y.-F.; et al. Diastereoselective Total Synthesis of (±)-Schindilactone A, Part 2: Construction of the Fully Functionalized CDEFGH Ring System. Chem. Asian J. 2012, 7, 2334–2340.\r
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Ren, W.-W.; Chen, Z.-X.; Xiao, Q.; Li, Y.; Sun, T.-W.; Zhang, Z.-Y.; Ye, Q.-D.; Meng, F.-K.; You, L.; Zhao, M.-Z.; et al. Diastereoselective Total Synthesis of (±)-Schindilactone A, Part 3: The Final Phase and Completion. Chem. Asian J. 2012, 7, 2341–2350.\r